Interoperability between electronic health records (EHR) and immunization information systems (IIS) may positively influence data quality, affecting timeliness, completeness, and accuracy of these data. However, the extent to which EHR/IIS interoperability may influence the day-to-day vaccination workflow and related recordkeeping tasks performed at medical practices is unclear. This study aimed to assess how EHR/IIS interoperability may influence the vaccination workflow at medical practices and to identify related impacts on clinical and administrative activities. We identified practices (family medicine, pediatrics, internal medicine, local health departments) from the Michigan Care Improvement Registry (MCIR), the statewide IIS in Michigan, representing each of the three HL7 interoperability levels (non-HL7, unidirectional, bidirectional). We conducted semi-structured interviews to assess how practices interact with the MCIR throughout the vaccination workflow. Transcripts were reviewed and coded to characterize practices' use of EHRs, MCIR, and other related technologies across the vaccination workflow. Practices completed Phase 1 (n = 45) and Phase 2 (n = 42) interviews, representing a range of medical specialties, geographic locations, and sizes. HL7 connectivity expanded among the participating practices; by the conclusion of the study, all practices had initiated at least unidirectional HL7 capability. Providers and staff relied heavily upon both their EHRs and MCIR throughout a wide range of vaccination-related activities. Most practices relied on MCIR as their primary source of vaccination history information, and nearly all practices also reported use of paper forms, documentation, and other summaries throughout the vaccination workflow. Practices employed both their EHRs and IIS throughout the entire vaccination workflow, although the use of each relied heavily on paper-based processes. While benefits of adopting EHR/IIS interoperability were reported by practices, this may require staff to learn and implement new workflow processes that can be time consuming and may introduce new challenges.
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