Objective. Тo evaluate the clinical effectiveness of sanatorium-resort treatment of patients who have suffered a new coronavirus infection COVID-19 with neuropsychological disorders. Material and methods. The study included 72 patients who had suffered a new coronavirus infection COVID-19 with neuropsychological disorders (17 men and 55 women) aged from 34 to 63 years, who were treated at the Federal State Budgetary Institution United Sanatorium Podmoskovye of the Administration of the President of the Russian Federation in the early stages after an illness — up to 3 months after a new coronavirus infection COVID-19). The patients were divided into 2 groups (main and control). Each group included 36 people (main group — 27 women and 9 men; control group — 28 women and 8 men). Patients of both groups received basic sanatorium-resort treatment, including: nutritional therapy (diet option with a high protein content), climatotherapy in the middle climate zone to prevent adaptation failure, health path (dosed walking), exercise therapy with elements of breathing exercises. Patients of the main group, in addition to the basic sanatorium-resort treatment, received transcranial electrical stimulation from the Transair-05 apparatus according to the standard method (current strength up to 1.5 mA or more, duration 30 minutes), for a course of 10–12 procedures. In a comparative aspect, the obtained data from patients of the main and control groups before and after sanatorium-resort treatment were studied: complaints, biochemical blood test indicators and the results of the MFI-20 asthenia rating scale. Results. The use of an expanded program of sanatorium-resort treatment with the inclusion of transcranial electrical stimulation in patients who have suffered a new coronavirus infection COVID-19 with neuropsychological disorders contributes to a significant reduction in the number and severity of clinical symptoms (complaints), improvement of the cognitive sphere, psycho-emotional and functional state, which is confirmed by the assessment scale data asthenia and MFI-20 on the subscales «General asthenia», «Physical asthenia» and «Mental asthenia». Conclusion. The inclusion of transcranial electrical stimulation in the sanatorium-resort treatment program in patients who have suffered a new coronavirus infection COVID-19 with neuropsychological disorders increases the effectiveness of rehabilitation treatment after an acute infectious disease, which justifies the feasibility of using TES in widespread clinical practice.