Purpose – The purpose of this paper is to elevate the accuracy when predicting the gross domestic product (GDP) on research and development (R&D) and to develop the grey delay Lotka-Volterra model. Design/methodology/approach – Considering the lag effects between input in R&D and output in GDP, this paper estimated the delay value via grey delay relation analysis. Taking the delay into original Lotka-Volterra model and combining with the thought of grey theory and grey transform, the authors proposed grey delay Lotka-Volterra model, estimated the parameter of model and gave the discrete time analytic expression. Findings – Collecting the actual data of R&D and GDP in Wuhan China from 1995 until 2008, this paper figure out that the delay between R&D and GDP was 2.625 year and found the dealy time would would gradually be reduced with the economy increasing. Practical implications – Constructing the grey delay Lotka-Volterra model via above data, this paper shown that the precision was satisfactory when fitting the data of R&D and GDP. Comparing the forecasts with the actual data of GDP in Wuhan from 2009 until 2012, the error was small. Social implications – The result shows that R&D and GDP would be both growing fast in future. Wuhan will become a city full of activity. Originality/value – Considering the lag between R&D and GDP, this work estimated the delay value via a grey delay relation analysis and constructed a novel grey delay Lotka-Volterra model.