Data In Dynamics Research Articles

The velocity extraction and feature analysis of glacier surface motion in the Gongar region based on multi-source remote sensing data

The movement of glaciers plays a crucial role in environmental and geological processes, significantly influencing the formation and dynamics of ice bodies. This study leverages feature tracking technology to analyze optical and Synthetic Aperture Radar (SAR) remote sensing imagery, specifically GF-1 optical images and GF-3, Sentinel-1 SAR images, captured during the 2020 to 2021 ablation season in Gongar. The aim was to quantify glacier surface velocities and to evaluate the comparative effectiveness of different remote sensing modalities in capturing these dynamics. Our findings indicate a strong consistency in the spatial distribution of glacier surface velocities derived from diverse remote sensing data sources, with high-precision optical imagery (GF-1) yielding the most accurate velocity measurements, followed by Sentinel-1 SAR data. Notably, large glaciers in Gongar exhibited rapid movements, with an average velocity of 0.16 m/d, primarily at elevations between 4,500 and 6,500 m. The fastest velocities were recorded at approximately 4,500 m elevation. Glaciers with inclines ranging from 10° to 60° displayed the highest velocities within the 20°–30° slope range. It was observed that glaciers on the southeast slope moved faster, exhibiting the highest average surface velocity, in contrast to those on the west slope, which moved more slowly. The surface velocity of the ice tongue region of Krayaylak Glacier that the largest glacier in Pamir, was observed to be lower than 0.6 m/d, indicating a slow movement speed. The study also reveals that the effectiveness of different remote sensing data in detecting glacier velocity in Gongar, with high-resolution data more accurately capturing surface velocities in melting areas or those with slower movement. This study underscores the importance of multi-source remote sensing data in understanding glacier dynamics and contributes valuable insights into the mechanisms driving glacier movements.

Registry of patients with autoimmune liver diseases in St. Petersburg: clinical and epidemiological data

BACKGROUND: The problem of autoimmune liver diseases, which include autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis and their overlap syndromes is an urgent problem of modern medicine. This is associated with an increase in the incidence and prevalence of these nosologies in different regions of the world. Absence of an established etiological factor, prolonged asymptomatic or low-symptomatic course, lack of pathognomonic clinical picture, imperfect diagnostic criteria, insufficient awareness of physicians lead to late diagnosis of autoimmune liver diseases and, accordingly, untimely initiation of treatment, which often reduces its effectiveness, affecting the further prognosis and survival rate for this group of patients. Patients with autoimmune liver diseases require long-term, often lifelong therapy and dispensary observation. Epidemiological registries along with autoimmune liver diseases registries, including various nosologies of autoimmune liver diseases, form an important database on the incidence, clinical features, development and course of the disease, variants of therapy and response to therapy, presence of extrahepatic manifestations as well as allow analysis of all data in dynamics. AIM: To analize data on various nosologies of autoimmune liver diseases, demographics, clinical symptoms, timing of the first symptoms, timing of diagnosis, and the nature of extrahepatic manifestations. MATERIALS AND METHODS: This article presents data from the autoimmune liver diseases Register of the North-West Hepatology Centre (North-West Autoimmune Liver Diseases Register) of the North-Western State Medical University named after I.I. Mechnikov. RESULTS: The study obtained data on the nosological structure, demographic characteristics, timing of diagnosis verification, clinical symptoms and extrahepatic manifestations of autoimmune liver diseases. CONCLUSIONS: Establishing registers of autoimmune liver diseases, providing information about patients with these diseases, will help to assess the effectiveness of examination and treatment methods, factors affecting the course and prognosis of the disease. Analysis of the data obtained will help to develop screening programs, diagnostic algorithms and differential diagnostics of autoimmune liver diseases, which, in turn, will facilitate the diagnostic process, shorten the time of diagnosis, make it possible to start therapy earlier and, consequently, improve the prognosis and survival rate for this group of patients.

Образ школы сегодня и завтра в контексте системы ценностей российских школьников

The image of the modern and future school in perception of high school students is examined in the context of understanding the system of their values and life views. Empirically the paper is based on the results of the field research undertaken by the author in September-October 2021 among the 9–11 grade students of St. Petersburg schools, followed by further investigation among the same target audience in January-February 2023. New questioning of the students was accompanied by the questioning of teachers, which allows us now not only to analyze the data in dynamics, but also to compare the views of students and teachers. Theoretical background of the research is based on the current sociological and psychological academic discussion about the concepts of happiness and meaningful life. We argue, that during the recent year and a half the image of modern and future school has significantly changed and this change bears the value-oriented character. First, the move from the values of life stability and comfort towards the values of personal and professional growth and achievements has been identified, i.e. from the consumer values to the values of development. Second, high school students demonstrate almost entire indifference towards the values of common good. And, third, the teachers’ perception of the teenagers’ values is significantly different from the reality in two important aspects: firstly, according to the teachers the students are much more oriented on consumer values, than it takes place in fact. And secondly, in the teachers’ perception students prioritize successful learning of curriculum disciplines much less than they actually do. According to teachers’ opinion friendship and communication are much more important to students than studies as such. This in fact may mean the attribution to the students the system of values, spread among the teachers, which causes major difficulties in identifying the optimal combination of teaching and upbringing.

A semi-supervised framework for computational fluid dynamics prediction

Data-driven deep learning approach heavily relies on the diversity and quantity of data. Acquiring data in the computational fluid dynamics (CFD) domain is a time and computationally intensive process. This paper proposes a semi-supervised learning method called discriminative regression fitters (DRF) for aerodynamic prediction of airfoils. DRF utilizes neural networks’ memory property to dynamically divide pseudo-labeled data into easy and difficult subsets using a model of Gaussian distribution. The method classifies unlabeled data based on loss and updates the pseudo-labeled data, improving the model’s generalization capability. Experiments on airfoil regression task datasets show that DRF achieves similar or better prediction accuracy than fully supervised approaches. It reduces data acquisition time by 70%. Ablation studies and qualitative results verify the effectiveness of DRF. The surrogate model obtained from DRF is extended to airfoil optimization, demonstrating its practicality. DRF provides a promising direction for improving the regression task while reducing the reliance on large amounts of CFD data.

Computational Fluid Dynamics and Its Potential Applications for the ENT Clinician.

This article is an examination of computational fluid dynamics in the field of otolaryngology, specifically rhinology. The historical development and subsequent application of computational fluid dynamics continues to enhance our understanding of various sinonasal conditions and surgical planning in the field today. This article aims to provide a description of computational fluid dynamics, the methods for its application, and the clinical relevance of its results. Consideration of recent research and data in computational fluid dynamics demonstrates its use in nonhistological disease pathology exploration, accompanied by a large potential for surgical guidance applications. Additionally, this article defines in lay terms the variables analyzed in the computational fluid dynamic process, including velocity, wall shear stress, area, resistance, and heat flux.

Predictors of an unfavorable outcome in patients with severe pneumonia against the background of COVID-19 infection

Objective. To determine the predictors of an unfavorable outcome in patients with severe pneumonia against the background of COVID-19 infection.Materials and methods. A retrospective analysis of the case histories of deceased patients (control group, n = 40) for January 2021 (a continuous sample — 15.01.21–31.01.21) and surviving patients for the same period (n = 40) with a confirmed PCR diagnosis of coronavirus infection, who were on inpatient treatment at the state healthcare institution “Gomel City Clinical Hospital No. 3” (SHI “GCCH №3”) in Gomel. The Ethical Committee of SHI “GCCH №3” found no violations contradicting ethics and morality in conducting the study. Treatment of patients, assessment of the severity of the condition were carried out according to modern protocols for the diagnosis and treatment of COVID-19 infection, approved by the Ministry of Health of the Republic of Belarus (No. 1195 of 11.11.2020). The group of surviving patients was represented by 11 men and 29 women versus 24 men and 16 women in the control group (p < 0.05).According to computed tomography of chest organs (CT CO), all 80 patients had signs of bilateral viral pneumonia characteristic of COVID-19. When processing and describing CT data, a semi-quantitative scale was used to estimate the volume of infiltration and consolidation zones of the lungs, recommended by temporary protocols. The total volume of lung damage in COVID-19 infection (“frosted glasses”, “cobblestone pavement”, “consolidation sites”) was > 55% in both groups, p > 0.05. CT CO was performed on Somatom Emotion 6 (Siemens) with a spiral type of scanning.Patients of both groups were comparable in age, concomitant comorbid pathology: coronary heart disease (CHD), arterial hypertension (AH), diabetes mellitus (DM), etc., however, they had differences in gender (the proportion of males prevailed in the group of deceased). A feature of the study was a solid sample among deceased patients. Taking into account the group differences by gender, in this study, an additional comparison of the results by gender was carried out. Results. The course of COVID-19 infection at the stationary stage is characterized by large-scale negative clinical dynamics, fever, “explosion” of acute phase indicators, thrombosis, distress syndrome with a drop in saturation and unfavorable outcomes. The indicators obtained using the NEWS-2, SHOCK-COVID scales (scales for predicting the severity of the clinical course of coronavirus infection) in severe patients, although they indicate a worsening of the patient’s clinical condition, but rather late, when the “cytokine storm”, powerful inflammation, thrombosis, significant damage to lung tissue already dominate among clinical syndromes, the decrease in saturation and the effectiveness of drug therapy is significantly limited.Conclusion. According to the results of the study, it is recommended to divide patients into groups of moderate and high risk of adverse outcome based on clinical, instrumental, laboratory data in dynamics. In patients with moderate risk, protocol therapy in most cases is sufficient to stabilize the general condition. In patients with an unfavorable outcome, this therapy does not restrain the growth of lung tissue damage with negative clinical, laboratory dynamics, which requires additional decisions, changes in the doses of drug therapy to prevent fatal outcomes.

ANALYSIS OF THE CURRENT STATE AND DIAGNOSIS OF KEY PROBLEMS OF PUBLIC ADMINISTRATION IN THE HEALTHCARE SECTOR IN THE REPUBLIC OF KAZAKHSTAN

Healthcare is one of the most important areas of activity of any state. One of the goals of sustainable development, the United Nations (UN) proclaims “Ensuring a healthy lifestyle and promoting well-being for all at any age.” The efforts of all countries of the world are directed towards the realization of this goal, since the health of the nation and the high standard of living of the country’s population are important components of the sustainable development of each country. In this regard, the article emphasizes that healthcare is one of the most important areas of activity of any state, and effective public administration in this area is critical, so the goal was to develop proposals and recommendations to ensure high-quality and affordable medical care for all segments of the population. For this purpose, various research meth-ods were used, such as the method of scientific abstraction, the method of induction and deduction, literature analysis and statistical analysis of modern data in dynamics over the past 5 years, the method of generalization and comparative analysis, which were used to identify problems and develop recom-mendations to improve the availability and quality of medical care, ensure public health and improve the quality of life of the population. In light of the challenges Kazakhstan has faced in public health management, including pandemics, demographic changes and technological innovations, we have pro-posed: introducing an automated data processing system in all regions of the country, improving the system of monitoring and analyzing health management, optimizing the financing system, developing a mechanism for monitoring and overseeing the provision of high-quality and affordable medical care to all segments of the population.

СТРАТЕГІЯ ОРГАНІЗАЦІЙНОЇ СТАЛОСТІ РЕГІОНАЛЬНО-ЗНАЧИМОЇ КЛАСТЕРНОЇ ЛІКАРНІ

The article considers the main results of the last stage of the reform of the public health system, its structural restructuring and the creation of hospital districts in Ukraine, considers in more detail the Odessa region and its features. The normative legal acts on which the reform system is based are considered, as well as the results obtained in the Odessa region as of 20.12.2023. The structure of the Odessa hospital district and the features of its construction are investigated. As of 20.12.2023 in Ukraine, 19 regions have formed capable hospital networks, which include 562 institutions, of which 123 are super-clustered hospitals, 157 cluster HCFs and 282 general health care institutions. In the Odessa region, the capable network of the Odessa hospital district included: 7 cluster districts, 5 supercluster hospitals, 13 cluster hospitals, 20 general hospitals. In addition to primary care and emergency medical care facilities, 38 specialized medical care facilities were included. Methodological or regulatory support for the development of such documents neither the CMU, nor the Ministry of Health or health departments provide. Therefore, we proposed a reference model for developing a strategic development plan that can be used for a cluster or general hospital. The reference model for formation of the strategy of organizational development and constancy is offered. In which the structural process of describing the main elements of the strategy for the development of HCV is provided, an approximate example of performing a SWOT analysis for a cluster hospital is given. The passport of description of business processes and indicator, which contains information about business directions, units of measurement, method of calculation, data sources, multiplicity of data collection and methods of verification, criteria of evaluation of data in dynamics, responsible persons and owners of business processes, and its fragment is given. It also considers what should be included in operational annual plans to ensure the necessary effectiveness and viability of the strategy. There are no strict requirements for a strategic plan for the development of a health care institution. This will allow institutions to adapt plans to their real needs, develop and adjust documents that will help develop according to an understandable scenario and measure results.

The impact of linguistic and cultural identity development on the growth of the economy of the Republic of Kazakhstan

Relevance. In view of globalisation and the territorial disputes in the Eurasian region, which have escalated to warfare, the issue of national identity has become particularly relevant.Purpose. The research aims to determine the dynamics of the cultural identity of the citizens of the Republic of Kazakhstan (RK), identify the key directions in the further development of the traditions of the Kazakh people and describe the impact of these processes on the growth of the country�s economy.Methodology. Methods of statistical analysis and forecasting were applied, a list of key indicators was compiled and a trend line was formed. Regression analysis was also performed to better understand the relationship between the indicators, and an internet questionnaire survey of the citizens of the Republic of Kazakhstan was compiled to determine the subjective perception of the nation�s iconic symbols and to find out the dynamics of actual household incomes.Results. As a result, data were obtained on the total number of RK residents, those who identify themselves as Kazakhs, and those who consider Kazakh as their native language. These data in dynamics were compared with the indicators of gross domestic product, which demonstrated a clear direct correlation between these phenomena, additionally confirmed by regression statistics. In addition, the relationship between the growth of cultural identity and the increase in television content in the Kazakh language was analysed.Conclusions. The practical significance of the work lies in obtaining a confirmed way of achieving economic growth through the influence of national television, as well as the presence of representative feedback from society on such key programmes as the development of national identity, the creation of iconic landmarks and national parks, and support for Qazaq repatriates to their historical homeland.

Optimizing measurement schemes to improve indoor airflow and temperature CFD–EnKF joint simulation

An ensemble Kalman filter (EnKF) effectively rectifies simulation inaccuracies arising from uncertain flow field boundary conditions. In this methodology, measurement data plays a pivotal and indispensable role. This study investigated the requirements for observation data in joint EnKF and computational fluid dynamics (CFD) simulation models to correct errors. It established guiding principles for measurement schemes and validated them using numerical experiments on the airflow and temperature fields in a small chamber. The optimized scheme significantly reduced simulation errors, enhancing assimilation accuracy. In addition, the influence of measurement noise was considered, revealing a positive correlation between assimilation and measurement errors, thus highlighting the significance of high-precision instruments. Additionally, this study confirmed that the optimal number of measurement points corresponds to the number of uncertain boundary condition variables. Fewer measurement points hinder accurate estimation, whereas increasing their number does not significantly improve the data assimilation accuracy, regardless of measurement noise. Overall, this study provides guidelines for implementing EnKF data assimilation to ensure reliable and precise results.

КВЧ-ТЕРАПИЯ И ГИРУДОТЕРАПИЯ В КОМПЛЕКСНОМ ЛЕЧЕНИИ ХРОНИЧЕСКИХ ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЙ ОРГАНОВ МАЛОГО ТАЗА ЖЕНЩИН

The aim of the study was to evaluate the effectiveness of the combined use of EHF-puncture and hirudotherapy (HT) in chronic pelvic inflammatory diseases in women and to substantiate the expediency of including a combination of these non-drug therapeutic factors in the combination treatment of pelvic inflammatory diseases (PID). Under observation there were 128 women aged 20 to 45 years (31.8 ± 0.41 years) with chronic adnexitis, chronic endometritis and both diseases at the stage of complete and incomplete remission. In 70.3% of patients, concomitant hormone-dependent diseases were recorded: fibromyoma of the uterine body, endometriosis and their combination. All patients were randomized into 2 groups: the main group (74 subjects) and the comparison group (54 subjects). The multimodality treatment of patients of the main group included EHF-therapy through the action upon biologically active points (BAP) and HT. The effectiveness of the treatment was assessed by the results of the analysis of the visual analogue scale of pain, bimanual and ultrasound examination data in dynamics. The combined use of EHF-puncture and hirudotherapy ensured the achievement of an analgesic effect in 82.9% of cases, an anti-inflammatory effect in 51.8% of cases, a resolving effect in 93.7% of cases, and contributed to the normalization of hemodynamics of the pelvic organs in 68.8% of cases. Under the influence of EHF-puncture and HT, the manifestations of endometriosis and fibromyoma of the uterine body decreased. The results of the study prove the clinical effectiveness of the combined use of EHF-puncture and hirudotherapy in the treatment of PID in women, including those with concomitant hormone-dependent gynecological diseases.

THE USE OF STATINS FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND TYPE 2 DIABETES

Relevancy. The combination of chronic obstructive pulmonary disease and type 2 diabetes is studied insufficiently. The incomplete treatment regimen hinders the solution to this problem by including statins in the complex treatment of patients with chronic obstructive pulmonary disease combined with type 2 diabetes mellitus.
 Objective: to evaluate the effectiveness of including statins in the complex treatment of patients with chronic obstructive pulmonary disease secondary to type 2 diabetes mellitus.
 Materials and methods. Examination of patients with chronic obstructive pulmonary disease (COPD), including 64 patients with concomitant type 2 diabetes, was conducted on the basis of the pulmonology department of the Chernivtsi Regional Clinical Hospital in 2016-2020. Patients were divided into two groups – the main and the control. Patients with COPD with concomitant type 2 diabetes in the main group (49 patients) were prescribed atorvastatin at a dose of 20-40 mg once a day. The control group (15 COPD patients with concomitant type 2 diabetes) received essential treatment without atorvastatin. Patients received basic therapy depending on the group of patients (A, B, C and D) and the prevalence of shortness of breath or the frequency of exacerbations, long-acting bronchodilators (long-acting β2-agonists and/or long-acting anticholinergic drugs). A separate group of patients received a combination of a long-acting β2-agonist with an inhaled glucocorticosteroid. Some patients were prescribed roflumilast and antibactereal drugs from the group of macrolides (azithromycin or erythromycin). In the presence of sputum, patients were prescribed mucolytic drugs (Lazolvan, ACC, carbocisteine, erdosteine). In case of exacerbation, patients received a short course glucocorticosteroids parenterally, antibacterial drugs (for infectious exacerbation), nebulizer therapy. The effectiveness of therapy was evaluated after six months of treatment using the following diagnostic methods: clinical data (dyspnea, cough, sputum production - according to the BCSS scale; and shortness of breath, cough, sputum production and its color - according to the Paggiaro scale), the number of hospitalizations per year, the number emergency medical calls. Mathematical processing of the obtained data was carried out using programs BioStat 2009 Professional, version 5.8.4.3 (AnalystSoft Inc.), SPSS (Statistical Package for Social Science Statistics) 16.0, Statistisa 10.0 StatSoft Inc., Microsoft Excel 2010. Before testing statistical hypotheses were determined coefficients of asymmetry and kurtosis using the Hahn-Shapiro-Wilkie test to analyze the normality of the distribution of values ​​in randomized samples.
 Results. When analyzing clinical data in treatment dynamics with atorvastatin, it was found that according to the BCSS, shortness of breath in patients of the main group significantly decreased. Cough in COPD patients with concomitant type 2 diabetes treated with atorvastatin decreased by 25.3% at the end of treatment. A decrease in sputum production was observed in two groups of patients, and the changes were significant. Reduction of the frequency of exacerbations per year, the number of emergency calls, and the number of hospitalizations per year in the dynamics of atorvastatin treatment were also observed in COPD patients with concomitant type 2 diabetes.
 Conclusion. the use of atorvastatin in the complex treatment of COPD patients with concomitant type 2 diabetes resulted in a decrease in the frequency of exacerbations per year, the number of emergency calls, and the number of hospital admissions per year.

The place of laser fluorescence spectroscopy, doppler flowmetry and ultrasound in the diagnosis and assessment of treatment efficacy for plaque scleroderma

According to modern ideas, a reasonable choice of an effective method of treating plaque scleroderma is based on the diagnosis of the pathological process prevailing in the tissues (inflammation-sclerosis). Therefore, an urgent problem of a personalized approach to dermatosis therapy is the possibility of an objective assessment of the prevailing process using non-invasive diagnostic methods. The article presents a clinical case of widespread plaque scleroderma in a 66-year-old patient, demonstrating the possibility of using laser fluorescence spectroscopy and laser Doppler flowmetry to determine the degree of activity of the focus and determine the leading pathological process.
 We selected three pathological skin foci localized in the abdomen and characterizing three clinical stages of the disease (inflammation, induration, sclerosis). The analysis of fluorescence and laser Doppler flowmetry data showed that in areas clinically defined as inflammation, there is an increase in the average values of the indices of tissue content of porphyrins, lipofuscin and microcirculation index compared with intact skin, while the intensity of collagen fluorescence does not differ significantly. In the induration zone, along with an increase in the fluorescence indices of lipofuscin and porphyrins, there is an increase in the average values of collagen fluorescence indices at effective registration waves. The data obtained by us indicate an active inflammatory process in these foci and the process of fibrosis in the induration zone. In the sclerosis zone, there is an increase in the average values of collagen fluorescence indices compared with intact skin, and the fluorescence of optical markers of inflammation (lipofuscin and porphyrins) do not differ significantly in comparison with the control intact skin. When analyzing the fluorescence spectra and laser Doppler flowmetry data after treatment, we found that in the zones of induration and inflammation, the average values of the fluorescence indices of porphyrins, lipofuscin, collagen and microcirculation index are reduced relative to the initial values (before treatment), but remain higher in comparison with intact skin. The data obtained may indicate that active inflammation in these foci persists at the time of the study. In the study of the focus of sclerosis, the obtained autofluorescence and microcirculation data in dynamics do not differ significantly from the initial values. The data for laser Doppler flowmetry and laser fluorescence spectroscopy are consistent with ultrasound examination of the skin.
 In our study, the potential possibility of using laser fluorescence spectroscopy and laser Doppler flowmetry methods to establish the degree of activity of the focus, determine the leading pathological process, as well as to evaluate the effectiveness of therapy was demonstrated for the first time.

Clinical case of long-term persistence of SARS-CoV-2 in infant with congenital acute myeloid leukemia

According to the available data, children are less susceptible for developing a severe course of COVID-19 and commonly have mild or asymptomatic course of infection. It is reported about an increased risk of having more severe course in infants, at the same time, according to the literature data, the course in children receiving antineoplastic and immunosuppressive therapy is milder in comparison with other concomitant pathologies. This article presents the unique clinical case and the literature review of combined COVID-19-pneumonia and extremely rare congenital myeloid leukemia in the infant with the description of long-term infection persistence, changes in clinical data in dynamics, bone marrow test results and the experience of using donor plasma with antibodies to SARS-CoV-2.

Methodological challenges in the analysis of agrifood systems: a mixed-method approach

Objective: The main goal of this paper consists in analyzing the potential of mixed methods used in the study of two agrifood systems: Iberian ham (Spain) and chorizo from the Toluca Valley (Mexico). Research limitations: Opposing cultural contexts that allowed different strategies to be used which sought not only to collect information from the diverse actors in each system but also face the methodological challenges that currently prevail. These challenges are linked to the diversity of the actors themselves and to the use of new technologies for data collection. Methodological design: To solve these methodological shortcomings, mixed methods have been implemented with the support of technological innovations. Results: Results allow us to verify that the employment of mixed methods is an excellent means for leveraging resources effectively and efficiently. In Spain, employing a self-administered survey enabled rural manufacturers to control the timing of their response. Regarding consumer results, these prove that collecting data via smartphone is highly recommended. In the case of Mexico, starting the research quatitatively allowed the building of trust, a factor which is critical given the levels of violence in Mexican society that generate mistrust and, ultimately, lead to a refusal to participate in academic research. Findings: The main contribution of this article is that, based on real and complex cases, it provides evidence of the potential and strategies to be followed for analyzing agrifood systems in a cross-cultural research. Mixed methods emerge as an excellent means for collecting data in global dynamics.

Quantitative characteristics of radiation-induced lung damage in oncological patients during radiotherapy based on RCT data

Objective. Comparison of the magnitude of the change in the density of lung tissue and the volume of these changes after radiation therapy over time based on the data obtained using the new method of quantitative analysis developed by us and with the usual visual assessment of the CT data.Materials and methods. We used the data of dynamic observation of 90 patients who underwent RT for the tumors of thoracic localization during the period from 2014 to 2021 at the Federal Institution “Russian Scientific Center of Roentgenoradiology”. These patients had CT examinations performed before and after RT. Control CT studies were performed 1–237 days after RT (mean control interval 96 ± 64.3 days). A total of 238 CT studies of these patients were analyzed, with an average number of RCT studies per patient of 2.6. Among the selected patients, there were 36 (40%) men and 54 (60%) women aged 23 to 86 years (the average age was 51.9 ± 15.6 years).Results. Radiation damage in the lungs using the method of quantitative analysis of CT data is detected starting from the value of ΔHU = 20 and volume from 3.2% for the early period (15–35 days) after the end of treatment. Starting from 15–25 to 50 days after the end of RT, quantitative analysis reveals primary changes in the lung tissue, incl. and undetectable visually (from 20 to 80 HU), and to suggest further dynamics of these changes depending on the characteristics of the performed RT. From 50 to 80 days – reveals the real volume of radiation pulmonitis by taking into account the changes invisible during visual analysis in the lung tissue irradiated at a dose of 20 Gy to 30 Gy. From 80 to 120 days – allows you to assess the presence and dynamics of changes in the lung tissue with the threshold radiation dose in the lung tissue 30–35 Gy. From 120 onwards, quantitative analysis of CT data, as well as visual assessment, reveals damage in areas of the lungs with the dose of more than 30–35 Gy, which is caused by post-radiation pneumofibrosis. On the basis of the obtained quantitative data on radiation lung damage, the mathematical regularities of the development of this process were calculated, taking into account the time and dose factors.Conclusions. Quantitative assessment of changes in lung density according to CT data in dynamics, carried out using the technique developed by us, is a radiomic indicator of their radiation damage during therapeutic irradiation in cancer patients, which, in combination with the presented mathematical model, can be used for diagnostic purposes to quantify the severity and predicting the dynamics of radiation damage to the lungs in general, as well as identifying individual radiosensitivity.The results obtained can be presented not only in the form of graphs, but also in the form of color maps with preservation of anatomical landmarks, which is convenient for use in clinical practice to support medical decision-making on patient management.

Epileptic encephalopathy caused by 1p36 deletion: literature review and case series

1p36 deletion syndrome (OMIM: 607872) is an autosomal dominant disease caused by a terminal deletion of the short arm of chromosome 1, characterized by specific craniofacial dysmorphism, delayed speech development and epilepsy. The severity of epilepsy is related to the size of the mutation.Objective: to study the clinical and electroencephalographic picture of the disease.We have analyzed 3 cases (male patients from 2 to 6 years old), including anamnesis of life and disease, electroencephalography data in dynamics and genetic analysis data.All three patients are united by a combination of epilepsy, mental retardation and cerebral palsy-like movement disorders. The epilepsy manifestations varied from severe with absolutely pharmacoresistant epileptic spasms (cases 1 and 2) to mild course with febrile seizures only (case 3). This is probably due to the presence of a shorter mutation in patient 3. Cases 1 and 2 had epileptic encephalopathy, epilepsy with continuing epileptiform discharges on the EEG and a gross delay in speech and mental development. These patients could not speak and not understand the speech addressed, do not follow instructions. Patient 3’ self-care and play activities are developed by age, speech understanding is fully formed, but there is a complete absence of expressive speech.1p36 deletion syndrome is a developmental and epileptic encephalopathy.

Reconstruction of sparse recurrent connectivity and inputs from the nonlinear dynamics of neuronal networks.

Reconstructing the recurrent structural connectivity of neuronal networks is a challenge crucial to address in characterizing neuronal computations. While directly measuring the detailed connectivity structure is generally prohibitive for large networks, we develop a novel framework for reverse-engineering large-scale recurrent network connectivity matrices from neuronal dynamics by utilizing the widespread sparsity of neuronal connections. We derive a linear input-output mapping that underlies the irregular dynamics of a model network composed of both excitatory and inhibitory integrate-and-fire neurons with pulse coupling, thereby relating network inputs to evoked neuronal activity. Using this embedded mapping and experimentally feasible measurements of the firing rate as well as voltage dynamics in response to a relatively small ensemble of random input stimuli, we efficiently reconstruct the recurrent network connectivity via compressive sensing techniques. Through analogous analysis, we then recover high dimensional natural stimuli from evoked neuronal network dynamics over a short time horizon. This work provides a generalizable methodology for rapidly recovering sparse neuronal network data and underlines the natural role of sparsity in facilitating the efficient encoding of network data in neuronal dynamics.

Development of psychology of research behavior of the individual

Introduction. Today, many values have lost their inherent polarity of good and evil, moral consciousness has turned out to be the leading determinant, the effectiveness of which is manifested precisely in psychology, consciousness and behavior of the individual. Purpose setting. The starting point of our study is the information theory of emotions by P. V. Simonov. But if P. V. Simonov studied in detail the emotional effect of the information situation, then for us it is more important and interesting to solve the inverse problem – the emotional stimulation of the functions of the intellect, directly forming consciousness, which became the subject and result of our study, the specificity of which was the convergence of cognition and experience, cognitive, emotional and behavioral. Methodology of the study. To analyze the research behavior of adolescent students and undergraduates general scientific research methods were used (i.e. experiment, modeling method, a program for finding patterns for legal, moral, social, terminal and instrumental values – PolyAnalyst, etc.), as well as diagnostic methods and specially organized directed training, correlation and factor analyzes of the entire volume of obtained data in dynamics. Results. A new experimental direction in the development of the psychology of exploratory behavior, the study of patterns and mechanisms of emotional reactions of a person, the influence of actualized emotions on the effectiveness of the moral development of a person is presented. A longitudinal study of the values of the personality structure was carried out in terms of its dynamics, stability, connection with meaningful life orientations and interrelations with the general personal and specific emotional properties of the respondents. Conclusion. Personality is considered not only as a product of formation and learning by adults, but also as an autonomous sociocultural reality, which allows us to get out of the old model of "becoming" and outline a new range of problems and issues in the theory and practice of the moral development of the students. In this article we have taken a systematic study of the specificity and relationship of the emotional-sensory, intellectual and cognitive, behavioral spheres, their relationship with individual and personal qualities, which is its value and scientific novelty. The unity of the position of all social factors in the process of emotional and moral development of the individual and the humane focus of the entire spectrum of influence, in the center of which is the individuality as an active creative principle, are necessary.

Boundary Layer via Multifractal Mass Conductivity through Remote Sensing Data in Atmospheric Dynamics

In this manuscript, multifractal theories of motion based on scale relativity theory are considered in the description of atmospheric dynamics. It is shown that these theories have the potential to highlight nondimensional mass conduction laws that describe the propagation of atmospheric entities. Then, using special operational procedures and harmonic mappings, these equations can be rewritten and simplified for their plotting and analysis to be performed. The inhomogeneity of these conduction phenomena is analyzed, and it is found that it can fluctuate and increase at certain fractal dimensions, leading to the conclusion that certain atmospheric structures and phenomena of either atmospheric transmission or stability can be explained by atmospheric fractal dimension inversions. Finally, this hypothesis is verified using ceilometer data throughout the atmospheric profiles.