Dashed Line Research Articles

Identifying Key Descriptors for the Single-Atom Catalyzed CO Oxidation

Identifying Key Descriptors for the Single-Atom Catalyzed CO Oxidation

Induced Seismicity and Acute Development of Anxiety and Stress-Related Mental Disorders: Findings from the 2017 Pohang Earthquake.

Induced Seismicity and Acute Development of Anxiety and Stress-Related Mental Disorders: Findings from the 2017 Pohang Earthquake.

Deep-learning-based detection of missing road lane markings using YOLOv5 algorithm

Road lane markings are critical for ensuring road user safety. To improve their safety, there are even different types of road lane markings, such as single solid lines, double solid lines, dashed single line etc. Their colors generally are white and yellow. This road lane markings mainly used to provide guidance and information for road user to comply with the rule of the road. Unfortunately, these markings get worn out with time and may even disappear. In order to prevent this from happening, regular inspection and maintenance need to be conducted. Manual inspection is tedious, slow, and prone to human errors. With the recent technological advancement, especially in machine vision and artificial intelligence, automated or semi-automated missing road lane marking detection systems can potentially be developed. In this work, preliminary study of the implementation of one of the latest deep learning algorithms, i.e. YOLOv5, has been carried out in the detection and classification of missing road lane markings. This paper shows the preliminary results which look promising as the mean Average Precision (mAP@0.5) reaches 0.995.

C–H⋯S Hydrogen Bond Assisted Supramolecular Encapsulation of Fullerenes with Nanobelts

C–H⋯S Hydrogen Bond Assisted Supramolecular Encapsulation of Fullerenes with Nanobelts

Subjective identification and ablation of drivers in persistent atrial fibrillation (CHAOS-AF study): results of the first 50 patients

Abstract Funding Acknowledgements Type of funding sources: None. Background Ablation of drivers in persistent atrial fibrillation (AF) has shown controversial results [1-5]. Purpose To test the efficacy of a tailored approach for persistent AF ablation which includes pulmonary vein isolation (PVI) plus ‘subjective’ identification and ablation of drivers. Methods From May 2017, selected patients with persistent AF and ongoing AF at the beginning of the ablation procedure were included. Conventional high-density mapping catheters were used. Drivers were subjectively identified as: a) fractionated continuous (or quasi-continuous) electrograms on 1-2 adjacent bipoles, without dedicated software (Figure, A, dashed line; PR = PentaRay NAV); and b) sites with spatiotemporal dispersion (i.e. all the cycle length comprised within the mapping catheter) plus non-continuous fractionation on single bipoles (Figure, B, arrows; in panels A and B: paper speed 200 mm/s; ORB = 24-pole ORBITER Woven catheter, blue bipoles around tricuspid annulus and green bipoles into the coronary sinus). Ablation included PVI + focal or linear ablation targeting sites with drivers. Ablation success was defined as conversion to sinus rhythm or atrial flutter during ablation. Follow-up included visits with 24h Holter ECG at 3-6-12 months. The primary endpoint was one-year survival free from atrial arrhythmias lasting >30 seconds. We present the results of the first 50 patients included, comparing them with all consecutive patients with persistent AF treated with a PVI-only strategy. Results 173 Patients received ablation: 50 with the tailored approach (61,2±9,6 years; 24% females) and 123 with only PVI (62,5±9,6 years; 25% females; 89% cryoablation). Basal characteristics were similar (Table), but more patients with long-standing persistent AF were ablated witth the tailored-approach group. In the tailored-approach group, 21 patients (42%) presented 40 detectable sites with continuous fractionated electrograms, 38 on the left atrium and 2 on the right atrium, which was only mapped if ablation of drivers in the left atrium was not successful; 18 (45%) were located within the pulmonary vein antra. 41 patients (82%) showed 143 sites with spatiotemporal dispersion (4 [3 – 4] per patient). Ablation success was achieved in 21 patients (42%; conversion to sinus rhythm, n=7; conversion to atrial flutter, n=14) in the tailored-approach group and 1 patient (0,8%, sinus rhythm) in the PVI-only group. Excluding a 3-month blanking period, the tailored approach, compared to only PVI, improved one-year freedom from atrial arrhythmias (70% Vs 52%, p=0,032) (Figure, C), at the cost of a longer median procedural time (244 [187–275] Vs 108 [81–143] min, p<0,001) and fluoroscopy time (41 [28–65] Vs 33 [21–45] min, p<0,001). Conclusion Subjective identification and ablation of drivers, added to PVI, improved one-year survival free from atrial arrhythmias.

A Smart Molecule Showing Spin Crossover Responsive Aggregation-Induced Emission

A Smart Molecule Showing Spin Crossover Responsive Aggregation-Induced Emission

Insights into the intracardiac electrogram from analytical and numerical modelling

Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): FWO-Flanders, KU Leuven internal starting grant Introduction and Purpose Cardiac electrograms (EGMs) are one of the most important recordings obtained during electroanatomical voltage mapping and lie at the basis for planning most clinical electrophysiological interventions. Despite its widespread use, the relation of EGM shape and amplitude to the underlying excitation patterns and properties of cardiac tissue is not completely understood. Recent clinical studies [1] have provided important new guidelines on the relation between EGM amplitudes and the thickness of myocardial walls. The aim of this study is to quantify the effect of the wall thickness on EGM amplitudes and duration using analytical and in-silico approaches. Methods We study bipolar EGMs both in-silico and analytically in a homogeneous slab of cardiac tissue (70 x 70 x L mm), where L = 2, 5, or 10 mm, with parallel fiber direction. Simulations were performed using the cardiac electrophysiology simulator openCARP [2]. Cardiac cells were described by the ten Tusscher-Panfilov 2006 model (TP06) [4] with epicardial tissue parameters. A plane wave propagating along the fiber direction was initiated. The extracellular voltage at 147 points arranged in a hemisphere around a point was measured to study the effect of bipolar electrode orientation (see Fig. 1A [3]). In addition, we developed an analytical approach to obtain an EGM, using an equivalent dipole representation of the depolarization wavefront and analytical evaluation of the corresponding integrals. Results Fig. 1B and 1C show the dependency of the EGM properties on the electrode orientation, as represented by the angles α (incidence angle) and β (angle between electrode and propagation direction) [3]. Solid lines represent data from a state-of-the-art numerical methodology, the dashed lines show our analytical estimations. Both the peak-to-peak amplitude and EGM width are well approximated by our theory for all orientations of the electrodes. Fig. 2 shows how the EGM is influenced by the myocardial wall thickness L. Both the amplitude and the duration are in good agreement with our theory. We observe that the amplitude as well as the width increase with the slab thickness, confirming the result in [1] but also delivering an accurate analytical expression for this change. It may thus allow to discriminate effects of thickness and other factors affecting the EGMs, such as substrate abnormalities, for example. Conclusion We developed an analytical approach which can correctly describe the amplitude, duration, and shape of the depolarization part of the EGM. Our theory agrees with the previous in-silico and clinical studies on the influence of catheter orientation [3,5], and wall thickness [1,3]. Subsequent work in this direction is expected to provide better guidelines for clinical interpretation of EGMs, accounting for the effects of the thickness of myocardial wall in the characterization of the substrate of cardiac arrhythmias.

INTERACTION AND VISUALIZATION DESIGN CONSIDERATIONS FOR GAZE-GUIDED COMMUNICATION IN COLLABORATIVE EXTENDED REALITY

Abstract. There is evidence in literature that collaborative work while using digital tools could benefit from visualizing the real time eye movements of a selected participant, or possibly, several participants. In this study, we examine alternative gaze interaction and visualization design prototypes in a digital collaboration scenario, in which assumed collaboration environment is a co-located mixed reality environment. Specifically, we implemented a virtual pointer as a baseline, and representations of gaze as a line, a cursor, and an ‘automated line’ where the line and cursor are automatically alternated based on occlusion detection. These prototypes are then evaluated in a series of usability studies with additional exploratory observations for a spatial communication scenario. In the scenario participants either describe routes to someone else or learn them from someone else for navigational planning. In this paper we describe the alternative interaction design prototypes, as well as various visualization designs for the gaze itself (continuous line and dashed line) and the point of regard (donut, dashed donut, sphere, rectangle) to guide collaboration and report our findings from several usability studies (n=6). We also interviewed our participants which allows us to make some qualitative observations on the potential function and usefulness of these visualization and interaction prototypes. Overall, the outcomes suggest that gaze visualization solutions in general are promising approaches to assist communication in collaborative XR, although, not surprisingly, how they are designed is important.

In Situ Supramolecular Polymerization via Organometallic-Catalyzed Macromolecular Metamorphosis

In Situ Supramolecular Polymerization via Organometallic-Catalyzed Macromolecular Metamorphosis

Accuracy of photoplethysmography-based measurement of blood pressure

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Photoplethysmography (PPG)-based blood pressure (BP) measurements are available in the latest smartwatches and are thus available for patients in the consumer market. While the devices typically comply with the medical device regulation, accuracy is often not known and data on validation are not publicly available. Purpose To investigate the accuracy and precision of the Samsung Galaxy Watch Active 2 PPG-based BP measurement as compared to conventional BP measurement and to investigate clinical applicability. Methods 31 patients scheduled for ambulatory 24-hour BP measurement were included in the study. 24-hour BP devices were attached to the non-dominant arm, smartwatches were attached to the opposite arm. Calibration was performed as instructed by the manufacturer. The smartwatch was used to register BP intermittently for 24 hours. Results from both devices were compared using the Taffé method. Results and discussion Mean age was 59 years. 17 patients (55%) were male. Comparison of the two methods is demonstrated in Figure 1. The smartwatch overestimates the systolic BP up to approximately 132 mm Hg and then underestimates the systolic BP, illustrating the presence of proportional (0.48) and differential (69.0) bias. Precision for the gold standard method was higher compared to the smartwatch measurements. For increasing values of systolic BP, the precision of the smartwatch decreases. For diastolic BP, differential (31.4) and proportional bias (0.68) are present, resulting in an overestimation of the diastolic BP at lower values (<100 mmHg). Precision for the gold standard method was higher at lower BP values, while precision for smartwatch measurements was higher at higher BP values (i.e. there was a lower standard deviation of measurement error). Figure 1 Bias and precision plots for systolic and diastolic blood pressure (BP). In each figure the x-axis indicates the best linear unbiased prediction (BLUP) or true value of BP. Panel A and B indicate the bias plots. Smartwatch measurements (blue dashed lines) are compared to reference measurements (solid black line); both values are read from the leftmost y-axis. The bias (difference of smartwatch measurement compared to the reference method) is depicted as a solid red line; the value of bias is read from the rightmost y-axis. Panel C and D indicate the precision plots, indicating the standard deviation of measurement errors for both measurement methods. The reference method is depicted in black; the smartwatch method is depicted in blue. Conclusion There is a differential and proportional bias in PPG-based BP measurement of systolic and diastolic BP measurement. The systolic BP is overestimated at lower values and underestimated at higher values. This might indicate potential for application as a screening tool for hypertension. Further research is needed to investigate clinical applicability.

Cover Image, Volume 21, Issue 3

Vadose Zone JournalVolume 21, Issue 3 COVER IMAGEFree Access Cover Image, Volume 21, Issue 3 First published: 20 May 2022 https://doi.org/10.1002/vzj2.20207AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract On the cover: Model of the fraction of coarse-dominated material at a site in the Tulare Irrigation District. The preferential flow path depicted by the dashed white line was manually selected using the spatial distribution of units with a high fraction of coarse-dominated material. See Pepin et al., “Managed aquifer recharge site assessment with electromagnetic imaging: Identification of recharge flow paths,” https://doi.org/10.1002/vzj2.20192. Volume21, Issue3May/June 2022 RelatedInformation

MP47-18 SUSTAINABLE MULTIDISCIPLINARY TEAM REFERRAL FOR NON-METASTATIC RENAL CELL CARCINOMA: A SURVIVAL-BASED RECOMMENDATION

You have accessJournal of UrologyCME1 May 2022MP47-18 SUSTAINABLE MULTIDISCIPLINARY TEAM REFERRAL FOR NON-METASTATIC RENAL CELL CARCINOMA: A SURVIVAL-BASED RECOMMENDATION Giuseppe Basile, Alberto Martini, Giuseppe Fallara, Antony Pellegrino, Alessandro Larcher, Daniele Raggi, Riccardo Campi, Sumanta Pal, Philippe Spiess, Francesco Montorsi, Toni K. Choueiri, Andrea Necchi, and Umberto Capitanio Giuseppe BasileGiuseppe Basile More articles by this author , Alberto MartiniAlberto Martini More articles by this author , Giuseppe FallaraGiuseppe Fallara More articles by this author , Antony PellegrinoAntony Pellegrino More articles by this author , Alessandro LarcherAlessandro Larcher More articles by this author , Daniele RaggiDaniele Raggi More articles by this author , Riccardo CampiRiccardo Campi More articles by this author , Sumanta PalSumanta Pal More articles by this author , Philippe SpiessPhilippe Spiess More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , Toni K. ChoueiriToni K. Choueiri More articles by this author , Andrea NecchiAndrea Necchi More articles by this author , and Umberto CapitanioUmberto Capitanio More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002618.18AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To date, multidisciplinary team (MDT) evaluation, enrollment in pre-surgical trials and deferred active treatments are optional strategies for patients with Renal Cell Carcinoma (RCC), which are under investigation to maximize cancer control and implement health care policies. To provide recommendations regarding which patients with RCC may benefit the most from an early MDT evaluation. METHODS: We relied on a prospective dataset including patients diagnosed with RCC in 1998-2019 and treated by means of surgery alone at a tertiary referral center. The risk of other cause mortality (OCM) was evaluated against the risk of recurrence over time by means of the Weibull regression. Patients were stratified based on clinical stage (cT1a; cT1b; cT2; cT3-4), age (<60; 60-70; >70) and comorbidities [Charlson comorbidity index (CCI) 0 vs ≥1]. For each combination of cT stage, age and CCI, the potential need for a MDT referral was defined when the risk of recurrence exceeded the risk of OCM within the lower limit of the 95%CI of the mean time to recurrence. RESULTS: Overall, 1,162 (51%) patients had no comorbidities. Median follow-up was 7 years. Patients who would benefit most from a MDT evaluation are those diagnosed with A) cT3-4 disease (any age or comorbidity) or B) cT2 cancers if healthy and younger than 70 years or younger than 60 years with at least 1 comorbidity or C) cT1b if younger than 60 years and without comorbidities. Figure 1 depicts the risk of other cause mortality versus risk of recurrence following surgery for non-metastatic renal cell carcinoma according to age and cT stage in patients with no comorbidities or in presence of comorbidities. The continuous lines depict the risk of recurrence that decreases with time. Vertical lines depict the mean time to recurrence and associated 95% confidence interval calculated with mean restricted survival time. Dashed lines depict other cause mortality risk, which increases with time. CONCLUSIONS: Our findings can help selecting the optimal candidates for multidisciplinary evaluations and to consider RCC patients for clinical trials, deferred treatment, and treatment policy improvement, especially in the case of major healthcare disruptions, such as pandemics. Source of Funding: None © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e817 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Giuseppe Basile More articles by this author Alberto Martini More articles by this author Giuseppe Fallara More articles by this author Antony Pellegrino More articles by this author Alessandro Larcher More articles by this author Daniele Raggi More articles by this author Riccardo Campi More articles by this author Sumanta Pal More articles by this author Philippe Spiess More articles by this author Francesco Montorsi More articles by this author Toni K. Choueiri More articles by this author Andrea Necchi More articles by this author Umberto Capitanio More articles by this author Expand All Advertisement PDF DownloadLoading ...

A human coronavirus OC43-derived polypeptide causes neuropathic pain.

Human coronaviruses have been recently implicated in neurological sequelae by insufficiently understood mechanisms. We here identify an amino acid sequence within the HCoV‐OC43 p65‐like protein homologous to the evolutionarily conserved motif of myelin basic protein (MBP). Because MBP‐derived peptide exposure in the sciatic nerve produces pronociceptive activity in female rodents, we examined whether a synthetic peptide derived from the homologous region of HCoV‐OC43 (OC43p) acts by molecular mimicry to promote neuropathic pain. OC43p, but not scrambled peptides, induces mechanical hypersensitivity in rats following intrasciatic injections. Transcriptome analyses of the corresponding spinal cords reveal upregulation of genes and signaling pathways with known nociception‐, immune‐, and cellular energy‐related activities. Affinity capture shows the association of OC43p with an Na+/K+‐transporting ATPase, providing a potential direct target and mechanistic insight into virus‐induced effects on energy homeostasis and the sensory neuraxis. We propose that HCoV‐OC43 polypeptides released during infection dysregulate normal nervous system functions through molecular mimicry of MBP, leading to mechanical hypersensitivity. Our findings might provide a new paradigm for virus‐induced neuropathic pain.

Computational Prediction of Graphdiyne-Supported Three-Atom Single-Cluster Catalysts

Computational Prediction of Graphdiyne-Supported Three-Atom Single-Cluster Catalysts

Slow Photon-Enhanced Heterojunction Accelerates Photocatalytic Hydrogen Evolution Reaction to Unprecedented Rates

Slow Photon-Enhanced Heterojunction Accelerates Photocatalytic Hydrogen Evolution Reaction to Unprecedented Rates

Rancangan Strategi Menangani Ancaman Perang Hybrida Melalui Patroli Maritim di Kawasan Laut China Selatan

The ever-changing dynamics in the South China Sea are making international relations even hotter, especially Western countries that feel threatened by China's claims to the South China Sea region with its Nine Dash Line. The South China Sea claimed by China is the North Natuna Sea which is included in the territory of the Republic of Indonesia. Lately the disputed countries use a new strategy of hybrid war that has been waged by the Chinese state in making a coercion by demonstrating capability in terms of strength. This problem makes Indonesia whose territory is affected in the North Natuna Sea must quickly anticipate in response to hybrid warfare by firmly declaring itself as a non-claimant states participating in the arena of dispute in an effort to claimant-states (state parties) in seizing rights in the South China Sea creating an unconventional war called hybrid warfare. One strategy using the SWOT method can conclude that in a prominent variable with opportunities where variables of cooperation with foreign countries greatly help realize the game, security and stability of the region in the Natuna Sea. The strategy used by increasing the variable strength (Strong) and opportunity (Opportunity) so as to increase the security and stability of the NKRI region in the Natuna Sea .

A Polyimide-Based Photocatalyst for Continuous Hydrogen Peroxide Production Using Air and Water under Solar Light

A Polyimide-Based Photocatalyst for Continuous Hydrogen Peroxide Production Using Air and Water under Solar Light

Slow Phase Transition-Induced Scan Rate Dependence of Spin Crossover in a Two-Dimensional Supramolecular Fe(III) Complex

Slow Phase Transition-Induced Scan Rate Dependence of Spin Crossover in a Two-Dimensional Supramolecular Fe(III) Complex

Monitoring Body Length of Hokkaido Native Horse’s Foals Using a Drone

Monitoring Body Length of Hokkaido Native Horse’s Foals Using a Drone

Stable Metal–Halide Perovskite Colloids in Protic Ionic Liquid

Stable Metal–Halide Perovskite Colloids in Protic Ionic Liquid