The aim of this study is to report the excision of a benign tumor of adipose tissue in the submandibular region. A 57-year-old dark-skinned male patient reported increased volume on the left side of his face, with approximately 10 years of evolution. The physical exam showed increased submandibular volume on the left side: a nodule measuring about 10 cm, with a soft and mobile consistency and painless. Fine needle aspiration puncture exam, contrast computed tomography, and ultrasound of the affected site were performed and the result was suggestive of benign tumor of adipose tissue. The patient underwent surgery by submandibular approach and excisional biopsy of the lesion was performed. The tumor presented a yellowish color, measuring 7 cm in its largest diameter. The material was sent for histopathologic examination, which confirmed the diagnosis of lipoma, a benign tumor of adipose tissue. Twelve months of follow-up showed no recurrence or complications.