Damage Process Research Articles

In-plane shear performance and damage evolution of FRP connectors for composite sandwich panels

This study investigated the in-plane shear responses of four types of connectors (single-strand truss, double-strand truss, grid-type, and I-shaped) in precast concrete sandwich panels (PCSPs). The influence of connector type, connector arrangement, and wythe material on the shear performance was discussed through in-plane shear tests and finite element analysis. The failure modes and test results of the four types of connectors were closely related to their shear resistance mechanisms. Changing the connector arrangement method from continuous along the length to discrete arrangement improved connector damage extent and toughness index (TI). The substitution of ordinary concrete with ECC or UHPC in wythes can prevent the wythes failure and enhance peak load (Pm). The finite element (FE) model using the Hashin damage model and randomly generated fibers can accurately capture the shear response of the connectors within PCSP. The damage factor was introduced for quantitative analysis of the damage processes in connectors and wythes and corresponding damage evolution model was developed. Furthermore, the damage evolution model was applied to characterize the degradation of shear stiffness in the load-slip curve, and a load-slip theoretical model that accounted for the progressive development of damage was established.

The Cyclic Performance and Macro-Simplified Analytical Model of Internal Joints in RC-Assembled Frame Structures Connected by Unbonded Prestressed Strands and Mortise-Tenon Based on Numerical Studies

This paper introduces a novel type of connection that integrates unbonded prestressed strands (UPS) and mortise-tenon in an assembly frame structure (UPS-MTF). First, the damage process and failure modes of the joints under reciprocating horizontal loads were systematically analyzed using refined numerical models. The recommended values of the design parameters of the joints were derived from the parametric analysis results. Refined numerical modeling results reveal the diagonal compression strut mechanism within the core region of the joint. The diagonal compression struts model assists in establishing the theoretical calculation formula for the skeleton curve of shear stress–strain in the core region. Second, a genetic algorithm (GA) parameter was identified for the restoring force model of the core region to determine the parameters of the hysteresis rules. Finally, a macro-simplified analytical model of the joint was created based on the restoring force model of the core region, and parameter analysis was conducted to verify the applicability of this macro-simplified analytical model. The research results prove that the damaged form of the joint proposed in this paper originates from the shear and relative slip damage between the components in the core region. The axial compression ratio significantly affects the hysteretic performance of the joints, and the upper and lower limit values were identified for the axial compression ratio of the joints. The area and initial effective stress of the UPS exert a minimal effect on the hysteretic performance of the joint. Based on the method proposed in this paper for determining the restoring force model in the core region of the joints, the hysteresis curves obtained from the macro-simplified analytical model closely match the refined numerical analysis model results. This correspondence verifies the applicability of the macro-simplified analytical model.

Modelling of size-dependent plasticity in polymer-based composites based on nano- and macroscale experimental results

A number of experimental evidences indicate that the local response of polymer matrices near fibres is inadequately represented by classical continuum models relying on the bulk polymer behaviour. This results from size-dependency associated to large plastic strain gradients, complex interphase behaviour and/or changes of polymer structure. Classical multiscale models require artificial tuning of the properties to provide realistic macroscale predictions. We demonstrate that an unprecedented modelling approach based on a micromorphic theory is able to capture such size effects in long-fibre composites. The model is identified via nano digital image correlation strain fields and validated by predicting the strengthening found in transverse compression of UD composites, not captured by classical models. Micro-shear bands are properly regularised by the model, thus correctly handling the size-dependent plasticity and softening effects. The improved prediction of the strain localisation pattern in the matrix opens avenues to more accurately model interfacial failure and damage processes.

Working title: Molecular involvement of p53-MDM2 interactome in gastrointestinal cancers.

The interaction between murine double minute 2 (MDM2) and p53, marked by transcriptional induction and feedback inhibition, orchestrates a functional loop dictating cellular fate. The functional loop comprising p53-MDM2 axis is made up of an interactome consisting of approximately 81 proteins, which are spatio-temporally regulated and involved in DNA repair mechanisms. Biochemical and genetic alterations of the interactome result in dysregulation of the p53-mdm2 axis that leads to gastrointestinal (GI) cancers. A large subset of interactome is well known and it consists of proteins that either stabilize p53 or MDM2 and proteins that target the p53-MDM2 complex for ubiquitin-mediated destruction. Upstream signaling events brought about by growth factors and chemical messengers invoke a wide variety of posttranslational modifications in p53-MDM2 axis. Biochemical changes in the transactivation domain of p53 impact the energy landscape, induce conformational switching, alter interaction potential and could change solubility of p53 to redefine its co-localization, translocation and activity. A diverse set of chemical compounds mimic physiological effectors and simulate biochemical modifications of the p53-MDM2 interactome. p53-MDM2 interactome plays a crucial role in DNA damage and repair process. Genetic aberrations in the interactome, have resulted in cancers of GI tract (pancreas, liver, colorectal, gastric, biliary, and esophageal). We present in this article a review of the overall changes in the p53-MDM2 interactors and the effectors that form an epicenter for the development of next-generation molecules for understanding and targeting GI cancers.

P97 inhibitor promotes apoptosis on colon cancer cells

Background: p97 is a multifunctional protein that plays an important role in DNA damage repair and processes related to programmed cell death. We used CB-5083, a specific p97 inhibitor, to evaluate the effect of inhibiting cluster proliferation and promoting apoptosis on HCT116 colon cancer cells. Materials and methods: Experimental research method used p97 inhibitor CB-5083 (Sellechem) and colon cancer cell line HCT116 (code: CCL-247, ATCC). Colony formation assay and apoptotic assay were used in this study. Data were analysed on ImageJ and GraphPad Prism 9 software. Results: The density and size of cell colonies in the 0.25 µM CB5083 treatment group were statistically significantly smaller than the other groups. The 0.25 µM treatment group had a statistically significant higher percentage of apoptotic cells compared to the 0,125µM group and the control group (p < 0.0001). The percentage of necrotic cells in the 0.125 µM and 0.25 µM treatment groups was statistically significantly higher than the control group (p < 0.0001). Conclusion: Inhibiting p97 by CB5083 suppressed cell colony formation and promoted apoptosis on HCT116 colon cancer cell line. Key words: p97, DNA damage repair, colon cancer, apoptosis.

Study on the Damage and Failure Process of Prefabricated Hole-Fracture Combination Defects in Shale

The rock formations in oil and gas reservoirs are predominantly composed of laminated shale, which contains various defects such as pores and fractures. These defects have a significant impact on the stability of wellbore walls. As a result, this study utilized rock samples from a specific oil and gas reservoir and introduced pre-existing pore and fracture defects within them. Uniaxial compression tests were conducted on rock specimens with varying angles between the fractures and the bedding planes. The study involved measuring and analyzing the impact of pre-existing defect morphology on shale’s mechanical properties. Additionally, through the use of digital image correlation (DIC) technology, a comprehensive strain field map was obtained, depicting the initiation, propagation, and ultimate failure of surface cracks in shale under loading conditions. This allowed for both qualitative and quantitative analysis of the connection between shale’s damage and failure processes and the evolution of strain fields. Ultimately, this research provides a theoretical basis for wellbore stability and the development of shale oil and gas fields. Conclusions drawn from the study are as follows. With an increase in fracture angle, the rock’s elastic modulus gradually increases, and both compressive strength and strain exhibit a pattern of higher values on both ends and lower values in the middle. When the fracture angle is less than 30°, significant stress concentration occurs at the tip of the fracture. When the angle exceeds 60°, stress concentration around pores dominates. In the range of 30° to 60°, there is a combined stress concentration around both pores and fractures, significantly reducing rock stability. Crack propagation is influenced by bedding planes and exhibits varying degrees of ductility, ultimately resulting in a tension-shear mixed failure. When fractures are parallel to bedding planes (angle = 0°), defects are symmetrically distributed, and stress concentration at the fracture tip dominates, leading to crack initiation from the fracture tip and eventually forming an “H”-shaped tensile failure. When fractures are perpendicular to bedding planes (angle = 90°), stress concentration around pores is greater than at the fracture tip, causing cracks to initiate around pores and eventually collapsing on one side of the fracture.

A Population-Based Tumor-Volume Model for Head and Neck Cancer During Radiation Therapy With a Dynamic Oxygenated Compartment

PurposeWith the coming era of digital wisdom medical technology, mathematical modelling of tumor becomes a key step to optimize and realize precision radiotherapy. The purpose of this study is to develop a mathematical model for simulating the change of head-and-neck tumor (HN) volume during radiotherapy. Methods and MaterialsA formula is developed to describe the dynamic change of oxygenated compartment within a tumor, which is combined with the LPL model to describe various cell processes during radiotherapy, including potentially lethal lesion repair and misrepair, cell proliferation/loss, and tumor reoxygenation. Parameter sensitivity analysis is performed to evaluate the impacts of the lesion-related and repair-related biological factors on radiotherapy outcome. ResultsWe tested our model on 14 available HN cancer patients and compared the performance with three other models. The mean error of our model for the twelve good fit cases is 12.2%, which is considerable smaller than that of the LQ model (19.7%), GLQ model (19.1%) and FLCP model (16.6%). Correlation analysis results reveal that for small tumors, there is a positive correlation (correlation coefficient r=0.9416) between hypoxic fraction and tumor volume, whereas the correlation becomes negative and not significant (r=−0.4365) for large tumors. It is demonstrated from sensitivity analysis that the production rate of lethal lesions (ηl) has a far greater impact on tumor volume than other parameters. The hypoxic fraction has insignificant impact on tumor volume, but it has notable influence on the volume of surviving cells. The final volume of surviving cells athf=0.5 is almost 8 ×102 times that of hf=0.01. The potentially lethal lesion-related parameters (ηpl,εpl, ε2pl) have rather small impacts (<1%) on both tumor volume and the volume of surviving cells, which indicates that the repaired and misrepaired sublethal cells only take up a small portion of the total cancer cell population. ConclusionsA population-based tumor-volume model for HN cancer during radiotherapy with a dynamic oxygenated compartment was developed in this study. Comprehensively considering the damage process of tumor cells caused by radiation therapy, the accurate prediction of the volume change of head-and-neck tumors during treatment has been revealed. Meanwhile, various cell activities and their principles in the process of anti-tumor treatment were reflected, and it has positive clinical reference significance for radiobiology.

Simulation Study on Defect Damage Behavior of Fe under Irradiation Environment

Abstract As a commonly used structural material in nuclear power plants, Reactor pressure vessel (RPV) steel is subjected to high-energy neutron irradiation from the reactor core for a long time, and the service environment is harsh. The accumulation of point defects (interstitial atoms and vacancies) generated by irradiation over a long period can seriously affect the microstructure of the material. The macroscopic properties of the material changed until the material failed, which threatened the safety and operation stability of nuclear power plants. This paper used the method of molecular dynamics to simulate the cascade collision process of Fe in the irradiation environment. The relationship between different factors and radiation damage defects was studied. Firstly, the quantity of the Frenkel pairs increases rapidly in the irradiation environment, and then recombination occurs after reaching the peak, which makes the quantity of the Frenkel pairs decrease rapidly. Finally, the quantity of Frenkel pairs is in a stable trend. When PKA energy and temperature increase, the higher the quantity of Frenkel pairs at the peak is, the higher the recombination rate of defects is. Meanwhile, the larger the cluster size of interstitial atoms and vacancies is, the greater the corresponding quantity of clusters is. As PKA energy increases, the quantity of residual Frenkel pairs at stability increases, while the number of residual Frenkel pairs at stability decreases with temperature. This is attributed to the intense thermal motion of molecules at high temperatures, resulting in the quantity of Frenkel pairs decreasing at the stable stage. Therefore, by simulating the irradiation damage process of Fe, the prediction of material irradiation damage under a neutron irradiation environment is provided, and the service life of materials can be provided with theoretical guidance.

Effects of orientation angle of spectrum-compatible bidirectional ground motions on nonlinear seismic response of bridge piers considering progressive damage process

Effects of orientation angle of spectrum-compatible bidirectional ground motions on nonlinear seismic response of bridge piers considering progressive damage process

Revealing evolution law and failure mechanism of interface damage in concrete-encased CFST columns by acoustic emission technology

Concrete-Encased Concrete-Filled Steel Tubular (CFST) has extensive applications in high-rise buildings and bridge engineering as a high-performance composite structure. The severe bond failure between Concrete-Filled Steel Tubular and the outer concrete poses a significant threat to the integrity and safety of the structure. Considering the concealed and random nature of interface damage, this study proposes a real-time monitoring and evaluation method for Concrete-Encased CFST interface damage based on acoustic emission (AE) technology. Four groups of experiments on Concrete-Encased CFST column interface shear was conducted to investigate the influence of the number of shear connectors on the bond failure mechanism between CFST and the outer concrete. The signal characteristics of three kinds of AE sensors with different operating frequency ranges were analyzed to guide the selection of sensors according to the monitoring targets. The structural damage development trend has been recognized by analyzing the change rule of AE feature parameters. RA-AF correlation analysis has been used to identify the evolution law of cracks and the failure mechanism of the structure. The b-value analysis has been used to evaluate the damage severity of the structure. From the above three aspects, the damage evolution law and failure mechanism of the interface can be revealed. The results indicate that the R3α sensor is suitable for early warning of damage, the R15α sensor can be used for monitoring and warning of structural failure, and the R6α sensor can be used to describe and evaluate the whole process of damage. Based on the features of AE hit rate, cumulative hits, and cumulative energy, the damage process of Concrete-Encased CFST column interface can be accurately divided into the elastic stage, local slip stage, shear connector fracture stage, and slip stage. The RA-AF correlation analysis showed that the shear cracks were detected to develop rapidly before the peak load, and a significant number of tensile cracks caused by cracking of the outer concrete appear around the peak load. The changes of b-value can effectively reflect the magnitude of damage and record the occurrence of major damage.

A new approach for fracture process zone evaluation

The study presents a novel method for identifying and monitoring the fracture process zone and its impact on cracking parameters, such as damage rate and fracture energy. Concrete samples subjected to a Wedge Splitting Test were investigated. Digital Image Correlation, a full-field measurement technique, was utilized to measure the experimental displacement fields at various scales. The experimental measurements, optimized through a Newton-Raphson iterative adjustment procedure, revealed the presence of a damaged zone accompanying the cracking process. This analysis also enabled the estimation of the material damage rate and provided a more realistic assessment of cracking parameters by integrating the entire process of damage and macro-cracking into the calculation of fracture energy. The results suggest that the appearance of a fracture process zone correlates with a reduction in the material’s hardness downstream of the crack propagation front.

Peridynamic simulation of micro-internal damage and macro-mechanical properties of cement paste under freeze-thaw cycles

Concrete is a multi-phase, multi-component, heterogeneous composite material and a typical porous medium with a complex microstructure. Under freeze-thaw cycles (FTCs), pressures from the freezing and migration of water within the pores of the concrete cause freeze-thaw damage, which is influenced by its microstructure. To effectively simulate and understand the freeze-thaw damage mechanism, it is crucial to use a geometric structure that reflects the actual pore distribution. This study employs the μic model to create a geometric structure of hardened cement paste, capturing the spatial distribution of pores. The study utilizes the peridynamics (PD) method based on ice formation and crystallization thermodynamics to investigate the freeze-thaw damage evolution and the deterioration of mechanical properties in cement paste under FTCs. The simulations revealed the entire freeze-thaw damage process of cement paste, including internal crack initiation and propagation, as well as surface freeze-thaw spalling. The freeze-thaw damage of cement paste intensifies with increasing FTCs, and the extension of cracks diminishes the interconnection among the skeletons constituting the cement paste microstructure, leading to decreased tensile strength and elastic modulus. Additionally, the stress-strain evolution behavior of freeze-thaw cement paste under uniaxial tensile loads was obtained. The tensile strength and elastic modulus of cement paste decrease with increasing FTCs, and the higher the water-cement (w/c) ratio, the greater the reduction in strength and modulus.

Identification of Environmental Damage Process of a Chromium-Contaminated Site in China

Identification of Environmental Damage Process of a Chromium-Contaminated Site in China

New insights into sodium phenylbutyrate as a pharmacotherapeutic option for neurological disorders.

Neurological disorders (NDs) are diseases of the central and peripheral nervous systems that affect more than one billion people worldwide. The risk of developing an ND increases with age due to the vulnerability of the different organs and systems to genetic, environmental, and social changes that consequently cause motor and cognitive deficits that disable the person from their daily activities and individual and social productivity. Intrinsic factors (genetic factors, age, gender) and extrinsic factors (addictions, infections, or lifestyle) favor the persistence of systemic inflammatory processes that contribute to the evolution of NDs. Neuroinflammation is recognized as a common etiopathogenic factor of ND. The study of new pharmacological options for the treatment of ND should focus on improving the characteristic symptoms and attacking specific molecular targets that allow the delay of damage processes such as neuroinflammation, oxidative stress, cellular metabolic dysfunction, and deregulation of transcriptional processes. In this review, we describe the possible role of sodium phenylbutyrate (NaPB) in the pathogenesis of Alzheimer's disease, hepatic encephalopathy, aging, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis; in addition, we describe the mechanism of action of NaPB and its beneficial effects that have been shown in various in vivo and in vitro studies to delay the evolution of any ND.

Climate Displacement in Pakistan: (under) reported Frame in Media Discourse on Climate Change in Pakistan

Climate disruption has brought irreversible damage to the world. Since global communities are being widely affected by these changes, masses of the populations are facing climate induced displacement. Such displacements involve internal as well as cross border migration. Climate change is marginalized issue in the hand of media in Pakistan, making climate induced displacement doubly underreported. This study focuses on the media coverage of climate change displacement in Pakistani media discourse. The key research objectives include; to find frequency of climate related news during flood coverage in Pakistan, to assess the nature of themes covered while reporting flood related news during defined period of time and to find climate change induced displacement in media coverage of floods in Pakistan. This study uses content analysis as a research method. Time frame focused in the current study involves 15th June 2022 to 15th September 2022, when flood hit major part of Pakistan. Findings of the study reveal that during defined period of time climate change induced displacement remained under reported in Pakistani newspapers (Dawn, The Nation and The Express Tribune). Moreover, while covering irregular weather events pertaining to climate change, main focus remained on damage, government criticism and aid related process.

Analysis of Damage Process in a Pre-Notched Rock Specimen: The Synergy between Experimental Results and Simulations Using a Peridynamic Model

Analysis of Damage Process in a Pre-Notched Rock Specimen: The Synergy between Experimental Results and Simulations Using a Peridynamic Model

Banana fruit bruise detection using fractal dimension based image processing

The study used the fractal dimension (FD), browning incidence, and grayscale values using machine vision to describe the bruise magnitude and quality of mechanically damaged ‘Fard’ bananas bruised from 20, 40, 60 cm drop heights by 66, 98, and 110 g ball weights conditioned at different storage temperatures (5, 13, 22 °C) after 48 h. Conventional analyses like bruise area (BA), bruise volume (BV), and bruise susceptibility (BS) were also conducted. A correlation was performed to determine the relationship between image processing and conventional assessment of bruise damage in bananas. Weight, firmness, color, sugar content, and acidity were investigated. The results demonstrated that bananas bruised from the highest force and stored at 5 and 22 °C reported the lowest FD with values of 1.7162 and 1.7403, respectively. Increasing the level of damage reduced the fractal dimension and grayscale values and increased browning incidence and bruise susceptibility values after 48 h of storage. The total color change values showed a strong Pearson's correlation coefficient (r≥-0.81) with image analysis fractal dimension and grayscale values. The findings also indicated that higher bruising and temperature can induce weight loss, firmness reduction, lightness, and yellowness increment, and sugar and acidity changes. Overall, the fractal image analysis conducted in this study was highly effective in describing the bruising magnitude of bananas under different conditions.

Brittle Damage Processes Around Equi‐Dimensional Pores or Cavities in Rocks: Implications for the Brittle‐Ductile Transition

AbstractIn the Earth's upper crust, rocks deform mostly by means of brittle fracturing processes. At the micro‐scale these processes involve the formation and growth of microcracks in the vicinity of defects such as open fissures, pores and other cavities. Large defects can produce strong enough perturbations of the stress field to activate and/or intensify brittle damage around them. Here we considered the ideal cases of smooth cylindrical and spherical pores inside an infinite solid body subjected to remote triaxial compressive stresses (i.e., the intermediate and minimum principal stresses are assumed equal). We first established the resulting local stress field around one of those large pores and then verified whether certain brittle damage processes could be activated in these conditions. We mainly considered the formation of tensile microcracks and micro shear bands. The former requires the presence of tensile stresses in some regions around the pore, while the latter needs sufficiently large shear stresses on pre‐existing optimally inclined microcracks to overcome their frictional resistance to sliding. We find that shear driven deformation remains localized in the vicinity of the pore. On the other hand, dilatational, tensile cracks can propagate large distances away from the pore but cannot form at and above some threshold ratio of the least to the largest principal stresses. Faulting associated with interacting tensile cracks is therefore suppressed with increasing depth. Our analysis leads to conclusions generally consistent with published experimental observations and provides some clues to discuss the physical cause of the brittle‐ductile transition in rocks.

Performance based concrete quality assessment with gas permeability testing on site

In terms of sustainability and durability, performance-based design is becoming increasingly important for the quality assessment of concrete structures. Up to now, prescriptive approaches for concrete composition and processing and the determination of concrete strength on cast samples have primarily been used as quality assurance. As this does not take into account the quality and pore structure of the as-built concrete cover, which has a significant influence on durability as a protective zone against penetrating media, the conventional approach to quality control is not representative for this zone. In particular, the permeability of the concrete cover, which is largely dependent on the pore structure, is responsible for the ability of aggressive substances from the environment to ingress into the concrete and, depending on its quality, determines damage processes in the reinforced concrete, such as carbonation. For this reason, investigations to gas permeability on real structures are presented here, which include the possibilities and limitations of measuring and evaluating gas permeability as a durability indicator. Long-term observation was carried out on concrete walls of a motorway construction site, from a young concrete age of 14 days to a higher age of max. 800 days, in order to determine changes in the material structure of the surface area and to analyse their influence on the gas permeability. The concrete walls were treated in advance during hydration up to an age of 7 days with different curing times and types in order to simulate good, medium and poor concrete surfaces. Clear differences in the quality of the concrete cover could already be determined by means of gas permeability. The influence of the surface structure, the effect of the environment and the long-term development of the concrete structure on the permeability are also addressed in this work.

Therapeutic potential of urine-derived stem cells in renal regeneration following acute kidney injury: A comparative analysis with mesenchymal stem cells.

Acute kidney injury (AKI) is a common clinical syndrome with high morbidity and mortality rates. The use of pluripotent stem cells holds great promise for the treatment of AKI. Urine-derived stem cells (USCs) are a novel and versatile cell source in cell-based therapy and regenerative medicine that provide advantages of a noninvasive, simple, and low-cost approach and are induced with high multidifferentiation potential. Whether these cells could serve as a potential stem cell source for the treatment of AKI has not been determined. To investigate whether USCs can serve as a potential stem cell source to improve renal function and histological structure after experimental AKI. Stem cell markers with multidifferentiation potential were isolated from human amniotic fluid. AKI severe combined immune deficiency (SCID) mice models were induced by means of an intramuscular injection with glycerol. USCs isolated from human-voided urine were administered via tail veins. The functional changes in the kidney were assessed by the levels of blood urea nitrogen and serum creatinine. The histologic changes were evaluated by hematoxylin and eosin staining and transferase dUTP nick-end labeling staining. Meanwhile, we compared the regenerative potential of USCs with bone marrow-derived mesenchymal stem cells (MSCs). Treatment with USCs significantly alleviated histological destruction and functional decline. The renal function was rapidly restored after intravenous injection of 5 × 105 human USCs into SCID mice with glycerol-induced AKI compared with injection of saline. Results from secretion assays conducted in vitro demonstrated that both stem cell varieties released a wide array of cytokines and growth factors. This suggests that a mixture of various mediators closely interacts with their biochemical functions. Two types of stem cells showed enhanced tubular cell proliferation and decreased tubular cell apoptosis, although USC treatment was not more effective than MSC treatment. We found that USC therapy significantly improved renal function and histological damage, inhibited inflammation and apoptosis processes in the kidney, and promoted tubular epithelial proliferation. Our study demonstrated the potential of USCs for the treatment of AKI, representing a new clinical therapeutic strategy.