Damage Model Research Articles

A reduced cluster dynamics modeling of radiation damage in tungsten

A reduced cluster dynamics modeling of radiation damage in tungsten

Seismic Collapse Risk Assessment and Fragility Analysis of Reinforced Masonry Core Walls with Boundary Elements Using the FEMA P695 Methodology

In the past, the primary objective of structural design codes was centred around ensuring human life safety, with a strong focus on preventing structural collapse. This approach predominantly relied on force- or strength-based criteria as the basis for design. Nevertheless, a notable shift has occurred recently, transitioning the design philosophy from 'strength' towards a 'performance'-based approach. This shift signifies a growing recognition that strength and performance are not identical. However, to adopt the performance-based seismic design approach, it is essential to develop precise models for estimating damage and potential losses associated with various seismic force-resisting systems (SFRSs). Fragility functions are widely interpreted among the most prevalent damage and loss models. They establish a crucial link between specific demand parameters and the likelihood of exceeding various damage states. Although reinforced masonry (RM) structures have recently gained popularity, the seismic design of mid- to high-rise RM structures is still challenging because it requires a reliable SFRS capable of providing the needed ductility and capacity. Therefore, the main objective of this study is to evaluate the key seismic performance parameters (i.e., system overstrength and ductility) and to perform a collapse capacity risk assessment of reinforced masonry core walls with boundary elements (RMCW+BEs) as the main SFRS in RM structures. The current study utilizes the applied element method (AEM) implemented in the Extreme Loading for Structures software (ELS) to model three RM structures with various heights (10-, 15-, and 20-story buildings). Nonlinear pseudo- static pushover analysis was performed to quantify the ductility and overstrength of the proposed RM system following the FEMA P695 guidelines. In addition, an incremental dynamic analysis (IDA) was carried out to assess the seismic collapse risk of RMCW+BEs by generating system-level-based fragility curves. The results showed that the proposed RM system provides the needed ductility, overstrength and deformation capacity for a ductile SFRS for typical mid- and high-rise RM buildings. Furthermore, the developed collapse fragility curves verified excellent seismic performance, negligible collapse probability values and high reserved collapse capacity at the maximum considered earthquake (MCE) design level. The findings of this study significantly contribute toward adopting RMCW+BEs as an effective SFRS for typical RM buildings in the next generations of North American masonry design standards.

Seismic Collapse Risk Assessment and Fragility Analysis of Reinforced Masonry Core Walls with Boundary Elements Using the FEMA P695 Methodology

In the past, the primary objective of structural design codes was centred around ensuring human life safety, with a strong focus on preventing structural collapse. This approach predominantly relied on force- or strength-based criteria as the basis for design. Nevertheless, a notable shift has occurred recently, transitioning the design philosophy from 'strength' towards a 'performance'-based approach. This shift signifies a growing recognition that strength and performance are not identical. However, to adopt the performance-based seismic design approach, it is essential to develop precise models for estimating damage and potential losses associated with various seismic force-resisting systems (SFRSs). Fragility functions are widely interpreted among the most prevalent damage and loss models. They establish a crucial link between specific demand parameters and the likelihood of exceeding various damage states. Although reinforced masonry (RM) structures have recently gained popularity, the seismic design of mid- to high-rise RM structures is still challenging because it requires a reliable SFRS capable of providing the needed ductility and capacity. Therefore, the main objective of this study is to evaluate the key seismic performance parameters (i.e., system overstrength and ductility) and to perform a collapse capacity risk assessment of reinforced masonry core walls with boundary elements (RMCW+BEs) as the main SFRS in RM structures. The current study utilizes the applied element method (AEM) implemented in the Extreme Loading for Structures software (ELS) to model three RM structures with various heights (10-, 15-, and 20-story buildings). Nonlinear pseudo- static pushover analysis was performed to quantify the ductility and overstrength of the proposed RM system following the FEMA P695 guidelines. In addition, an incremental dynamic analysis (IDA) was carried out to assess the seismic collapse risk of RMCW+BEs by generating system-level-based fragility curves. The results showed that the proposed RM system provides the needed ductility, overstrength and deformation capacity for a ductile SFRS for typical mid- and high-rise RM buildings. Furthermore, the developed collapse fragility curves verified excellent seismic performance, negligible collapse probability values and high reserved collapse capacity at the maximum considered earthquake (MCE) design level. The findings of this study significantly contribute toward adopting RMCW+BEs as an effective SFRS for typical RM buildings in the next generations of North American masonry design standards.

Construction of an intelligent pH-sensitive hydrogel drug delivery system and its application in gastric ulcer treatment

The occurrence of gastric ulcer is mainly due to the damage of gastric mucosa which leads to inward flow of gastric acid to corrode the gastric cavity, thus producing gastric fever, vomiting, loss of appetite and other adverse reactions. Prevention and treatment of such injuries are crucial. In this study, a simple and non-toxic composite hydrogel (PLGA/CMCS) was prepared through Schiff base reaction between poly(lactic-co-glycolic acid) (PLGA) and carboxymethyl cellulose (CMCS). Subsequently, compound 1 was loaded onto it to construct PLGA/CMCS@1. A series of structural characterization and performance experiments were conducted on these novel hydrogel polymers. Furthermore, we detected the gene expression level of Fas/FasL apoptotic pathway after treating the cells with different concentrations of PLGA/CMCS@1 through an ethanol-induced damaged gastric mucosal epithelial cell model. The results showed that the system was able to significantly regulate the expression of genes related to the apoptotic pathway. The system can regulate the Fas/FasL apoptosis pathway to treat gastric ulcer.

Studying the Constitutive Model of Damage for a Stainless Steel Argon–Oxygen Decarburization Slag Mixture

The purpose of this study was to fully explore the mechanical properties of five different doses of an Argon–Oxygen Decarburization slag mixture in an unconfined compressive strength test. The peak stress, elastic modulus, and stress–strain curve of the mixture were studied for 90 days. Based on the experimental data and according to the theory of damage mechanics, the concept of damage threshold (t) was introduced to construct a damage constitutive model. Referring to the damage threshold of concrete, that of the mixture was determined to be 0.7 times higher than the peak strain, and the correlation coefficient between the established model and the test curve was above 0.85. These results indicate that the addition of AOD slag and fly ash can cause hydration reactions, increase the quantity of hydration products, and enhance the peak stress and elastic modulus of the mixture. The maximum increases were 94.9% and 43.1%, respectively. Parameters a and b reflect the peak stress and brittleness of the mixture, respectively. The incorporation of Argon–Oxygen Decarburization slag can make the mixture less brittle and improve its properties. The incorporation of Argon–Oxygen Decarburization slag can protect the mixture from damage. The maximum decrease is 40.2%.

Creep-thermal fatigue behavior of thin-walled structures with holes and a creep-thermal fatigue-oxidation phase field model

An experiment was conducted to evaluate the creep-thermal fatigue (CTF) behavior of thin-walled structures with holes. To achieve this, a high-temperature hold phase was added in the testing. The crack propagation of CTF is driven by the combined effects of creep, thermal fatigue, and oxidation. Therefore, a creep-thermal fatigue-oxidation phase field model was developed to simulate CTF behavior. The model accounts for the interaction between creep damage and fatigue damage, as well as the oxidation effect. A creep degradation function was formulated based on classical damage theory, and two creep damage models were compared. Two physically meaningful strategies were proposed to describe oxidation-induced fatigue damage. Finally, the applicability of model to creep-fatigue was validated.

Protopine Exerts Neuroprotective Effects on Neonatal Hypoxic-Ischemic Brain Damage in Rats via Activation of the AMPK/PGC1α Pathway.

Neonatal hypoxic-ischemic encephalopathy (HIE), caused by perinatal asphyxia, is characterized by high morbidity and mortality, but there are still no effective therapeutic drugs. Mitochondrial biogenesis and apoptosis play key roles in the pathogenesis of HIE. Protopine (Pro), an isoquinoline alkaloid, has anti-apoptotic and neuro-protective effects. However, the protective roles of Pro on neonatal hypoxic-ischemic brain injury remain unclear. In this study, we established a CoCl2-induced PC12 cell model in vitro and a neonatal rat hypoxic-ischemic (HI) brain damage model in vivo to explore the neuro-protective effects of Pro and try to elucidate the potential mechanisms. Our results showed that Pro significantly reduced cerebral infarct volume, alleviated brain edema, inhibited glia activation, improved mitochondrial biogenesis, relieved neuron cell loss, decreased cell apoptosis and reactive oxygen species (ROS) after HI damage. In addition, Pro intervention upregulated the levels of p-AMPK/AMPK and PGC1α as well as the downstream mitochondrial biogenesis related factors, such as nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factor A (TFAM), but the AMPK inhibitor compound c (CC) could significantly reverse these effects of Pro. Pro may exert neuroprotective effects on neonatal hypoxic-ischemic brain damage via activation of the AMPK/PGC1α pathway, suggesting that Pro may be a promising therapeutic candidate for HIE, and our study firstly demonstrate the neuro-protective roles of Pro in HIE models.

Evaluation and optimization of interventional blood pump based on hydraulic performances and hemocompatibility performances

This study was designed to investigate the effects of hemodynamic environment and design factors on the hydraulic performance and hemocompatibility of interventional blood pumps using computational fluid dynamics methods combined with specialized mathematical models. These analyses assessed how different hemodynamic environments (such as support mode and artery size) and blood pump configurations (including entrance/exit blade angles, rotor diameter, blade number, and diffuser presence) affect hydraulic performance indicators (rotational speed, flow rate, pressure head, and efficiency) and hemocompatibility indicators (bleeding, hemolysis, and thrombosis). Our findings indicate that higher perfused flow rates necessitate greater rotational speeds, which, in turn, reduce both efficiency and hemocompatibility. As the artery size increases, the hydraulic performance of the pump improves but at the cost of worsening hemocompatibility. Among the design parameters, optimal configurations exist that balance both hydraulic performance and hemocompatibility. Notably, a configuration without a diffuser demonstrated better hydraulic performance and hemocompatibility compared to one with a diffuser. Further analysis revealed that flow losses primarily contribute to the degradation of hydraulic performance and deterioration of hemocompatibility. Shear stress was identified as the major cause of blood damage in interventional blood pumps, with residence time having a limited impact. This study comprehensively explored the effects of operating environment and design parameters on catheter pump performance using a multi-faceted blood damage model, providing insights into related complications from a biomechanical perspective. These findings offer valuable guidance for engineering design and clinical treatment.

A validated simulation methodology for determining single lap shear allowable strength in thermoplastic polymer composites

While several modeling approaches exist to simulate the strength of single lap shear configurations, their application to obtaining design allowables for thermoplastic composites remains underexplored. This paper addresses this gap by presenting a novel methodology for the forward propagation of parameter uncertainty using advanced finite element models specifically tailored for thermoplastic carbon fiber composites. The proposed approach goes beyond traditional methods by integrating advanced damage models and a structured validation process, supported by an extensive experimental test campaign.We demonstrate the feasibility of determining design allowables through simulation by examining the influence of batch size on both the validation process and the prediction of allowable strength. Our findings provide new insights into the propagation of uncertainties in the context of composite material design, showing that it is possible to achieve reliable design allowables through simulation, which can significantly accelerate the development of new components while maintaining high safety standards.

Effect of initial temperature damage on the static and fatigue performance of all-lightweight shale ceramsite concrete

The effects of initial temperature damage on the static and compressive fatigue properties of LC30 all-lightweight shale ceramsite concrete (ALWSCC) were studied. The curing conditions ranged from -5 °C to -30 °C without antifreeze, with an elevated temperature range of 100 °C to 400 °C applied after 28 days of standard curing. We tested the static strength, elastic modulus, and stressstrain curves of ALWSCC, as well as its uniaxial compression fatigue life and ƐN curves under different stress levels. The credibility of data from only three test samples per condition was statistically analyzed, and we explored how temperature, aggregate properties, and concrete pore structure affect performance. The results indicate that the impact of temperature on the static and fatigue performance of ALWSCC can be described by a unified damage model. The Hillerborg characteristic length effectively captures the brittleness induced by temperature changes. Using the two-parameter Weibull equation and various fatigue equations that account for failure probability and temperature, the fatigue life predictions were accurate. Although low and high temperatures affect ALWSCC differently, temperature effects combined with static and fatigue loads further accelerate its deterioration.

Mito-TEMPO Demonstrates Protective Effect Against Ultraviolet Radiation-Induced Skin Damage in Wistar Rats.

Mitochondria could be an important target for ultraviolet radiation (UVR)-induced skin damage. Therefore, protecting mitochondria using mitochondria-targeted antioxidants may protect skin from UV-induced photodamage. In the present study, UVR-induced skin damage model was developed by irradiating male Wistar rats with UVB at a dose of 120 mJ/cm2, twice a week for a period of 5 weeks. Mito-TEMPO was administered intraperitoneally (0.1 mg/kg b.w.) twice a week for 5 weeks. After 5 weeks of treatment period, animals were sacrificed and the dorsal skin tissues were collected. Physical examinations of the skin for analyzing wrinkle formation and epidermal thickening were carried out. Skin tissues were used for the evaluation of histopathological changes, mitochondrial dysfunction analysis, and mitochondrial membrane potential. Physical and histological examination showed that mito-TEMPO protected from the damaging effect of UVB radiation. A significant increase in mitochondrial reactive oxygen species (mtROS) generation with a concomitant increase in mitochondrial lipid peroxidation (mtLPO) was observed in UV-irradiated groups. UV-induced generation of mtROS and mtLPO formation was effectively reduced by mito-TEMPO. Mito-TEMPO pre-treatment improved mitochondrial complex II activity, which was significantly reduced in the UV-irradiated group. The results suggested that mito-TEMPO effectively protected skin tissue against UV-induced oxidative stress and damage.

Experimental and numerical investigation on the failure behaviors of laminates with various shaped cutouts under tensile loading

Composite structures in aircraft often contain many cutouts, and failure of these structures is prone to occur near the edge of cutouts. Therefore, the failure behaviors of laminates with various shaped cutouts should be carefully investigated. To this end, experiments and numerical simulations are employed to investigate this issue. The tensile tests of composite laminates with circular, elliptical, square, and rectangular cutouts were carried out. Digital image correlation was utilized to capture the strain fields around the cutout. Combining the strain failure criterion and the modified exponential damage variables a three-dimensional progressive damage model was established, which can accurately predict the peak loads of composite laminates with diverse cutouts. All errors between the experimental and numerical results are less than 10 %. The experimental and numerical results indicate that the shape of the cutout has a great influence on the peak loads. As the ratio of major axis to minor axis (a/b) is increased from 1 to 5, peak loads obviously increase for the laminates with elliptical cutouts. Experimental results show that the average peak load of the laminates with elliptical cutout (a/b = 4) is 20.0 % higher than that of the laminates with circular cutout (a/b = 1). The dispersed distribution of high strains near the edge of the cutout results in an improvement of bearing capacity. As the ratio of length to width (l/w) in rectangular cutouts is increased from 0.5 to 3, peak loads are also improved obviously, because experimental results show that the average peak load of the laminates with rectangular cutout (l/w = 0.5) is 12.3 % lower than that of the laminates with square cutout (l/w = 1). Therefore, to improve the peak loads, it is very necessary to select the proper ratios of a/b and l/w. The above conclusions can serve as a reference for the design of composite structures.

Characteristics of Particle-Wet Wall Impact Damage: Effects of Liquid Film Parameters

Particle impact damage significantly affects the safe and stable operation of energy and chemical process equipment. During particle transportation, a liquid film may form on the wall, influencing the damage mechanism caused by particle effect. This study investigates the effects of liquid film parameters, specifically viscosity and thickness, on wall damage. Hydroxypropyl Methylcellulose (HPMC) solution was applied as a liquid film, and the effect of the liquid film's viscosity and thickness was examined through impact damage experiments using a particle (45 steel) and a wall (1060 aluminum alloy) with the liquid film. Results indicate that the presence of a liquid film can inhibit wall damage. Increased liquid film viscosity and thickness reduce wall damage, but they affect the turning points of damage characteristic parameters differently concerning impact angle and velocity. Finally, the study establishes correlation between dry and wet impact by introducing the effect coefficient of liquid film. This reveals the alteration rules of the influence coefficient and proposes a wet impact damage model, providing a reference for the damage prediction in process equipment.

Numerical study of delamination process of the CFRP composite

A quasi-static approach for an interface damage model, incorporating Rayleigh damping for viscoelastic carbon fiber reinforced polymer composites, is introduced. The interface traction-relative displacement behavior is modeled using a thin adhesive layer, similar to cohesive zone models. The problem is solved numerically with a semi-implicit time-stepping method. The cohesive interface model, integrated into the Finite Element Method, was applied to determine the critical force away from the crack tip. Results showed that the numerical delamination under mode I conditions aligned well with experimental data for the cohesive zone formulations studied. The numerical example demonstrates the effectiveness of the proposed model.

Coupled effects of hygrothermal degradation and fatigue damage of sheet molding compound (SMC) composite

Industrial sheet molding compound (SMC) composite structures are susceptible to environmental degradation, primarily from moisture and temperature. Furthermore, these materials are subjected to fatigue loading. It is therefore necessary to generate Wohler curves for a range of service conditions, taking into account exposure time and temperature. Given the time-consuming nature of these preliminary characterizations, this paper presents an innovative approach to rapid fatigue life prediction using both monotonic and fatigue tests. The core concept of the proposed model is to establish an equation of state that correlates first-cycle macroscopic damage to fatigue life. By coupling this relationship with micromechanical modelling of quasi-static damage, we can rapidly determine SN curves for any considered aged state. The methodology also integrates the microstructure as an input, significantly reducing the need for extensive experimental characterization. A comparison between experimental and simulated Wöhler curves shows excellent agreement over different ageing conditions for SMC composites.

5-Demethylnobiletin Ameliorates Isoproterenol-Induced Cardiac Fibrosis and Apoptosis by Repressing the Sirt1/FOXO3a/NF-κB and Wnt/β-Catenin Pathways.

Apoptosis and fibrosis are two main factors leading to heart failure. 5-Demethylnobiletin (5-OH-Nob) is a natural polymethoxyflavone derived from the peel of citrus fruits that has many biological effects, such as antioxidative stress and anti-inflammatory effects. Here, we aimed to probe the function and mechanism of 5-OH-Nob in myocardial damage. Primary rat cardiac fibroblasts were exposed to isoproterenol (ISO, 10 µM) to establish an in vitro model of cardiac damage, and ISO (30 mg/kg/d) was used to induce myocardial fibrosis in mice. 5-OH-Nob was used for treatment in vivo and ex vivo. Functional assays revealed that 5-OH-Nob alleviated the apoptosis and fibrosis of cardiac fibroblasts treated with ISO and increased cell viability (p < 0.05). In vivo, 5-OH-Nob treatment ameliorated cardiac injury in ISO-treated mice (p < 0.05). Mechanistically, 5-OH-Nob treatment enhanced Sirt1 expression and suppressed ISO-mediated activation of the FOXO3a/nuclear transcription factor-κB (NF-κB) and Wnt/β-catenin pathways. Furthermore, Sirt1 inhibition attenuated the protective effect of 5-OH-Nob on ISO-induced cardiac apoptosis and fibrosis. Overall, 5-demethylnobiletin mediates the Sirt1/FOXO3a/NF-κB and Wnt/β-catenin pathways to mitigate ISO-induced myocardial fibrosis and apoptosis.

A kidney-specific fasting-mimicking diet induces podocyte reprogramming and restores renal function in glomerulopathy.

Cycles of a fasting-mimicking diet (FMD) promote regeneration and reduce damage in the pancreases, blood, guts, and nervous systems of mice, but their effect on kidney disease is unknown. In addition, a FMD has not been tested in rats. Here, we show that cycles of a newly developed low-salt FMD (LS-FMD) restored normal proteinuria and nephron structure and function in rats with puromycin-induced nephrosis compared with that in animals with renal damage that did not receive the dietary intervention. LS-FMD induced modulation of a nephrogenic gene program, resembling renal developmental processes in multiple kidney structures. LS-FMD also activated podocyte-lineage reprogramming pathways and promoted a quiescent state in mature podocytes in the rat kidney damage model. In a pilot clinical study in patients with chronic kidney disease, FMD cycles of 5 days each month for 3 months promoted renoprotection, including reduction of proteinuria and improved endothelial function, compared with that in patients who did not receive the FMD cycles. These results show that FMD cycles, which promote the reprogramming of multiple renal cell types and lead to glomerular damage reversal in rats, should be tested further for the treatment of progressive kidney diseases.

Monte Carlo damage models of different complexity levels predict similar trends in radiation induced DNA damage

Ion therapies have an increased relative biological effectiveness (RBE) compared to X-rays, but this remains poorly quantified across different radiation qualities. Mechanistic models that simulate DNA damage and repair after irradiation could be used to help better quantify RBE. However, there is large variation in model design with the simulation detail and number of parameters required to accurately predict key biological endpoints remaining unclear. This work investigated damage models with varying detail to determine how different model features impact the predicted DNA damage.&#xD;&#xD;Methods: Damage models of reducing detail were designed in TOPAS-nBio and Medras investigating the inclusion of chemistry, realistic nuclear geometries, single strand break damage, and track structure. The nucleus models were irradiated with 1 Gy of protons across a range of linear energy transfers (LETs). Damage parameters in the models with reduced levels of simulation detail were fit to proton double strand break (DSB) yield predicted by the most detailed model. Irradiation of the optimised models with a range of radiation qualities was then simulated, before undergoing repair in the Medras biological response model.&#xD;&#xD;Results: Simplified damage models optimised to proton exposures predicted similar trends in DNA damage across radiation qualities. On average across radiation qualities, the simplified models experienced an 8% variation in double strand break (DSB) yield but a larger 28% variation in chromosome aberrations. Aberration differences became more prominent at higher LETs, with model features having an increasing impact on the distribution and therefore misrepair of DSBs. However, overall trends remained similar with better agreement likely achievable through repair model optimisation. &#xD;&#xD;Conclusion: Several model simplifications could be made without compromising key damage yield predictions, although changes in damage complexity and distribution were observed. This suggests simpler, more efficient models may be sufficient for initial radiation damage comparisons, if validated against experimental data.&#xD.

Compressive resistance of thin-walled pultruded GFRP profiles: The role of delamination examined through experiments and FE simulations

Significant efforts have been made in the last decades to develop design rules and guidelines for composite structures, meeting the increasing interest in pultruded glass fibre reinforced profiles (GFRP) by the construction industry. One aspect that has been difficult to address is the crushing resistance of these profiles, with previous research indicating that the design equations are not conservative, predicting much higher resistances than those obtained in experimental tests. This paper explores the possibility that crushing resistance is governed by tensile failure in the through-thickness direction of the laminates, by Poisson effect, and proposes modifications to a previously presented material damage model to account for this in finite element (FE) simulations. Compressive experimental tests were conducted in stub-column specimens, with 5 different open-section configurations, obtained from three different producers. The test results were compared to analytical and FE simulations, confirming that the former grossly overestimate the resistance, while the latter, with the proposed damage model, compare well with experimental results.

Determination of high‐strength polymer composite reinforcement effect on the armor‐grade aluminum plates' explosion resistance—A computational perspective

AbstractThe selection of highly efficient materials is a crucial task for designing protective structures or armor against extreme explosive loadings. Due to the high strength‐to‐weight ratio of various grades of aluminum alloys and composites, they are mostly preferred for making protective structures. Investigation of their explosion resistance characteristics through experiments is very costly, dangerous, and time‐consuming. Hence, the present work deals with a cost‐effective numerical analysis on explosion resistance performance evaluation of various armor‐grade aluminum alloy plates of the same areal densities under 1–3 kilograms of trinitrotoluene explosions at a 100 mm stand‐off distance. The superior‐performance aluminum alloy plate is further reinforced with a high‐strength carbon/epoxy polymer composite to enhance its performance. The masses of the plates are maintained constant throughout the study. The Johnson‐Cook rate‐dependent material model and a progressive damage model including Hashin with Puck‐Schumann failure criteria were used to determine the realistic failures in the aluminum alloys and polymer composites, respectively. The outcomes of the study showed that the AA7075‐T6 plate has the highest deformation resistance under extreme explosion loadings. Carbon fiber‐reinforced aluminum laminate (CRALL) showed improved deformation resistance and energy absorption than those of the same mass of monolithic plate.Highlights Explosion resistance of various aluminum alloys of equal masses is compared. AA7075‐T6 provides better protection against blast compared with other alloys. To design CRALL, a carbon/epoxy composite used to reinforce the AA7075‐T6. CRALL provides 16.3% smaller peak deflection than the same mass of AA7075‐T6. CRALL improved energy absorption by 29.3% compared with same mass of AA7075‐T6.