In this paper, recent advancements in the development of a guided wave-based damage identification approach using wave damage interaction coefficients (WDICs) and deep neural networks (DNNs) are presented. These WDICs uniquely describe the complex scattering of guided waves around possible damages and depend on the properties of the damage itself. Hence, they are utilized as physics-based and highly sensitive damage features herein. It is demonstrated, that DNNs can effectively learn intricate relationships between damage characteristics and complex-shaped WDIC patterns from a compact sized training dataset. In this study, two training datasets are created by numerical finite element simulations and experimental scanning laser Doppler vibrometer measurements using a pseudo-damage approach. Therefore, the orientation and thickness of surface-bonded artificial damages are varied to generate the training data of 12 selected damage scenarios. The generalization capabilities of the fully trained DNNs allow to accurately predict WDICs even for damage scenarios unseen during training. The presented damage identification method leverages this powerful ability to characterize properties of unknown damages. Once trained, the accurate DNN predictions become available promptly and can be compared with measured WDICs from an unknown damage for selected sensor positions. The performance of both simulation-based and experiment-based structural health monitoring approaches are assessed, while also addressing current limitations and possible enhancements. For example, the great potential of incorporating the phase information of the complex-valued WDICs in the identification procedure is discussed. Hence, this study highlights the latest advancements in the development of the presented damage identification method with promising results and provides valuable insights in the application of WDICs as physics-based features for DNNs.