Critical Damage Research Articles

Thickness-dependent micro-fracture behaviors of pre-cracked aluminum plates by crystal plasticity finite element method and damage criteria

Despite the fact that fracture behaviors of pre-cracked metal plates were investigated by the crystal plasticity finite element method (CPFEM), the thickness effect on their micro-fracture behaviors is still not clear because of the different out-of-plane constraints. Here, mechanical properties and micro-fracture patterns of pre-cracked aluminum plates with different thicknesses are obtained by experiments, as well as by CPFEM combining with two damage criteria. First, finite element models are constructed based on grain morphologies of specimens achieved by electron back scattered diffraction experiments. Next, some key parameters required in CPFEM and two damage criteria are determined by fitting experimental stress–strain relationships. In particular, the factors affecting accuracy of FE predictions are clarified by CPFEM. Finally, thickness-dependent micro-fracture mechanisms of two different damage criteria in pre-cracked aluminum plates with various thicknesses and crack lengths are revealed by comparison with the experimental results and CPFEM. This investigation should be of great help for understanding thickness-dependent micro-fracture mechanisms of metal and other material plates.

Numerical study of low‐rise composite steel frame responses to blast loading using direct simulation method

AbstractThis paper investigated the blast behavior of a low‐rise composite steel structure of three stories subjected to internal and external explosions for the same explosive charge of 250 kg TNT. A comparison of three various blast scenarios is aimed at better understanding how blast waves propagate in confined risk zones and their damage effects on far and exposed elements to an explosive charge. Evaluation of the damage level and the overall response of the proposed numerical model is done by estimating the adequacy of structural members subjected to blast loading using general limits in attempting to check the structure's strength and regularity. The analysis was based on load combinations and damage criteria according to the Unified Facilities Criteria which are general design approaches suitable for civil design applications in forecasting blast loads and structural system responses. The overall behavior of this structure was simulated based on a dynamic analysis by the direct simulation approach, which was chosen for modeling blast loads using the Friedlander blast load equation, and the simpler, less expensive, more accurate, and realistic A.T.‐BLAST model to deduce the simplified blast‐wave overpressure profile. The material nonlinearity at a high strain rate using the Johnson‐Cook strength and concrete plasticity damage model is studied dynamically using ABAQUS finite element code to simulate the explicit dynamic nonlinear analysis. The overall response of the proposed numerical model was evaluated by estimating the adequacy of structural members, considering the blast load as the initial cause of failure, such as axial plastic strain, internal forces limits, maximum deformation, support rotation, demand‐capacity‐ratio (DCRshear/moment), drift index and material damage model. The position of the explosive charge played an important role in determining the rate at which the structural element begins to plastic strains, displacements, moments, or rotations beyond the limits, and then key elements should be considered in structural design against progressive collapse. Results showed that steel members exhibit early indicators of failure, such as buckling necking, shear tearing, or plastic hinges, whereas concrete slabs break up immediately due to brittleness. DCRmoment values successfully showed the columns in which the first plastic joint can occur, whereas DCRshear values signaled the onset of shear failure at connections. Besides, plastic hinges played an important role in dissipating energy and preventing total structural collapse via the Strong Column‐Weak Beam design concept, which appears repeatedly in this study. The structure is a well‐designed and ductile building capable of supporting higher loads and is considered to be repairable and intact.

Failure analysis and formability improvement of GLARE laminates in warm active hydroforming technology: Experimental and numerical approach

Warm hydroforming shows considerable promise as a forming technology for Fiber Metal Laminates (FMLs) parts due to its capacity to enhance the formability of materials. However, a detailed investigation into the failure behavior during hydroforming is still lacking. In this paper, a systematic experiment was performed to analyze the possible failure modes for GLARE in warm active hydroforming. Five main defect modes have been identified, including fiber crack, combined Al & fiber crack, wrinkle, low resin, and voids defects. The related formation mechanisms have been analyzed based on both experiments and numerical methods. Additionally, the effects of critical process parameters, including the blank holder force (BHF), liquid pressure rate (PR), and temperature (T) on failure behavior are thoroughly investigated and quantified. The use of step-loading BHF was recommended to enhance formability, which caused a nearly 36% decrease in the prepreg tensile damage criteria coefficient. Conversely, decreasing PR or increasing T significantly improved the formability of GLARE but resulted in low resin content and significant void defects. Consequently, a feasibility map that quantified the BHF and liquid pressure effects on various defects was developed, leading to optimized parameters for manufacturing a box-shaped part. This study not only explores the failure model of FMLs but also offers valuable insights for process parameter improvement and how to optimize key parameters in engineering processes.

Crack Initiation in Compacted Graphite Iron with Random Microstructure: Effect of Volume Fraction and Distribution of Particles.

Thanks to the distinctive morphology of graphite particles in its microstructure, compacted graphite iron (CGI) exhibits excellent thermal conductivity together with high strength and durability. CGI is extensively used in many applications, e.g., engine cylinder heads and brakes. The structural integrity of such metal-matrix materials is controlled by the generation and growth of microcracks. Although the effects of the volume fraction and morphology of graphite inclusions on the tensile response of CGI were investigated in recent years, their influence on crack initiation is still unknown. Experimental studies of crack initiation require a considerable amount of time and resources due to the highly complicated geometries of graphite inclusions scattered throughout the metallic matrix. Therefore, developing a 2D computational framework for CGI with a random microstructure capable of predicting the crack initiation and path is desirable. In this work, an integrated numerical model is developed for the analysis of the effects of volume fraction and nodularity on the mechanical properties of CGI as well as its damage and failure behaviours. Finite-element models of random microstructure are generated using an in-house Python script. The determination of spacings between a graphite inclusion and its four adjacent particles is performed with a plugin, written in Java and implemented in ImageJ. To analyse the orientation effect of inclusions, a statistical analysis is implemented for representative elements in this research. Further, Johnson-Cook damage criteria are used to predict crack initiation in the developed models. The numerical simulations are validated with conventional tensile-test data. The created models can support the understanding of the fracture behaviour of CGI under mechanical load, and the proposed approach can be utilised to design metal-matrix composites with optimised mechanical properties and performance.

Original Insights Into Rock Slope Damage Processes Until Collapse From Passive Seismic Monitoring

AbstractWe performed a passive seismic monitoring of the La Praz ∼14,000 m3 unstable slope (French Alps) spanning over 10 years. During the last 6 months prior to collapse, we detected a clear 24% decrease in the slope's fundamental resonance frequency, f0, caused by a reduction in overall rock mass stiffness. The combined study of f0 and slope deformation suggested the alternating importance of sudden brittle failure processes versus more ductile phases with possible sliding. Seismic monitoring revealed slope damage that remained ambiguous or undetected with ground surface deformation monitoring, and highlighted critical periods with intense damage. Only some of these critical damage periods could be related to clear external forcing factors such as intense rainfall episodes. These new insights into rock slope's structural condition at depth represent an asset for future monitoring systems. Surface deformation and passive seismic stiffness tracking combined could reveal active slopes with ongoing damage processes.

Invariant-based interpretation of anisotropic damage induced by cyclic loading

Damage of quasi-brittle materials appears as micro-cracks and is represented by a tensorial internal variable. Established anisotropic damage models are dedicated to monotonic –possibly multiaxial– loading. Additionally, the effective visualization and the interpretation of anisotropic damage are challenging. In materials with heterogeneous meso-structure, e.g., concrete, the damage field, and the corresponding induced anisotropy are heterogeneous as the orientation depends on the local mechanical state. The post-processing can be performed in the principal damage basis, but this basis can be a field that varies spatially and temporally. The present work addresses both problems: (i) the enhancement of an anisotropic damage model to tackle cyclic and alternate loading on quasi-brittle materials and (ii) the interpretation of the damage-induced anisotropy due to complex loading, such as alternate and non proportional ones. In the proposed model, the strain-based damage criterion function, more precisely the consolidation function, is constructed to be dependent on the so-called active damage. We define different invariant-based indicators of the anisotropy of both the damage and the effective elasticity tensors. These indicators are assessed for homogeneous and heterogeneous fields representing an aggregate embedded in a mortar matrix.

Acoustic Emission Monitoring of Bond Deterioration in GFRP-Reinforced Concrete Members: An Entropy-Based Approach

The primary objective of acoustic emission (AE) monitoring is to accurately detect imminent critical damage, preventing premature failure by analysing the dynamic evolution of AE parameters. This study introduces AE entropy, a distinctive parameter derived from Shannon's entropy, employed to monitor the bond degradation between glass fibre-reinforced polymer (GFRP) rebars and the concrete interface in GFRP-reinforced concrete elements. Characteristic AE parameters have been synchronously collected during flexural bond tests, and information entropy and weighted information entropy, composed of typical AE characteristic parameters based on Shannon’s information entropy theory in the time domain, have been defined. Findings indicate that, with increasing bond stress, the specimens exhibit a trend characterized by "decreasing, stabilizing, and then increasing" in both AE characteristic parameters and weighted information entropy. The information entropy value shows fluctuations during any damage associated with GFRP-concrete bond deterioration. At peak bond stress values, information entropy values experience a rapid surge, indicating significant deterioration. The evolution process of debonding between GFRP rebar and concrete, switching between a chaotic state that develops randomly and an organized state that produces in order, follows specific laws (disordered–ordered–disordered), corresponding well to AE characteristic parameters weighted information entropy. Moreover, entropy values, both individual and weighted, when correlated with bond stress and slip variations in the test specimens, distinctly outline and predict various stress transfer mechanisms between the GFRP bar and concrete. In summary, this research underscores the utility of AE entropy as a valuable tool for damage monitoring in GFRP-reinforced structures. Its ability to capture microstructural deformations positions AE entropy as a promising candidate for improving critical damage identification and preventing premature failure

Investigation on the effect of freeze–thaw cycles on damage characteristics of concrete under mixed mode I-II load conditions

In order to investigate the effect of freeze–thaw cycles on the damage characteristics of mixed mode I-II crack propagation in concrete. The three-point bending and three-point shear fracture test were carried out on specimens subjected to different freeze–thaw cycles (0, 50, 100, 150 and 200). The analytical expression of mixed mode I-II damage scale r0(I,II) and ru(I,II) was derived, and the effect of freeze–thaw cycles on damage scale was analyzed. In addition, the critical damage scale of mixed mode I-II fracture was obtained using the numerical simulation method, and the simulation results were compared with the calculation results. Finally, the accumulate energy and tension-shear failure of concrete after freeze–thaw cycles were analyzed based on acoustic emission technology.

Research on the Influence of Wheel Tread Defects on Rolling Contact Fatigue

With the rapid development of high-speed trains, local rolling contact fatigue caused by special local defect damage forms has become more prominent. This article takes circular defects as the research object, adopts the Jiang Sehitoglu multi-axis fatigue damage criterion based on the critical plane method, establishes a finite element model of wheel tread circular defects, and studies the influence of wheel tread circular defects on wheel rail rolling contact fatigue. Based on finite element analysis to obtain fatigue damage parameters, an improved PSO-BP neural network was used to establish a neural network prediction model for fatigue damage parameters, and the feasibility of the model was demonstrated. The research results show that the main influencing factors on the rolling contact fatigue life of wheel tread defects are shear stress and shear strain; The fatigue damage parameter is maximum at the edge of the wheel tread defect; As the defect distribution moves from the center to both sides, the contact stress and damage parameters gradually decrease; As the depth of the defect increases to the size of the radius, the contact stress and damage parameters first increase and then decrease; As the diameter of the defect increases, the contact stress and damage parameters increase, but the amplitude change gradually tends to stabilize with the increase of the defect diameter. The neural network prediction results indicate that all predicted samples are within a reasonable range, and this neural network model can provide a reference for predicting fatigue damage of wheel tread.

A comprehensive analysis of royal jelly protection against cypermethrin-induced toxicity in the model organism Allium cepa L., employing spectral shift and molecular docking approaches

In this study, the toxicity of the pesticide cypermethrin and the protective properties of royal jelly against this toxicity were investigated using Allium cepa L., a model organism. Toxicity was evaluated using 6 mg/L cypermethrin, while royal jelly (250 mg/L and 500 mg/L) was used in combination with cypermethrin to test the protective effect. To comprehend toxicity and protective impact, growth, genotoxicity, biochemical, comet assay and anatomical parameters were employed. Royal jelly had no harmful effects when applied alone. On the other hand, following exposure to cypermethrin, there was a reduction in weight increase, root elongation, rooting percentage, mitotic index (MI), and chlorophyll a and b. Cypermethrin elevated the frequencies of micronucleus (MN) and chromosomal aberrations (CAs), levels of proline and malondialdehyde (MDA), and the activity rates of the enzymes catalase (CAT) and superoxide dismutase (SOD). A spectral change in the DNA spectrum indicated that the interaction of cypermethrin with DNA was one of the reasons for its genotoxicity, and molecular docking investigations suggested that tubulins, histones, and topoisomerases might also interact with this pesticide. Cypermethrin also triggered some critical meristematic cell damage in the root tissue. At the same time, DNA tail results obtained from the comet assay revealed that cypermethrin caused DNA fragmentation. When royal jelly was applied together with cypermethrin, all negatively affected parameters due to the toxicity of cypermethrin were substantially restored. However, even at the maximum studied dose of 500 mg/L of royal jelly, this restoration did not reach the levels of the control group. Thus, the toxicity of cypermethrin and the protective function of royal jelly against this toxicity in A. cepa, the model organism studied, were determined by using many different approaches. Royal jelly is a reliable, well-known and easily accessible protective functional food candidate against the harmful effects of hazardous substances such as pesticides.

A new nonlocal macro-micro-scale consistent damage model for layered rock mass

Layered rock mass exhibits transverse isotropic characteristics in deformation and strength, and the strength anisotropy is difficult to achieve in traditional local action modes. Therefore, in the framework of nonlocal macro–micro-scale consistent damage (NMMD) theory, this paper constructed a micro damage criterion suitable for layered rock, where both the critical elongation and the brittleness index of material bond are defined as an elliptic function of the bond angle. Next, based on the geometric damage reflecting continuity loss of material point, which is obtained by the weighted average of bond damages around the point, an energy degradation model of a transversely isotropic stiffness matrix is established to achieve localized damage propagation of macroscopic cracks in the layered rock mass. The reliability and advantage of the NMMD model for transversely isotropic material are verified by comparison with the experimental and phase field results through a three-point bending shale beam with different bedding orientations. Finally, the splitting mechanism and bearing capacity of the Brazilian disk with different bedding directions and different inclinations of notch are explored through the established NMMD finite element model. The model is easily implemented, enabling automatic tracing of cracks and accurate prediction of load–displacement curves.

Effects of anisotropy and infill pattern on compression properties of 3D printed CFRP: mechanical analysis and elasto-plastic finite element modelling

PurposeFinite element (FE) analysis can be used for both design and verification of components. In the case of 3D-printed materials, a proper characterization of properties, accounting for anisotropy and raster angles, can help develop efficient material models. This study aims to use compression tests to characterize short carbon-reinforced PA12 made by fused filament fabrication (FFF) and to model its behaviour by the FE method.Design/methodology/approachIn this work, the authors focus on compression tests, using post-processed specimens to overcome external defects introduced by the FFF process. The material’s elastoplastic mechanical behaviour is modelled by an elastic stiffness matrix, Hill’s anisotropic yield criterion and Voce’s isotropic hardening law, considering the stacking sequence of raster angles. A FE analysis is conducted to reproduce the material’s compressive behaviour through the LS-DYNA software.FindingsThe proposed model can capture stress values at different deformation levels and peculiar aspects of deformed shapes until the onset of damage mechanisms. Deformation and damage mechanisms are strictly correlated to orientation and raster angle.Originality/valueThe paper aims to contribute to the understanding of 3D-printed material’s behaviour through compression tests on bulk 3D-printed material. The methodology proposed, enriched with an anisotropic damage criterion, could be effectively used for design and verification purposes in the field of 3D-printed components through FE analysis.

Damage and failure mechanisms of carbon fiber reinforced composite thin-walled bushings under hygrothermal-mechanical loadings

Numerous thin-walled bushings, injection-molded from AS4 short carbon fiber reinforced polyetherketone (AS4/PEK) composites, are employed in the chains of stenter heat-setting machines. These bushings rapidly deteriorate under the hygrothermal-mechanical loadings prevalent in their service conditions. This necessitates regular replacements, critically limiting machine efficiency. In this paper, considering hygrothermal-mechanical loadings, the macro–micro dual-scale damage model of composite bushings is established. The wet and thermal effects are introduced into constitutive models and damage criteria based on the macro–micro mechanics of composites and their constituents. The micro-damage and macro-destruction phenomena in the bushing are analyzed, and the related measures are proposed to delay its failure. Comparing the simulation results with the test, the macro–micro damage and failure behavior are discussed for the failed bushing. It reveals that stress concentrations near AS4 fibers initiate interfacial damage and microcracks in the PEK matrix, inciting interface debonding and matrix fragmentation, ultimately provoking composites failure. Increasing the interface thickness can delay the onset of damage. Fiber tension failure, matrix tensile, and compressive failure induce destruction at the component extremities. According to the influence of hygrothermal performance, within the glass transition temperature range of 160 °C to 240 °C, selecting composites with higher glass transition temperatures can enhance the failure strength of bushings by 19 %. Conversely, within a moisture absorption range of 0.5 % to 0.8 %, opting for materials with lower moisture absorption decreases the failure strength of bushings by 37 %. Optimal failure strength is achieved with composites having a 0.5 % moisture absorption rate and a 240 °C glass transition temperature.

Computational analysis of the failure mechanisms of a laminated composite in double-edge notch compression configuration

This manuscript presents a combined experimental–computational investigation of the compression failure response of laminated composites in double-edge notch compression (DENC) configuration. Analysis of in-situ and post-test DENC experiment results indicates the presence of multiple failure mechanisms, including ply splitting, delamination, and compression kink bands. In order to characterize the onset, growth, and interplay of the critical and subcritical damage mechanisms, a multiscale progressive damage analysis approach is implemented. A nonlocal multiscale damage model explicitly tracks the intraply failure mechanisms that lead to the formation and propagation of kink bands in the specimen. A cohesive zone model is used to track initiation and progression of ply splitting in the specimen. The splitting model was implemented using implicit finite element simulations and deployed with a pre-crack insertion technique to reduce simulation time while preserving prediction accuracy. Model parameters are calibrated based on available calibration data and measurements. The effects of split location and growth characteristics on model predictions are studied. The computational model along with a suite of experiments were employed to study the formation, growth and interactions of damage mechanisms in the composite specimens subjected to compression loading. The onset of matrix damage is not clear from the experimental images but the model predicts early onset around the onset time of splits which greatly reduce the stress concentration at the notches. Analysis of acoustic emission energy experimental data indicate that observable compression failure mechanisms are not causing nonlinearity consistently exhibited in the experiment responses. Simulation results demonstrate the capability of the multiscale modeling approach to predict critical kink bands and sub-critical matrix cracking and splitting in the DENC specimens while reducing computational cost compared to a direct numerical simulation of fibers and matrix.

Environmental Damage in Ukraine as Environmental War Crime under the Rome Statute

Abstract The Russian invasion of Ukraine has caused irreparable damage to the natural environment. Despite being a topic of wide discussion, an analysis of whether the attacks causing such damage can be tried at the International Criminal Court (ICC) as an environmental war crime (EWC) under Article 8(2)(b)(iv) of the Rome Statute remained grossly inadequate. Even after the Kakhovka Dam destruction in June 2023, the most significant incident of environmental damage since the war started, no comprehensive analysis of the incident from an EWC perspective was made. The present article fills this void and thoroughly analyses whether the dam breach can qualify as an EWC under Article 8(2)(b)(iv), the most ecocentric provision in the entire international criminal law (ICL) framework. After providing an overview of the environmental damage caused and a synopsis of the EWC, this article applies the EWC provision to the incident and discusses the prospects and the challenges of characterizing it as an EWC. This article suggests that Russia’s intentional attack on the dam can be a potential case of EWC under Article 8(2)(b)(iv) as it caused ‘widespread, long-term and severe’ environmental damage in contrast to little military advantage — which was arguably known to Russia. At the same time, however, the article identifies some challenges that the ICC Prosecutor may face in proving the case, like determining the ‘attack’ question, satisfying the ‘long-term’ damage criterion, and establishing the mental elements, particularly the ‘knowledge’ element. It also briefly discusses the broader implications of the assessment and the identified challenges. The article concludes that the challenges can be surmounted and, in any case, bringing such a charge will offer the ICC an avenue to clarify the existing uncertainties surrounding Article 8(2)(b)(iv), which will ensure legal certainty and help ensuring environmental justice through the ICL regime in future.

Impact of Root Cutting on Acer platanoides and Tilia cordata Tree Stability in Urban Parks: A Case Study in Quebec City, Canada

Trees growing in urban environments are often impacted by maintenance or construction work involving the cutting of roots. Tree protection zones have been proposed to avoid critical damage to the tree. However, despite incorporating quantitative information, they heavily rely on expert judgement that remains to be validated. In a study conducted across six parks in Quebec City, Canada, two commonly found tree species, Acer platanoides L. and Tilia cordata Mill., presumed to be different in terms of vulnerability to root damage, were subjected to a range of trenching treatments. The trees were between 23 and 40 cm diameter at breast height (DBH). A safety factor was calculated relating the turning moment the tree can withstand to the turning moment imposed by high winds likely to occur. The safety factor against uprooting was assessed for each tree before and after root trenching using a non-destructive pulling approach. The effects of tree species, distance to the trench, and their combined interaction were tested on tree stability. The relationship between tree stability and soil texture, tree characteristics, and the number of damaged roots were also tested. Safety factors were initially variable, ranging from 0.5 to 4.5. T. cordata safety factors were lower than those of A. platanoides and influenced by soil texture. Trenching treatments had no effect on the safety factor, even when two perpendicular trenches were dug at 1 m from the stem. No index of the amount of root damaged was significantly related to the safety factor. Root trenching treatments that encroached closer to the tree trunk than the recommended tree protection zones did not affect the stability of both species. Nevertheless, it is essential to recognize that other ecophysiological processes might still be influenced, and long-term monitoring is crucial. Both should be taken into account when determining these zones.

Numerical Investigation of the Effect of Deltoid Radius on Tensile Load in T-joints

In this study, T-shaped joints were designed from composites with different deltoid radius. For this purpose, carbon fiber woven fabrics were preferred as reinforcement elements. Then, tensile analyzes were performed on these composite T-joints. The effect of the deltoid radius on the maximum tensile load and damage behavior of the structure was examined. As a result of the analyses, fiber tensile-compression damage images occurring in the structure for each deltoid radius were obtained along with the load-displacement graph. The Hashin damage criterion was preferred for damage onset. Material Property Degradation (MPDG) method was used for damage progression in progressive damage analysis. By increasing the deltoid radius from 6 mm to 12 mm, the maximum contact load increased by approximately 10%, and by increasing it to 18 mm, the maximum contact load increased by approximately 20.11%. Fiber compression damage, spread over a wide area on the lower surface of the flange where it does not come into contact with the web, was determined to be the dominant damage type, and it was determined that this damage decreased with the increase of the deltoid radius. it was observed that as the deltoid radius increases, the T-jointed composite structure exhibits more rigid material behavior.

Numerical Modelling of the Influence of Tidal Stresses on Fracture Patterns on the Surface of Europa

AbstractJupiter’s satellite Europa is covered by an ice shell exhibiting many surface features, including linear structures called lineae, which in this work are treated as fractures. A three-dimensional finite-element simulator is used to numerically model fracture nucleation, growth, and interaction, assuming the ice is an isotropic, linear elastic medium. Tidal stresses are exerted upon the ice through the Jovian orbital relationship. These stresses are calculated using a closed-form model derived from first principles. The fractures grow in response to stress concentration around their tips, and a damage criterion models the weakening of the ice matrix. Three-dimensional non-planar multiple fracture growth is modelled as a function of geometric multi-modal stress intensity factors computed at the fracture tips. Fracturing is evaluated over multi-scale periods, from days to millions of years, thus capturing multiple tidal effects. Fracture behaviour is modelled across the Europan surface in one domain. The patterns are dense clusters of lineae about the stress maxima with diffuse fracturing in outlying regions. Fractures are also modelled in the vicinity of subsurface meltwater lenses, where fractures form parallel to the surface in contrast to the usual perpendicular orientation. The resultant fracture patterns are qualitatively compared against images from NASA’s Galileo mission. This work contributes to the understanding of Europan lineae by illustrating how they behave in a fracture mechanics framework, and suggests interesting results regarding lineae interaction with meltwater lenses. This work is also a proof of concept for this modelling approach, and will serve as the framework for future work.

Isobolographic Analysis of the Cytoprotective Effect of Dapsone and Cannabidiol Alone or Combination upon Oxygen-Glucose Deprivation/Reoxygenation Model in SH-SY5Y Cells.

Oxidative stress and apoptosis cell death are critical secondary damage mechanisms that lead to losing neighboring healthy tissue after cerebral ischemia. This study aims to characterize the type of interaction between dapsone (DDS) and cannabidiol (CBD) and its cytoprotective effect in an in vitro model of oxygen and glucose deprivation for 6 h followed by 24 h of reoxygenation (OGD/R), using the SH-SY5Y cell line. For the combined concentrations, an isobolographic study was designed to determine the optimal concentration-response combinations. Cell viability was evaluated by measuring the lactate dehydrogenase (LDH) release and 3-[4, 5-dimethyl-2-thiazolyl]-2, 5-diphenyl-2H-tetrazolium bromide (MTT) assays. Also, the reactive oxygen species (ROS) and reduced glutathione (GSH) levels were analyzed as oxidative stress markers. Finally, caspase-3 activity was evaluated as a marker cell death by apoptosis. The results showed a decrease in cell viability, an increase in oxidant stress, and the activity of caspase-3 by the effect of OGD/R. Meanwhile, both DDS and CBD demonstrated antioxidant, antiapoptotic, and cytoprotective effects in a concentration-response manner. The isobolographic study indicated that the concentration of 2.5 µM of DDS plus 0.05 µM of CBD presented a synergistic effect so that in treatment, cell death due to OGD/R decreased. The findings indicate that DDS-CBD combined treatment may be a helpful therapy in cerebral ischemia with reperfusion.

Compression behavior of lightweight corrugated composite Sandwich panels with smart facesheets reinforced by shape memory alloy wires: an experimental study

AbstractThis paper presents an experimental examination of the compression demeanor of lightweight corrugated core composite (CCC) sandwich panel and corrugated core smart composites (CCSC) sandwich panels subjected to quasi‐static edgewise compression loading. The existence of shape memory alloy (SMA) wires and pre‐strain percentages of SMA are the indicators studied in this article. The fabrication procedure presented and the appraisement of the mechanical properties of the CCC and CCSC sandwich panels are expressed. The core geometry of samples is trapezoid corrugated made of aluminum. The facesheets are four layers of woven glass fiber/ epoxy laminated composite. For evaluation of the efficacy of the presence of SMA wires on mechanical specifications of sandwich panels, three SMA wires with various pre‐strain percentages (0%, 3%, and 6%) are embedded in each composite facesheet. Mechanical properties of all types of CCC and CCSC sandwich panels such as maximum force, critical damage force, specific strength, absorb energy, specific toughness, Young's modulus, and specific stiffness were evaluated. Results showed that the CCC sandwich panel has higher mechanical specifications than the CCSC sandwich panels with 0% and 3% pre‐strain. Also, increasing pre‐strained SMA wires improves all mechanical parameters of CCSC sandwich panels. CCSC sandwich panel with 6% pre‐strain has the highest compression properties than other sandwich panels. Maximum Force, Critical Damage Force, Specific Strength, Absorbed Energy, Specific Toughness, Young's Modulus, and Specific Stiffness of CCSC sandwich panel with 6% pre‐strain are 14.73 kN, 13.6 kN, 9.55 MPa/g, 26.61 kJ, 0.346 MJ/m3g, 4395 MPa and 0.61 kN/mm g, respectively.Highlights Lightweight CCC sandwich panel and CCSC sandwich panel manufactured. Compression behavior of CCC sandwich panel and CCSC sandwich panel evaluated. Pre‐strained SMA wires improves energy absorption of CCSC sandwich panels. Higher specific toughness was obtained with 6% pre‐strain SMA. Presence of SMA wires with no pre‐strain cannot improve the specific strength.