The damage behavior and explosion resistance of air-backed steel-concrete-steel (SCS) composite panels subjected to underwater contact explosions were investigated experimentally and numerically. Firstly, the underwater explosion experiments of the SCS panels were conducted using the novel test setup, and the final damage morphology and residual deflection of these panels were obtained. Secondly, the corresponding finite element model was established in LS-DYNA and validated against the test results, based on the refined numerical modelling, the damage process of the SCS composite panel under 200 g underwater contact explosion was reproduced. After that, the damage mechanism of the SCS panels was revealed through the analysis of internal energy absorption and stress wave propagation inside the SCS panels. Subsequently, the damage behavior of the SCS panels when subjected to underwater and air contact explosions was compared. Finally, a series of parametric analysis were performed to explore the effects of the material strength and structural form on the explosion resistance of SCS panels. Both the experimental and numerical results indicate that the SCS panels suffered global damage. The core concrete absorbed more than 80 % of the explosion energy and the restraint of the steel plates effectively reduced the spalling damage of the core concrete. The SCS composite panel makes full use of the advantages of concrete and steel panels, resulting in superior underwater explosion resistance.