Comparative evaluations were made of the deposits on three low-water content hydrogel contact lens polymers, tetrafilcon A (Aquaflex), crofilcon (CSI), and tefilcon (Cibasoft) by scanning electron microscopy (SEM) and modified Lowry protein assay techniques. Ten patients wore each of the three lenses for a period of 1 week on a daily wear basis. Surfactant cleaning and chemical disinfection of lenses was carried out but no enzymatic cleaning was performed. No significant difference was found, by either technique, in the amount of deposit on the three lens materials. No direct correlation was found between the measurements by each technique. It is concluded that, quantitatively, the crofilcon (CSI) material is not more deposit resistant than are other similar low-water content, nonionic hydrogel lens polymers. This finding supports the hypothesis that water content and/or surface chemistry of the lens materials determines their deposit characteristics.