This study originally presents for the first time an idea that combines chemical and physical sorption for water desalination applications. It shows working principles of a hybrid salt hydrate/adsorption in a single water desalination system and presents a mathematical model for its performance. Three beds system has been considered employing high and low pressures evaporators. Different operating conditions like driving, cooling temperatures and cycle time of the system have been studied. The innovated hybrid system has two effective advantages over the known two beds adsorption desalination cooling system with a single evaporator. The first advantage is the proposed system has higher performance in terms of daily water production, cooling power and coefficient of performance by 56%, 55%, and 25% respectively. It also could be operated efficiently with a relatively low driving temperature (55 °C–65 °C) presenting a daily pure water of 8–9 m3/day·tonads where solar and/or waste energy can be used.