Daily Life Functioning Research Articles

Don’t be late! Timely identification of cognitive impairment in people with multiple sclerosis: a study protocol

BackgroundCognitive impairment occurs in up to 65% of people with multiple sclerosis (PwMS), negatively affecting daily functioning and health-related quality of life. In general, neuropsychological testing is not part of standard MS-care due to insufficient time and trained personnel. Consequently, a baseline assessment of cognitive functioning is often lacking, hampering early identification of cognitive decline and change within a person over time. To assess cognitive functioning in PwMS in a time-efficient manner, a BICAMS-based self-explanatory digital screening tool called the Multiple Screener©, has recently been developed. The aim of the current study is to validate the Multiple Screener© in a representative sample of PwMS in the Netherlands. Additionally, we aim to investigate how cognitive functioning is related to psychological factors, and both work and societal participation.MethodsIn this cross-sectional multicentre study, 750 PwMS (aged 18–67 years) are included. To obtain a representative sample, PwMS are recruited via 12 hospitals across the Netherlands. They undergo assessment with the Minimal Assessment of Cognitive Functioning in MS (MACFIMS; reference-standard) and the Multiple Screener©. Sensitivity, specificity, and predictive values for identifying (mild) cognitive impairment are determined in a subset of 300 participants. In a second step, the identified cut-off values are tested in an independent subset of at least 150 PwMS. Moreover, test–retest reliability for the Multiple Screener© is determined in 30 PwMS. Information on psychological and work-related factors is assessed with questionnaires.DiscussionValidating the Multiple Screener© in PwMS and investigating cognition and its determinants will further facilitate early identification and adequate monitoring of cognitive decline in PwMS.

The Extent and Nature of Functional Limitations According to the Health Assessment Questionnaire Disability Index in Patients with Rheumatoid Arthritis and Severe Functional Disability.

For a subgroup of people with rheumatoid arthritis (RA) and severe disability, insight into their limitations is crucial for adequate treatment. To describe the extent and nature of functional limitations in people with RA and severe disability and to explore the associations of the extent of the functional limitations with patient characteristics, disease characteristics, and outcome measures. Baseline data of 215 participants in an RCT on the (cost-)effectiveness of longstanding physiotherapy were used. Functional limitations were assessed with the Health Assessment Questionnaire Disability Index (HAQ-DI). The total HAQ-DI including eight domain scores were calculated. Associations between high HAQ-DI scores (≥2, yes/no) and other variables were examined using the Student's t-test or Chi-squared test where appropriate. The participants (90% women, age 58.8 ± 12.8 years) had a mean HAQ-DI score of 1.7 ± 0.5. The majority (56%) showed a moderate-to-severe disability in all domains. Higher HAQ-DI scores seemed to be associated with advanced age, longer disease duration, unemployment, joint replacements, and outcomes for daily functioning and physical quality of life, but not with measures of disease activity. Our findings indicate that a comprehensive assessment of all areas of daily activities in this subgroup is necessary in order to provide appropriate (non-)pharmacological care.

Boundaries and classification: the cultural logic of treating foreign medicine

From the 16th to the 19th centuries, Western medicine emerged in China and was considered dangerous by Chinese residents. Relatedly, Chinese medical practitioners have attempted to use knowledge based on traditional Chinese medicine to explain the principles of Western medicine. From the 19th to 20th centuries, traditional Chinese medicine (TCM) was introduced to the United States, and American residents also described it as dangerous; they believed that TCM could only be accepted after scientific verification and explanation. This article uses the method of historical anthropology to explain these phenomena using boundaries as an analytical concept. This article finds that when foreign medicine crosses borders, it causes the disorganization of local classification systems. When a local classification system cannot provide a suitable location for foreign medicine, such medicine is easily regarded as dangerous by residents. The key to solving this problem is to use local classification systems to reinterpret foreign medicine. Reinterpreted by these local classification systems, foreign medicine can gain legitimacy within local societies. Based on this, the current article attempts to illustrate not only that science is a classification method but also that the boundary between science and nonscience is cultural in a sense, thereby undertaking corresponding cultural functions in daily life.

Unveiling the Interplay Between Depressive Symptoms' Alleviation and Quality of Life Improvement in Major Depressive Disorder: A Network Analysis Based on Longitudinal Data.

Understanding the dynamic relationship between depressive symptoms and quality of life (QOL) is essential in improving long-term outcomes for patients with Major Depressive Disorder (MDD). While previous studies often relied on cross-sectional data, there is a pressing need for stronger evidence based on longitudinal data to better inform the development of effective clinical interventions. By focusing on key depressive symptoms, such interventions have the potential to ultimately enhance QOL in individuals with MDD. This multi-center prospective study, conducted between 2016 and 2020, enrolled outpatients and inpatients diagnosed with MDD across twelve psychiatric hospitals in China. Longitudinal data on Patient Health Questionnaire - 9 (PHQ-9) and Quality of Life Enjoyment and Satisfaction Questionnaire-Short Form (Q-LES-Q-SF) was analyzed using an Extended Bayesian Information Criterion (EBIC) graphical least absolute shrinkage and selection operator (gLASSO) network model to explore the connections between depressive symptom changes and QOL changes. Flow network was applied to investigate relationships between individual symptom changes and overall QOL score change, as well as daily functional independence. This study included 818 participants with complete data after 8-week antidepressant treatment. Apart from the overlapping items from PHQ-9 and Q-LES-Q-SF, the three edges between "mood" (delta-QLES2) and "anhedonia" (delta-DEP1), between "physical health" (delta-QLES1) and "sleep problems" (delta-DEP3), and between "physical health" (delta-QLES1) and "sad mood" (delta-DEP2) were the most strong bridges between the cluster of depressive symptoms alleviation and the cluster of QOL change. "Anhedonia" (delta-DEP1), "sad mood" (delta-DEP2) and "loss of energy" (delta-DEP4) had the highest bridge strength between the alleviations of depressive symptoms and the total score change of Q-LES-Q-SF. Anhedonia had the greatest connection with participants' satisfaction with function in daily life. This study highlighted the potential for developing highly effective interventions by targeting on central symptoms, thereby to ultimately improve QOL for patients with MDD.

Stress‐related fluctuations in personality functioning in daily life: Pilot data from an ambulatory monitoring study in outpatients diagnosed with borderline personality disorder

AbstractThis pilot study aimed to test a comprehensive experience sampling method (ESM) protocol for investigating the relationship between stress and personality functioning (PF) in the daily lives of outpatients diagnosed with borderline personality disorder (BPD). Participants (N = 22) responded to a 32‐item ESM questionnaire 10 times a day for 1 week while wearing two stress detection devices. Results showed that the protocol was feasible. There was a high level of compliance (i.e. average of 85%), and no serious adverse events. The main indices, that is, Stress and PF, demonstrated acceptable to excellent internal consistency and provisional evidence for their validity. We found that 64% of the variability in PF was due to within‐subject differences. Mixed modelling showed that the momentary changes in stress (p < .001) and body position (i.e. active vs passive; p < .001) explained an estimated 46% of this within‐subject variance. We found no significant within‐subject effects when we used parameters of autonomic nervous system (ANS)–activity as predictors. Data loss during recording and artefact detection of electrophysiological data were substantial but not related to momentary changes in PF. The preliminary findings suggest that PF is a volatile aspect of personality pathology and that there is a strong, concurrent relationship between stress and PF in daily life. This pilot study constitutes the first demonstration of PF fluctuations within a clinical sample and initiates an examination of their association with ANS activity.

Creasing and folding of paper-based sandwich material–Phenomena and modelling

Creasing and folding are fundamental steps in many manufacturing processes of multi-material paperboard packaging. The complex structure of these materials, which comprise layers of cellulose fibres, aluminium, and polyethylene, coupled with the growing complexity of packaging designs, make these process operations essential to ensure the required structural integrity for packaging as well as their functionality in daily life. This paper introduces an approach for modelling damage in paper-based sandwich materials by integrating fibre-based and cohesive numerical modelling techniques. The results prove the effectiveness of the proposed methodology, opening new possibilities for process design and optimization in packaging manufacturing.

Kinematic Analysis of Pelvic and Lower Limb Joints during Stand-to-sit Movement in Individuals with Chronic Low Back Pain: A cross-sectional study.

It is crucial to investigate the daily functions commonly utilized by individuals with low back pain (LBP) due to their implications for recurrence and chronicity. Stand-to-sit (StTS) task is one of the more repetitive functions in human daily life. This study aims to evaluate pelvic and lower limb joint kinematics during the StTS task in individuals with Non-Specific Chronic Low Back Pain (NSCLBP) compared to a healthy control group. Pelvic and lower limb joint kinematic data in all three planes were recorded from 20 individuals with LBP and 20 healthy individuals using a Qualisys motion capture system during the StTS task. A Functional Data Analysis statistical approach was employed to compare the kinematic data between the two groups. In the initial phase of the movement, we observed a greater anterior pelvic tilt (P=0.028) and an altered pelvic frontal plane motion pattern (P=0.029) in the LBP compared to the healthy group. The only significant differences between the lower limb joint kinematics of the two groups were a less hip external rotation position (P=0.025) and a more knee adduction pattern (P=0.002) on the right side in the LBP subjects compared to the healthy group. Considering a few differences noted between the two groups across various joints and planes evaluated, it appears that the kinematic pattern of the lower limbs does not significantly differ between the NSCLBP and healthy groups during the StTS task in most comparisons. However, distinct kinematic patterns have been observed in the pelvic region, particularly in the sagittal and frontal planes, between the two groups.

How significant is the effect of the type of work on irritable bowel syndrome symptoms over time in a sample of the Saudi community? A cross-sectional study

Objective: This study aimed to evaluate the stress produced by occupation in irritable bowel syndrome (IBS) patients and to assess the relationship between the type of work and IBS symptoms and the impact it has on an employed population in Riyadh city, Saudi Arabia. Methods: This was a cross-sectional study adopted among the employed population in Riyadh city, Saudi Arabia. A questionnaire was distributed online via social media applications (WhatsApp, Twitter, and Facebook) with the purpose of recruiting participants from the employed population in Riyadh city. Results: The study found that IBS had various impacts on participants\' daily lives. Around 8.5% reported impairment in their ability to work, while 16.4% reported moderate impairment in their ability to perform household chores. The study also revealed that participants experienced negative impacts related to their bowel problems. Almost 33.6% reported being bothered by the amount of time spent on the toilet. The findings also revealed that there was a 0.130 unit reduction in productivity. Similarly, a 0.065 unit reduction in the ability to do regular daily activities, other than working at job being result of the increased IBS Symptoms by one unit. Conclusion: A considerable number of participants in the study disclosed missing work due to their IBS symptoms, indicating challenges in balancing their condition with regular work attendance. Moreover, participants reported substantial impairment in household tasks, social activities, and forming close relationships, underscoring the significant impact of IBS on daily functioning and overall quality of life.

Specialized Allied Health Care for Parkinson's Disease: State of the Art and Future Directions.

People with Parkinson's disease (PD) experience a range of progressive motor and non-motor symptoms, that negatively affect their daily functioning, social participation and quality of life. Allied health therapies have emerged as an effective treatment approach-complementary to pharmacological and neurosurgical treatments-which reduces the impact of PD in daily life. In this article, we propose criteria for what constitutes specialized allied health care for PD, and we review allied health research in PD in terms of meeting these criteria and its outcomes for monodisciplinary approaches as well as multi- or interdisciplinary allied health interventions. We focus on the three most studied allied health disciplines in PD: physical therapy, occupational therapy and speech-language therapy. Overall, the available evidence underscores the importance and potential benefits of specialized allied health care for people with PD. Our proposed criteria and recommendations for future research might help in further delineating specialized allied health care.

Daily life participation in PTSD: pilot study on patterns and correlators.

Participation in daily life activities with both the personal and community meaning is an important component of health and well-being. Even though there are mounting reports on the challenges in various aspects of daily-life functioning among individuals with post-traumatic stress disorder (PTSD), to date little research has been conducted on their comprehensive patterns of participation. The study aimed to describe objective and subjective participation dimensions in PTSD compared to healthy controls and investigate the association between personal and environmental factors and participation. Sixty-one individuals were enrolled in two groups: PTSD (N=31; age: M=34.3; women:77.4%) and healthy controls matched by age and gender. The PTSD group completed standard assessments for symptom severity, general cognition, executive function (EF), sensory processing, self-efficacy, functional capacity, and environmental properties. Both groups completed a participation questionnaire. Individuals with PTSD participated with low intensity and diversity, more occupations were abandoned (-4.73<t<5.73, p<0.05), and less meaning was found in the included occupations. Participation objective dimensions were associated with self-reported EF (-0.47<r<-0.42, p<0.05), sensory modulation profile (2.51<t<2.81, p<0.05), and environmental properties (-0.44<r<0.5, p<0.05), but not with PTSD symptom severity, and objective measures of cognition and functional capacity. No correlators were identified for subjective participation dimensions. The study demonstrates profound restrictions in participation in PTSD raising serious concerns. There are unique patterns of association between objective participation dimensions, subjective cognitive indices, sensory modulation, and environmental factors, suggesting a need for PTSD feature-specific intervention approaches to advance the participation of those with PTSD as a means of promoting health and well-being.

Effects of 1 ㎐ Low-Frequency Repetitive Transcranial Magnetic Stimulation Combined with Upper Limb Robotic Therapy on Upper Limb Function and Activities of Daily Living in Stroke Patients

Effects of 1 ㎐ Low-Frequency Repetitive Transcranial Magnetic Stimulation Combined with Upper Limb Robotic Therapy on Upper Limb Function and Activities of Daily Living in Stroke Patients

The Effect of Spaced Retrieval Training Using Theratainment on the Cognitive Function and Activities of Daily Living of Patients with Mild Cognitive Impairment After Stroke

The Effect of Spaced Retrieval Training Using Theratainment on the Cognitive Function and Activities of Daily Living of Patients with Mild Cognitive Impairment After Stroke

The Contribution of Mental Health Cadres to Improving Client and Family Psychosocial Health

Mental disorders are the conditions of poor functioning of physiological and mental processes that impact changes in thoughts, feelings, and behaviour that interfere with the function of daily life. The method of service was carried out by counselling families and patients with physical illnesses, then continued with mental health gymnastics. Based on the results of this service knowledge before and after education were obtained, there was an increase in knowledge after being given health education, in which the pretest given to 32 elderly people showed that 12 elderly people got a score of 100. In comparison, the post-test results showed that 18 elderly people scored 100. The conclusion of implementing this community service is the importance of mental health cadres' role in mobilising healthy families and the risk of psychosocial problems and mental disorders to attend counselling so that the family's health status has improved. Cadres also play a role in monitoring clients with psychosocial problems and mental disorders.

Pain reduction as the main parameter for monitoring improvement in Health-Related Quality of Life (HRQoL) following endovascular treatment of Pelvic Congestion Syndrome (PCS)

The purpose of this study was to evaluate pain reduction as the main parameter for monitoring improvements in Health-Related Quality of Life (HRQoL) in a female patient following endovascular treatment of Pelvic Congestion Syndrome (PCS).A 38-year-old female patient with chronic intermittent, “dragging” abdominal pain, lasting more than two years, mainly in the lower abdomen, radiating to the sacral region, underwent SARS CoV-2 infection in October 2021, and COVID-19, which lasted 10 days. Eight months later, complaints of pain in the lower abdominal area, during the mentrual cycle, during prolonged standing, after sports activities and during and after intercourse, increased. The patient was compelled to begin diagnosis of these complaints due to the severe pain and concerns about whether she had contracted cancer of the cervix uteri. She was diagnosed on transvaginal ultrasound-Doppler and Angio-MR of the pelvic vessels with PCS. Treatment was undertaken at the Department of Vascular Surgery and Endovascular Interventions, St. John Paul II Hospital, Krakow, Poland. Intraoperatively, after confirmation through selective angiography, of previously diagnosed insufficiency of the left ovarian vein (LOV) and of the parametrial veins (PMV), the selective obliteration was performed with an adhesive dedicated to endovascular closure of veins and vascular malformations (Glubran2). The range of pain intensity, according to theVisual Analogue Scale (VAS), in Exam. 1 (before surgery), was in the premenstrual period (BM) 7.0 points, which increased during menstruation (DM) or after intense activity (AIA) to 8.0 points, and occasionally during and after intercourse even to 9.0 points. These values were very high, indicating that pain significantly affected the patient's quality of life. The extent of pain severity decreased significantly in Study 2 (two months after surgery) and Study 3 (four months after surgery) and was 2.0 points in the premenstrual period (BM), which increased only slightly during menstruation (DM) or after intense activity (AIA) to 3.0 points, and decreased again to 2.0 points during and after intercourse. The patient reported that the procedure significantly and positively affected her functioning in daily life, especially in caring for a young child, which is evidence of the achievement of HRQoL improvement.Endovascular treatment for Pelvic Congestion Syndrome (PCS) was effective in reducing pain and improving the Health-Related Quality of Life (HRQoL) of a patient with PCS.

Effectiveness of Proprioceptive Body Vibration Rehabilitation on Motor Function and Activities of Daily Living in Stroke Patients with Impaired Sensory Function.

Stroke patients experience impaired sensory and motor functions, which impact their activities of daily living (ADL). The current study was designed to determine the best neurorehabilitation method to improve clinical outcomes, including the trunk-impairment scale (TIS), Berg balance scale (BBS), Fugl-Meyer assessment (FMA), and modified Barthel index (MBI), in stroke patients with impaired sensory function. Forty-four stroke survivors consistently underwent proprioceptive body vibration rehabilitation training (PBVT) or conventional physical therapy (CPT) for 30 min/session, 5 days a week for 8 weeks. Four clinical outcome variables-the FMA, TIS, BBS, and MBI-were examined pre- and post-intervention. We observed significant differences in the FMA, BBS, and MBI scores between the PBVT and CPT groups. PBVT and CPT showed significant improvements in FMA, BBS, TIS, and MBI scores. However, PVBT elicited more favorable results than CPT in patients with stroke and impaired sensory function. Collectively, this study provides the first clinical evidence of optimal neurorehabilitation in stroke patients with impaired sensory function.

FEASIBILITY OF CONTINUOUS PASSIVE MONITORING OF DAILY FUNCTION AND SYMPTOMS IN OLDER ADULTS WITH MULTIPLE MYELOMA

Abstract The impact of cancer and cancer treatment on older adults’ day-to-day health and functioning remains poorly characterized. Therefore, we evaluated the feasibility of using home-based, continuous passive monitoring of daily life functioning plus symptom surveys in older adults with multiple myeloma (MM). We assessed accrual, uptake of passive monitoring, retention, survey completion, and data completeness. Passive monitoring included infrared motion sensors (activity), door contact sensors (time out-of-home), watch (activity/sleep), bed mat (sleep), biometric scale (weight), electronic pillbox (medication-taking habits), and computer-use software (computer habits). A weekly online survey assessed health events (i.e., falls, hospitalization/ED visits, pain) and treatment-related symptoms (PRO-CTCAE). We enrolled 20 patients with MM of 55 referred (36% accrual) with a median age of 71 years (35% female); 8 patients enrolled with a care partner. Half of patients agreed to passive monitoring and weekly surveys; half completed surveys only. Refusal of passive monitoring was primarily due to concerns about privacy/intrusiveness. Retention over 17 months was 85% (3 dropouts from the survey-only group). Survey completion was 82% (missing reasons included “poor health” and “too busy”) with a median completion time of 4.6 minutes. Data completeness for passive monitoring ranged from 66% for watch-based sleep (n=9 patients) to 93% for home-based activity (n=14 homes). In sum, passive monitoring of daily life functioning plus symptom surveys is feasible among older adults with MM. Future research will integrate daily functioning with symptom data to examine longitudinal variations in health and develop digital biomarkers to inform optimal timing of future interventional studies.

Effectiveness of social management training on executive functions in males with Klinefelter syndrome (47, XXY)

Men with an extra X chromosome are at risk for social difficulties in which executive functions are known to play an important role. The aim of this study was to examine the potential efficacy of a novel neurocognitive-behavioral treatment program tailored to the specific vulnerabilities of Klinefelter syndrome (47, XXY). Social Management Training (SMT) aimed to increase the ability of individuals to regulate their thoughts, emotions and behaviors in ways that are socially adaptive. 16 Adolescents and men with Klinefelter Syndrome participated in SMT. This novel group treatment program consists of 10 sessions and includes psychoeducation, cognitive-behavioral skills training, home-assignments, and relaxation exercises. There were pre- and posttest cognitive assessments (five months apart) of executive functioning including sustained attention, inhibition, cognitive flexibility and working memory, as well as self-evaluation of executive functioning in daily life. Significant pre- to posttest improvements in inhibitory control (performance test) and metacognition skills (self-report) were found, with effects sizes of 1.3 and 0.5, respectively. No effects of intervention were found on sustained attention, cognitive flexibility and working memory. These findings suggest that SMT, with a key focus on executive dysfunction and tailored to the behavioral and cognitive profile of males with Klinefelter syndrome, may be a promising and potentially efficacious treatment approach for improving self-control and social adaptation, although larger and randomized controlled studies are warranted.

Edukasi Sit to stand exercise dengan Walker pada Pasien Stroke di Posyandu Lansia Keprabon

Stroke is a blood vessel disease that is mostly caused by high blood pressure, resulting in rupture of blood vessels and bleeding in certain areas. This disease can be interpreted as a pathological condition that affects the entire body, for example paralysis, impaired cognitive function, difficulty speaking, emotional difficulties, pain and problems in daily life which cause various activity limitations for the sufferer. This of course requires appropriate medical rehabilitation that is appropriate to the condition of stroke sufferers. Medical rehabilitation is provided with the aim of optimizing and even returning the patient's body functions to normal. This rehabilitation has three main focuses, namely: medical, social and vocational rehabilitation. Stroke sufferers who are still recovering and do not receive a good rehabilitation program are certainly less able to carry out activities independently, such as from sitting to standing with balance and without the help of other people, as is found at the elderly posyandu in Keprabon Village. In the rehabilitation process, of course, family support is very necessary in helping to get optimal results. So this activity aims to provide education about sit to stand exercise to stroke sufferers and the families of sufferers at the elderly posyandu in Keprabon Village. With this physiotherapy training program activity, it is hoped that it will provide good benefits for sufferers and their families because it aims to increase the independence of stroke sufferers who are in the posyandu in Keprabon Village by increasing functional activities, especially balance in carrying out movements from sitting to standing by routinely doing sit to stand exercises. proper exercise.

Neuropsychological functioning during chemotherapy with temozolomide in high-grade glioma patients: a retrospective single centre study.

starting from a lack of precise and coherent data in literature, aim of this work is to retrospectively study the influence of chemotherapy with Temozolomide (TMZ) on a wide series of neuropsychological functions in a population of adult high-grade glioma patients. an extensive neuropsychological battery was administered pre-operatively (T0) and after 6 (T1) and 12 months (T2) from surgery. After full recovery from surgery, TMZ was delivered concomitant to radiotherapy and, subsequently, adjuvantly for 5-day cycles per month. Parametric and non-parametric analyses were conducted to verify the influence of several aspects of chemotherapy on the adjusted scores of each cognitive test at the two post-operative follow-ups. Sixty-one patients were included at T0; patients with a lower adjuvant TMZ dosage reported a better performance at the visual attention test at T1, and at the deductive reasoning test at T2. Undergoing more than 8 cycles of adjuvant therapy was slightly associated with a better performance at the long-term verbal memory tasks at T2. No other associations were found with the other cognitive tests and autonomy scales administered. TMZ proved to be a secure treatment with no negative side effects on cognition and on level of daily autonomy, even at the highest dosage used. This is a positive finding which enables clinicians to reassure patients about the absence of significant negative effects of TMZ on their daily life functioning. In this view, eventual cognitive changes during treatment might not be attributed to chemotherapy but to other events such as tumour relapse.

Long-term aging trajectories of the accumulation of disease burden as predictors of daily affect dynamics and stressor reactivity.

Multiple-timescale studies provide new opportunities to examine how developmental processes that evolve at different cadences are intertwined. Developmental theories of emotion regulation suggest that the long-term, slowly evolving age-related accumulation of disease burden should shape short-term, faster evolving (daily) affective experiences. To empirically examine this proposition, we combined data from 123 old adults (65-69 years, 47% women) and 32 very old adults (85-88 years, 59% women) who provided 20 + year within-person longitudinal data on physician-rated morbidity and subsequently also completed repeated daily-life assessments of stress and affect six times a day over 7 consecutive days as they were going about their daily-life routines. Results from models that simultaneously articulate growth and intraindividual variability processes (in a dynamic structural equation modeling framework) revealed that individual differences in long-term aging trajectories of the accumulation of disease burden were indeed predictive of differences in three facets of affective dynamics that manifest in everyday life. In particular-over and above mean levels of disease burden-older adults whose disease burden had increased more over the past 20 years had higher base level of negative affect in their daily lives, more emotional reactivity to the experience of daily stressors, and more moment-to-moment fluctuations in negative affect that was unrelated to stressors (affective systemic noise). We highlight that developmental processes evolving over vastly different timescales are intertwined, and speculate how new knowledge about those relations can inform developmental theories of emotion regulation and daily-life functioning. (PsycInfo Database Record (c) 2023 APA, all rights reserved).