In Accra and Greater Lomé, research into the harmful effects of food transitions focuses scarcely on the levels of knowledge and good practices (LKGP) of vegetable consumers. However, these foods play a key role in the nutritional, health, socio-economic and ecological sustainability of cities. This research aims to assess the health, nutritional, ecological and socio-economic sustainability of LKGP linked to vegetable consumption in these conurbations. A quantified multi-criteria evaluation approach was adopted. The respondents (394), selected via judgmental sampling, were equally distributed between the two cities. Data were collected using a Food Frequency Questionnaire administered by Kobocollect. The overall average rate of good vegetable consumption knowledge and practices in Accra and Greater Lomé is low (37.43%). This result stems from the low LKGP for daily vegetable consumption (24.62%), their inclusion in the main daily meals (33.50%) and consideration of their nutritional composition (30.86%). The target population is unaware of the health, nutritional and ecological drawbacks of poorly preserved vegetables (66.93%) and adopts inappropriate waste management practices when handling them (65.91%). The average proportions of access to vegetable procurement technology (47.08%) and sustainable food education (11.29%) were also low. The research results, unfavorable to the achievement of the SDGs in Accra and Greater Lomé, call for an inclusive, integrated and continuous sustainable food education program.