Daily Activities Of Patients Research Articles

Adverse dermatoneurological events and impacts on daily activities of patients with gastrointestinal neoplasms undergoing chemotherapy

RESUMO Objetivo: associar a presença e a graduação de eventos dermatoneurológicos adversos (neuropatia periférica e síndrome mão-pé) e as interferências nas atividades da vida diária de pacientes com neoplasias gastrointestinais em tratamento antineoplásico sistêmico. Método: trata-se de um estudo longitudinal, prospectivo, com a utilização de instrumentos de avaliação da síndrome mão-pé e da neuropatia periférica. Resultados: foram 36 pacientes: 66,7% com diagnóstico de câncer de cólon e 83,2% em terapia combinada. A partir do ciclo 5, todos apresentaram a síndrome mão-pé, com maioria de grau 1, não relacionada com a interferência nas atividades da vida diária. Em relação à neuropatia periférica, houve a correlação de intensidade moderada a forte desde o ciclo 1 de tratamento. Conclusão: a neuropatia periférica afeta negativamente as atividades da vida diária. O acompanhamento dos eventos dermatoneurológicos pelo enfermeiro oncológico contribui para a prática clínica da enfermagem e subsidia o desenvolvimento da prática avançada no país.

Total knee replacement in knee arthritis with fixed flexion deformity

Fixed flexion deformity of knee secondary to osteoarthritis occurs mainly due to posterior soft tissue tethering and/or contracture especially posterior capsule rather than bony changes. A flexion deformity of the knee leads to functional, biomechanical and gait impairments that interferes with the normal daily activities of patients and decrease their satisfaction after TKR. Correction of FFD is mandatory during TKR replacement to optimize postoperative results. The intraoperative correction steps differ among knee surgeons and no consensus is adopted regarding the ideal method. So, for good correction a sequential stepwise approach should be adopted which mainly concentrates on soft tissues rather than bone cuts.

Risk Factors for Dementia

Dementia is a disease or group of illnesses caused by damage to brain cells. Thus, a person's mental capacities are reduced, and many skills such as memory, language, problem-solving, and thinking are affected emotionally, as well as problems with normal communication, behavior, and normal functioning. The severity of the condition ranges from mild symptoms to severe illnesses that can interfere with a patient's daily activities. The incidence of dementia is rapidly increasing worldwide, especially among the elderly. Due to the rapidly aging population, the number of people living with this disease is expected to triple over the next 30 years, leading to an increase in the socioeconomic burden associated with dementia. In 2003, dementia was the fifth and eighth leading cause of death for women and men over the age of 65 in the United States, respectively.

Assessment of Hearing and Vestibular Functions in a Post-COVID-19 Patient: A Clinical Case Study

SARS-CoV-2 infection may cause such complications as post-COVID-19 syndrome, which includes chronic fatigue, myalgia, arthralgia, as well as a variety of neurological manifestations, e.g., neuropathy of small fibers, hearing and vestibular dysfunction, and cognitive impairment. This clinical case describes a 41-year-old patient suffering from post-COVID-19 syndrome and chronic fatigue syndrome. A detailed examination was performed, including an in-depth study of peripheral and central hearing and vestibular functions, as well as small nerve fibers length and density in the skin and cornea of the eye. Contrary to expectations, no peripheral nervous system dysfunction was detected, despite the presence of dizziness and gait instability in the patient. Hearing tests (gap detection test and dichotic test) showed central auditory processing disorders. The evaluated lesion in the processing of temporal and verbal auditory information can be a significant factor contributing to additional overload of the neural activity and leading to chronic fatigue when performing daily activities in patients with CFS and post-COVID-19 complications.

Difficulties in Performing Daily Activities in Patients with Dry Eye before and after Treatment.

This research consists of a cross-sectional study of 121 patients, with a mean age of 70 ± 9 years, diagnosed with DED. All patients were treated in the University Clinic for Ophthalmology in "St. Spiridon" Emergency Hospital, Iasi. For all patients, we evaluated visual acuity on the Snellen chart, tear breakup time (TBUT), Schirmer I test scores, and contrast sensitivity. For this study, we used the Visual Functioning Questionnaire-25 (VFQ-25) version 2000, modified and adapted for this research (19 items). Prior to treatment, patients had very high difficulty reading a text in a newspaper or on TV, reading prices on products in shops, or recognizing people they already met. Performing manual work or favorite activities was also very difficult. Post-treatment visual challenges improved in the majority of cases, regardless of the treatment method used. We found that symptomatic dry eye disease was associated with reduced ability in performing several important vision-related daily tasks and has a significant impact on life quality and visual performance.

Interventional Imaging Techniques as Alternative to Surgery of the Foot and Ankle.

A variety of foot and ankle pathologies can impair patient's daily activities, ultimately requiring surgical management. However, with improvements in image-guided intervention, the joints, soft tissues, and osseous structures may be accessible using various percutaneous techniques as a potential alternative therapeutic tool, avoiding the need for surgery with its associated risks and morbidity. This article discusses the potential range of image-guided interventional treatments. Injections, aspiration, biopsies, cryoablation, and radiofrequency ablation are described. Newer novel treatments are also covered. Finally, the common pathologies of Morton's neuroma, Achilles tendinopathy, and plantar fasciitis are addressed.

Automated documentation of almost identical movements in the context of dementia diagnostics

When monitoring the health state of people with neurological diseases, it is crucial to detect disease progression and disease-related changes as soon as possible. Such changes can be detected in the performance of everyday activities like eating, drinking, nose blowing, reading, looking at photos, knitting, telephoning, or brushing hair. In order to supervise such everyday activities, this work proposes an approach employing smartwatches in combination with a Recurrent neural network. A smartwatch offers the possibility of integrating sensor technology into a patient’s daily routines in a unobtrusive way. We have developed a machine learning web tool to track motion data using smartwatch sensors. Data from the accelerometer, heart rate sensor, gyroscope, gravity sensor and position sensor are tracked at 20 Hz. Our tool allows a systematic comparison of the performance between a Long Short-Term Memory (LSTM) model and the different sensor systems in classifying twelve nearly identical daily activities. In this paper, we address the problem of caregiver effort in creating daily care documentation for dementia patients. We present an activity classification system that enables automatic classification of daily activities of patients with dementia across a nursing shift. To assist caregivers, we provide an idea for integrating our system into a nursing documentation. • When monitoring the health state of people with neurological diseases, it is crucial to detect disease progression and disease-related changes as soon as possible. Such changes can be detected in the performance of everyday activities like eating, drinking, nose blowing, reading, looking at photos, knitting, telephoning, or brushing hair. • In order to supervise such everyday activities, this work proposes an approach employing smartwatches in combination with a Recurrent neural network. A smartwatch offers the possibility of integrating sensor technology into a patient’s daily routines in a unobtrusive way. • We have developed a machine learning web tool to track motion data using smartwatch sensors. Data from the accelerometer, heart rate sensor, gyroscope, gravity sensor and position sensor are tracked at 20 Hz. • Our tool allows a systematic comparison of the performance between a Long Short-Term Memory (LSTM) model and the different sensor systems in classifying twelve nearly identical daily activities. • In this paper, we address the problem of caregiver effort in creating daily care documentation for dementia patients. We present an activity classification system that enables automatic classification of daily activities of patients with dementia across a nursing shift. To assist caregivers, we provide an idea for integrating our system into a nursing documentation.

The Relationship Between Diet and Gastritis in Adolescents

Gastritis is a digestive tract problem that is most often found in daily life and a health problem that is often encountered. Habits of poor eating and consuming unhygienic food are risk factors for gastritis. Irregular eating patterns are caused by busy teenagers who are outside the home. The impact of gastritis can interfere with the patient's daily activities. Objective: This study aims to determine the relationship between diet and the incidence of gastritis in adolescents in the Work Area of the Cigugur Public Health Center, Pangandaran Regency in 2021. Methods: The research method used is a quantitative analysis using a cross-sectional approach. The population in this study were all adolescents aged 16-19 years in the Work Area of the Cigugur Health Center, Pangandaran Regency as many as 4,798 people. Samples were taken using the proportional random sampling technique to obtain a sample of 98 people. Results: The results of the study showed that the diet in adolescents, most of the respondents, namely 60 people (61.2%) had a bad diet, and the incidence of gastritis in adolescents, most of the respondents 56 people (57.1%) had gastritis and there was a relationship between the pattern of eating with the incidence of gastritis in adolescents because the value of > value (0.05 > 0.000) Conclusion: There is a significant relationship between diet and the incidence of gastritis in adolescents

SARC-F scores can predict health status and daily activity in patients with idiopathic pulmonary fibrosis.

The strength, assistance in walking, rising from a chair, climbing stairs, and falls questionnaire (SARC-F) is widely used for screening sarcopenia. We aimed to examine the association of SARC-F scores with the measurements of quality of life and activity in patients with idiopathic pulmonary fibrosis (IPF). This cross-sectional pilot study prospectively enrolled 54 patients with IPF who completed pulmonary function tests, the 6-min walk test, the chronic obstructive pulmonary disease assessment test (CAT), St. George's Respiratory Questionnaire (SGRQ), the Hospital Anxiety and Depression Scale, and a daily step count. The daily step count was measured continuously for 7 consecutive days using a tri-axis accelerometer device. The mean age was 73.6±7.9 years and the mean percent predicted forced vital capacity was 80.4%±15.6%. The median [interquartile range] SARC-F score, SGRQ total scores, and CAT scores were 2 [1-3.25], 28.8 [14.4-46.9], and 13 [7-22], respectively. SARC-F scores were correlated with the percent predicted forced vital capacity (r=-0.51, P<0.001), CAT score (r=0.57, P<0.001), SGRQ total score (r=0.77, P<0.001), Hospital Anxiety and Depression Scale anxiety score (r=0.31, P=0.025), and Hospital Anxiety and Depression Scale depression score (r=0.28, P=0.041). Linear regression analyses revealed that the 6-minute walk test (6MWT) (standardized β=0.33, P=0.011) and SARC-F score (standardized β=-0.39, P=0.005), but not the CAT score and SGRQ total score, were significant predictors for daily step count. SARC-F scores were correlated with health status and daily activity in patients with IPF. Further studies are warranted to validate the utility of the SARC-F in patients with IPF.

Work productivity and activity in patients with SAPHO syndrome: a cross-sectional observational study

BackgroundOur understanding of work productivity impairment among patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is limited. The purpose of this study was to provide an overview of work productivity loss in SAPHO syndrome patients through the use of the work productivity and activity impairment (WPAI) questionnaire, as well as to investigate the relationship between the WPAI and other disease-related indicators.MethodsPatients for this cross-sectional study were recruited from Peking Union Medical College Hospital (Beijing, China). The questionnaires incorporating the WPAI were administered, along with the inclusion of demographic data, disease-specific measures, and general health variables. The construct validity of the WPAI was evaluated via the correlations between WPAI outcomes and other measures. Wilcoxon rank-sum tests and nonparametric Kruskal‒Wallis tests were used for the comparison of the WPAI outcomes between known groups.ResultsA total of 376 patients were included, and 201 patients (53.5%) were employed. The medians (interquartile range [IQR]) of absenteeism, presenteeism, work productivity loss, and activity impairment were 0% (0–13%), 20% (0–40%), 20% (0–52%), and 30% (0–50%), respectively. All of the WPAI outcomes showed moderate to strong correlations with other generic and disease-specific measures (|r| = 0.43–0.75), except for absenteeism. Increasing disease activity and worse health status were significantly associated with increased impairments of work productivity and activity.ConclusionThis study highlights the negative effects of SAPHO syndrome on the work productivity and activity of patients, thus indicating good construct validity and discriminative ability of the WPAI. To reduce the economic burden, it is important to improve the work productivity and daily activity of patients by ameliorating clinical care.

S883 Impact of Fatigue on Work Productivity and Activity Impairment and Health Care Utilization in Patients With Inflammatory Bowel Disease

Introduction: Fatigue often impacts daily activities in patients with IBD and is commonly reported even in patients with inactive disease. We explored the impact of fatigue on work productivity and activity impairment (WPAI) and health care utilization (HCU). Methods: Data were analyzed from the CorEvitas IBD Registry, a prospective cohort of adult patients with Crohn’s Disease (CD) or ulcerative colitis (UC). Using data collected between May 3, 2017 and April 1, 2022, we compared WPAI and HCU among 1) subjects with high fatigue (PROMIS score > 55) vs low fatigue (PROMIS score < 55) at enrollment and 2) subjects whose fatigue score worsened vs subjects with persistently high fatigue at 6 months. Disease activity was assessed with Harvey Bradshaw Index (CD) or Partial Mayo (UC). Descriptive statistics, adjusted odds ratios and 95% CIs are reported. Results: High fatigue at enrollment was reported in 47% of 640 CD and 38% of 569 UC patients with 56% and 39% in remission, respectively. For both CD and UC, patients with high fatigue reported more absenteeism, presenteeism, work productivity loss, and daily activity impairment, and higher rates of HCU at enrollment compared to those with low fatigue (Table). In adjusted analyses, 17% of CD subjects had worsened fatigue at 6 months which correlated with 2.7 increased odds of worsening presenteeism (95% CI: 1.19-6.26) and a 2.6 increased odds of worsening daily activity impairment (95% CI 1.45-4.72) compared to those with persistently high fatigue (Figure a). For UC, high fatigue correlated with 2.9 increased odds of an IBD-related hospitalization (95% CI 1.02-7.99) and 3.8 increased odds of having an ER visit (95% CI 1.28-11.01) in the following 6 months. Further, 13% of UC subjects had worsened fatigue at 6 months and were found to have 2.2 increased odds of worsening daily activity impairment (95% CI 1.06-4.59) compared to those with persistently high fatigue (Figure b). Conclusion: Our data show that fatigue is prevalent in both CD and UC and persists in the absence of active inflammation. More severe fatigue is associated with concurrent work productivity and activity impairment in both UC and CD patients and more IBD-related HCU in the UC subjects. Treatment approaches that improve fatigue in our IBD population may help to lessen further disability.Figure 1.: Adjusted Association Between Worsening Fatigue vs Persistently High Fatigue at 6 Months and Change in Employment, Work Productivity and Activity Impairment, and Health Care Utilization at 6 Months in Patients with Crohn’s Disease or Ulcerative Colitis * Adjusted odds ratios were obtained using logistic regression models adjusted for age, sex, education, marital status, current alcohol use, history of CVD, history of respiratory, history of depression, history of anxiety, number of prior biologics/JAKi/S1P, concomitant steroids, duration of current IBD therapy, Harvey Bradshaw index score (continuous), and WPAI current employment † Adjusted odds ratios and p values were obtained using logistic regression models adjusted for age, sex, BMI continuous, private insurance, marital status, history of respiratory, history of anxiety, history of other non-serious medical condition, time since IBD diagnosis, prior IST experienced, prior steroid experienced, Harvey Bradshaw Index score (continuous), and WPAI current employment ‡ Adjusted odds ratios were obtained using logistic regression models adjusted for age, sex, smoking status, current alcohol use, history of CVD, history of depression, history of anxiety, history of other non-serious medical condition, pan-colitis, concomitant biologics/JAKi/S1P, concomitant 5-ASAs, duration of current IBD therapy (years), and Partial Mayo score (continuous) ‖ Adjusted odds ratios were obtained using logistic regression models adjusted for white race, Hispanic ethnicity, BMI categorical, smoking status, history of anxiety, history of other non-serious medical conditions, proctitis, pan-colitis, prior-antibiotic experienced, concomitant biologics/JAKi/S1P, concomitant 5-ASAs, and Partial Mayo score (continuous). Table 1. - Baseline Work Projectivity and Activity Impairment and Health Care Utilization Among Patients with Crohn’s Disease or Ulcerative Colitis having High Fatigue (PROMIS score ≥ 55) versus Low Fatigue (PROMIS score < 55) at Enrollment High Fatigue Low Fatigue Unadjusted p value Crohn's disease n=299 n=341 Absenteeism 45/169 (27%) 28/209 (13%) 0.001 Presenteeism 147/174 (85%) 113/222 (51%) < 0.001 Work productivity loss 143/167 (86%) 112/208 (54%) < 0.001 Daily activity impairment 255/298 (86%) 193/339 (57%) < 0.001 IBD-related hospitalizations 206/299 (69%) 203/340 (60%) 0.016 IBD-related ER visits 193/299 (65%) 185/340 (54%) 0.009 Ulcerative Colitis n=218 n=351 Absenteeism 48/131 (37%) 23/215 (11%) < 0001 Presenteeism 102/139 (73%) 120/232 (52%) < 0001 Work productivity loss 99/130 (76%) 117/215 (54%) < 0001 Daily activity impairment 176/217 (81%) 199/351 (57%) < 0001 IBD-related hospitalizations 109/218 (50%) 144/351 (41%) 0.036 IBD-related ER visits 111/218 (51%) 132/350 (38%) 0.002

Banana Ice Cream as An Eco-friendly Social Enterprise Product for Helping Cancer Patients During Treatment

Purpose: Banana ice cream is a fun food to eat and has both functions. The use of banana as main component of ice cream is expected to be a sustainable food, which is supporting Sustainable Development Goals (SDGs). The business of banana ice cream can be run for social purposes that make a profit, which will circle back for the needs of cancer patients.&#x0D; Design/methodology/approach: Break even point analysis used to determine economic feasibility of the business plan. Break even point would be reached when the total unit of selling banana ice cream as much as 3.024 scoops with sales value was 15.120.000 Indonesian Rupiah. The minimum time for recovering the initial investment was 151 days or 5 months. Banana ice cream business is feasible to be run.&#x0D; Findings: Cancer treatments often cause adverse effects at different levels. The adverse effect can greatly affect the patient's daily activities that may impair quality of life. New food products shall be developed to improve patient nutrition and reduce side effects from therapies.&#x0D; Originality/value: This paper is original&#x0D; Paper type: Research paper

Preoperative brain connectome predicts postoperative changes in processing speed in moyamoya disease

Moyamoya disease is a rare cerebrovascular disorder associated with cognitive dysfunction. It is usually treated by surgical revascularization, but research on the neurocognitive outcomes of revascularization surgery is controversial. Given that neurocognitive impairment could affect the daily activities of patients with moyamoya disease, early detection of postoperative neurocognitive outcomes has the potential to improve patient management. In this study, we applied a well-established connectome-based predictive modelling approach to develop machine learning models that used preoperative resting-state functional connectivity to predict postoperative changes in processing speed in patients with moyamoya disease. Twelve adult patients with moyamoya disease (age range: 23–49 years; female/male: 9/3) were recruited prior to surgery and underwent follow-up at 1 and 6 months after surgery. Twenty healthy controls (age range: 24–54 years; female/male: 14/6) were recruited and completed the behavioural test at baseline, 1-month follow-up and 6-month follow-up. Behavioural results indicated that the behavioural changes in processing speed at 1 and 6 months after surgery compared with baseline were not significant. Importantly, we showed that preoperative resting-state functional connectivity significantly predicted postoperative changes in processing speed at 1 month after surgery (negative network: ρ = 0.63, Pcorr = 0.017) and 6 months after surgery (positive network: ρ = 0.62, Pcorr = 0.010; negative network: ρ = 0.55, Pcorr = 0.010). We also identified cerebro-cerebellar and cortico-subcortical connectivities that were consistently associated with processing speed. The brain regions identified from our predictive models are not only consistent with previous studies but also extend previous findings by revealing their potential roles in postoperative neurocognitive functions in patients with moyamoya disease. Taken together, our findings provide preliminary evidence that preoperative resting-state functional connectivity might predict the post-surgical longitudinal neurocognitive changes in patients with moyamoya disease. Given that processing speed is a crucial cognitive ability supporting higher neurocognitive functions, this study’s findings offer important insight into the clinical management of patients with moyamoya disease.

105. Clinical outcomes of C2 nerve root sacrifice and the feasibility of its preservation in patients with congenital atlantoaxial instability

<h3>BACKGROUND CONTEXT</h3> Posterior C1-C2 fusion is a widely used fixation technique for atlantoaxial dislocation (AAD). The C2 ganglion is a restricting factor to easy access of C1-C2 joints, and placement of C1 lateral mass screws. Both intentional C2 nerve root sectioning as well as its preservation have been described and are still debatable. The associated complications and outcomes have been less studied, particularly in congenital AAD. <h3>PURPOSE</h3> To study clinical outcome after C2 nerve root sectioning as well as the feasibility of its preservation in AAD patients. <h3>STUDY DESIGN/SETTING</h3> Retrospective study/ tertiary care center. <h3>PATIENT SAMPLE</h3> This study included 190 patients who underwent posterior C1-C2 fusion for congenital AAD. <h3>OUTCOME MEASURES</h3> C2 nerve-related dysfunction; feasibilty of nerve root preservation. <h3>METHODS</h3> This is a retrospective study of 190 patients who underwent posterior C1-C2 fusion for congenital AAD using C1 lateral mass screws. The decision to cut or preserve C2 nerve root was dependent on preoperative radiology and intraoperative suitability of its preservation. Patients were followed-up at periodic intervals and questioned about C2 nerve-related dysfunction. <h3>RESULTS</h3> Complex C1-C2 morphology with highly deformed joints was seen in 139 patients. In 178 patients, the C2 nerve root was sectioned. Postoperative numbness, paresthesia and dysesthesia were present in 30.3%, 21.9% and 19.1% patients respectively. However, the symptoms were bothersome in none. They neither required medications nor disturbed the daily activities of patients. Noticeably, 9 patients (5.1%) developed non-healing occipital ulcers; most needed surgical intervention in the form of a flap cover/skin graft. C2 nerve root preservation is feasible with robust inferior C1 lateral mass and normal sized ganglion. In patients with C1-occipital condyle hypoplasia, highly oblique joints, incurved occiput, pseudofacets and anomalous vertebral artery, its preservation is technically difficult. <h3>CONCLUSIONS</h3> Though C2 nerve root sectioning did not disable the quality of life in many, a subset of patients was prone for neuropathic ulcers. Hence, its preservation should be attempted whenever feasible. It may be possible to preserve it in less complex anomalies/favorable anatomy. <h3>FDA DEVICE/DRUG STATUS</h3> This abstract does not discuss or include any applicable devices or drugs.

A Combination of Long-Duration Electrical Stimulation with External Shoulder Support during Routine Daily Activities in Patients with Post-Hemiplegic Shoulder Subluxation: A Randomized Controlled Study.

The study objective was to determine the effect of long-duration neuromuscular electric stimulation (NMES) on shoulder subluxation and upper-extremity function during the acute post-stroke stage. Twenty-eight subjects (mean age ± standard deviation −70.0 ± 14.0 years) were randomly assigned to an experimental or to a control group receiving NMES to the supraspinatus and posterior deltoid muscles or sham treatment for 6 weeks. All the subjects continued standard rehabilitation and external shoulder support (EST). Assessments were conducted pre- and post-intervention and at a 2 week follow-up session by an assessor blind to group allocation. Outcome measures included the degree of shoulder subluxation, Fugl–Meyer assessment-upper extremity (FMA-UE) test, FMA—hand and finger subscales, Functional Independence Measure (FIM), and shoulder pain (using the Numeric Pain Rate Scale). Shoulder subluxation was significantly lower, while the FMA-UE and FMA—hand and finger subscales were significantly improved in the experimental group post-intervention and at follow-up compared to the control group. FIM at follow-up improved more in the experimental group. No change was observed in pain level in both groups. Supplementing NMES to standard rehabilitation and EST is beneficial in reducing shoulder subluxation and improving upper-extremity function. Further research is necessary to determine effect of longer treatment duration and longer follow-up periods.

Tafalgin is a Russian innovative tetrapeptide pharmaceutical for subcutaneous injection: review of the results of phase I and II clinical trials

Introduction. pain syndrome significantly affects quality of life and daily activities of patients with cancer, especially at terminal stages of the disease. Opioid analgesics are considered the “gold standard” of therapy, but their use is associated with bureaucratic difficulties, as well as risk of a number of adverse events and drug dependency. Tafalgin is a Russian innovative tetrapeptide analgesic for subcutaneous injection. phase I and II clinical trials demonstrated its high effectiveness comparable to morphine and favorable safety profile.The study objective is to evaluate the safety, tolerability, and pharmacokinetics of tafalgin after subcutaneous injection in healthy volunteers, as well as effectiveness and safety of varying doses in patients with pain syndrome due to malignant tumors.Materials and methods. Phase I clinical trial included 39 healthy male volunteers. The drug was injected once subcutaneously at doses between 0.05 and 7 mg. plasma samples were obtained in the first 120 hours, and safety profile, tolerability and main pharmacokinetic characteristics of the pharmaceutical were determined. phase II clinical study included 42 patients with severe pain syndrome caused by malignant tumors who previously received morphine. At the 1st stage (10 days), all patients were randomized in groups receiving tafalgin at doses 2, 3, 4, 5, 6 or 7 mg (dosing frequency was determined individually); at the 2nd stage the patients were randomized into tafalgin (with dose determined at the 1st stage) and morphine (with dose determined prior to the clinical trial) groups and received the medications for 7 days. Effectiveness and safety of tafalgin compared to morphine and pharmacokinetic parameters of the studied drug were evaluated.Results. Tafalgin is characterized by fast absorption after subcutaneous administration (less than 30 minutes) which allows for fast clinical effect and absence of accumulation in the body. use of this pharmaceutical in patients with cancer allowed to maintain appropriate pain management achieved earlier through intramuscular morphine administration in 100 % of cases. Dynamics of mean daily pain intensity and necessity of additional analgesics did not differ between the groups. use of tafalgin did not require an increase in the dose or frequency of administration. Comparison of mean daily individual morphine and tafalgin doses showed that equianalgetic potential of the studied pharmaceutical was 1:3. Safety profile of tafalgin was favorable: adverse events during the trial were mild or moderate and not lifethreatening. use of tafalgin was associated with decreased number of opioid-induced adverse effects and improved quality of sleep in patients who previously received morphine parenterally.Conclusion. Data obtained during the first in Russia clinical trial of a new selective pharmaceutical tafalgin with tropism to opioid pl-receptors definitively demonstrates its high effectiveness and safety and shows the necessity of further studies in this field.

To study the effects of knee osteoarthritis on hip flexibility among elders.

Objectives: To determine the effect of knee osteoarthritis on hip flexibility by using Modified Thomas Test. Study Design: Observational study. Setting: Department of Physiotherapy and Orthopedic, Shalamar Hospital, Lahore. Period: 1 July 2021 to 31 December 2021. Material &amp; Methods: This study recruited 40 participants of either sex, age between 30- 70 years. Results: The response of study was 100%. Frequency of females with osteoarthritis was 82.5 males was 17.5%. Among the patients 33 were females and 7 were males. T-Test was performed for parameters of age in years, height in inches, weights in kgs for females and males. The mean age was 51.79±9.303 years for female and 55.43±8.404 years for male. Weight in kgs for female was 76.03±9.133 and for male was 94.57±20.911. In T test the height in inches for female was 61.45±2.399 and for male was 65.57±3.735. The co-relation between hip flexibility and knee osteoarthritis was moderately significant and flexibility was reduced because of osteoarthritis. Conclusion: It was concluded that hip flexibility is reduced with osteoarthritis of knee joint and due to reduced mobility of hip joint routine daily activities of patient was hampered.

Association Between Measures of Muscle Strength and Performance of Daily Activities in Patients with Knee Osteoarthritis.

ObjectivesMost studies of knee osteoarthritis use isokinetic peak strength as a measure of muscle strength. However, estimated one-repetition maximum (1-RM) may have a stronger relationship than isokinetic peak strength with daily activities. The aim of this study was to test the following hypotheses: first, the estimated 1-RM is more strongly associated than isokinetic peak strength with daily activities; and secondly, the estimated 1-RM is most strongly associated with the 6-minute walk test (6MWT), followed by the Get Up and Go test (GUG test) and the stair-climb test.MethodsData were used for 177 patients with knee osteoarthritis from a randomized controlled trial on improving muscle strength. The patients had a mean age of 67.6 ± 5.8 years. Isokinetic peak strength was measured using a dynamometer, 1-RM was estimated with the 10-RM test, and physical performance was measured with the 6-minute walk test (6MWT), get-up and go test (GUG) test and stair-climb test, at the start and end of 12 weeks of resistance training. Linear regression analyses provided standardized betas (β) that were comparable between the different associations between measures of muscle strength and daily activities.ResultsCompared with the estimated 1-RM, isokinetic peak strength was more strongly associated with all performance-based measures. The associations between the estimated 1-RM and performance-based tests were not ranked in the order hypothesized (6MWT, GUG test, stair-climb test).ConclusionContrary to the first hypothesis, isokinetic peak strength showed stronger associations with all daily activities than did estimated 1-RM. In addition, the second hypothesis regarding the activity-specific pattern for the 1-RM with regards walking, chair rising and stair climbing measurements was not confirmed.LAY ABSTRACTIn patients with knee osteoarthritis, greater muscle strength in the upper leg is linked with better performance in daily activities. To test muscle strength, peak muscle strength is usually measured. This study hypothesized that another test (the one-repetition maximum test) would be a more relevant measure. However, this was not confirmed, and therefore peak muscle strength remains the best measure of muscle strength at present.

Assessment of a new KoMaWo electrode-patch configuration accuracy and review of the literature

IntroductionStandard 12‑lead electrocardiogram (ECG) is a basic element of routine everyday clinical practice. Traditional cardiac monitoring devices are associated with considerable limitations. Adhesive patches, novel digital solutions, may become a useful diagnostic tool for several cardiovascular diseases. Materials and methodsWe propose a new variation of ECG electrodes positioning called KoMaWo. 15 consecutive patients presenting with ST segment deviations due to coronary artery disease were enrolled. The accuracy and utility of the new configuration was assessed and compared with the Mason-Likar configuration, as well as with a standard 12‑lead ECG recording. The scans were blinded and interpreted by two independent cardiologists. ResultsThere were no statistically significant differences in morphology, as well as in the duration of individual waves, complexes, segments, and intervals between the scans obtained using all three methods. In a subgroup analysis, with regard to age, body mass and left ventricle ejection fraction (LVEF), KoMaWo was non-inferior to standard ECG with a 0.2 mm margin. DiscussionThe role of traditional cardiac monitoring devices is recognized as the gold standard of patient management. However, certain limitations should be considered. Adhesive patches are light-weight, well-tolerated and do not interfere with daily activities of patients. These novel devices allow for extended monitoring, facilitating increased diagnostic accuracy, regarding cardiac arrhythmias. ConclusionsThe KoMaWo configuration is not inferior to standard electrode placement, nor to Mason-Likar configuration, including its ability to capture ST segment deviations. Adhesive patches may become a valid alternative for traditional cardiac monitoring methods.

심부전 환자의 신체적 수행 능력에 따른 도구적 일상생활 수준과 인지 수준의 연관성

Purpose: This study aimed to investigate the level of physical functional ability in patients with heart failure and to suggest the correlation between cognitive level and instrumental daily activity level with physical function ability. Methods: The study included individuals who were diagnosed with heart failure and those who were not diagnosed with stroke. Among 66 patients who were tested for weakness at S Hospital located in Gyeonggi-do from June 2021 to April 2022, data from 56 patients were selected and analyzed. Results: In the correlation between MMSE-K and SPPB, balance (r = .381, p &lt; .01), gait speed (r = .368, p &lt; .01), chair stand (r = .245, p &gt;.05), and total score (r = .387, p &lt; .01) showed a positive correlation except for the chair stand. In the correlation between K-IADL and SPPB, balance (r = −.532, p &lt; .01), gait speed (r = −.644, p &lt; .01), chair stand (r = −.391, p &lt; .01), and total score (r = −.600, p &lt; .01) showed a negative correlation. The higher the simple physical function, the higher the cognitive level and the lower the level of need for help in the level of instrumental daily activities. Conclusion: A correlation was found between the level of physical function and the level of cognitive and instrumental daily activities in patients with heart failure; thus, its evaluation is essential.