Event Abstract Back to Event Phenotyping of transgenic mice. Comparison of Intellicage–system to automatic monitoring of behaviour in social context with standard tests Anna Kiryk1* and Leszek Kaczmarek1 1 Nencki Institute of Experimental Biology, Poland There is a growing need for new strategies allowing for screening, monitoring and phenotyping of genetically modified animals. One of the instruments is IntelliCage system, an automated testing device allowing to investigate behavior in social groups of mice in repetitive conditions, without excessive contact with experimenter. We compared results of 4 strains of genetically modified mice tested individually in standard battery of tests with their performance in social context in IntelliCage. The overall behavior of tested strains, namely D2 knock-out mice lacking adult neurogenesis, GLT1 knock-out mice deprived of glial glutamate transporter, APP.V717I transgenic mice expressing the mutant human amyloid precursor protein and Dicer mice with forebrain specific and inducible inactivation of Dicer gene, were at first analyzed in sensorimotor tests, open field and elevated plus maze and then in IntelliCage system. We found that social housing in IntelliCage did not influence activity, exploration and anxiety level. Furthermore, learning and memory tests were conducted in IntelliCage, e.g. place preference and confronted with traditional learning tasks, such as Morris water maze. Again, social housing in IntelliCage had no noticeable effect on learning of individual mouse as we detected differences in phenotype mice with mutation from their wild-type siblings. However, when a group of APP.V717I transgenic mice had to cope with the same learning task in IntelliCage system, we found that social influence can affect the learning. Conference: 41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009. Presentation Type: Poster Presentation Topic: Poster presentations Citation: Kiryk A and Kaczmarek L (2009). Phenotyping of transgenic mice. Comparison of Intellicage–system to automatic monitoring of behaviour in social context with standard tests. Conference Abstract: 41st European Brain and Behaviour Society Meeting. doi: 10.3389/conf.neuro.08.2009.09.192 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 10 Jun 2009; Published Online: 10 Jun 2009. * Correspondence: Anna Kiryk, Nencki Institute of Experimental Biology, Granz, Poland, a.kiryk@nencki.gov.pl Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Anna Kiryk Leszek Kaczmarek Google Anna Kiryk Leszek Kaczmarek Google Scholar Anna Kiryk Leszek Kaczmarek PubMed Anna Kiryk Leszek Kaczmarek Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.