Landform geomorphology and glacial lake deposits in the largest drainage basin of the Ladakh Range i.e. Chang La-Tangtse basin were studied to infer their palaeoclimatic significance. The grain size, mineral magnetism, percentage loss on ignition (%LOI) and organic carbon stable isotope (δ13C) data in combination with total organic carbon (TOC) supported by AMS 14C (calibrated) dates of a 190 cm long section from the Chang La-Tsoltak palaeolake provides a climatic record since the last ∼ 7075 cal yr BP. The χlf, χARM, and SIRM values suggest that the catchment-derived palaeolake sediments predominantly contain magnetically “soft” minerals like magnetite and maghemite. The δ13C values range between −21 and −24 ‰ with an average of –22 ‰ which suggests a mixed C3-C4 plant signature and water stressed ecosystem. The relatively small variations in the δ13C values of organic matter in the entire lake profile suggest a stable climatic condition. The prominent effect of westerlies is seen between 7075 and 6040 cal yr BP with huge detrital influx at the lake bottom indicating a glacial advancement in the region. The affect of Mid-Holocene warm period is evident at 6040 cal yr BP with the advent of ISM. Paradigm shifts in the proxy values are observed at 5710, 4890, 3435, and 2800 cal yr BP. The influence of westerlies gradually reduces at 2800 cal yr BP. The landscape evolution and the climatic variations in the Trans-Himalaya are primarily governed by westerlies and do not correspond to the Indian monsoon variability records, particularly during the Mid-Holocene Thermal Maxima. Several other regions of the Ladakh Range also record similar climatic variations, indicating that the palaeolake sediments also reflect regional climate variations.