Abstract This study combines historical exploration data with new mapping, underpinned by airborne hyperspectral imagery, to provide a detailed camp-scale geologic view of the Rössing uranium mine area in the Damara orogen, Namibia. The Neoproterozoic Damaran metasedimentary host rocks to uranium deposits of the Rössing area structurally overlie Paleoproterozoic basement rock. Both units were subjected to polyphase deformation and upper amphibolite to lower granulite facies metamorphism during Pan-African orogenesis. The sequence was voluminously intruded by leucogranites, where younger phases may contain ore-grade uranium as magmatic uraninite and traces of betafite, together with secondary uranium minerals. Early, postdepositional modifications to the Damaran sequence included partial dolomitization of marble units and development of evaporite dissolution and diapiric breccias. Major pre-D3 extensional structures developed in conjunction with recumbent, isoclinal folding and acted to focus the intrusion of early, mostly barren leucogranites generated primarily through anatexis of Damaran metasediments. Syn-D4 leucogranites overprint complex interference fold geometries that resulted from D3 deformation. D4 leucogranites were emplaced under predominantly ductile, transtensional conditions, into NNE-trending zones oriented highly oblique to all preexisting structures. These steeply dipping zones provided the prerequisite conditions for partial melt material to be derived from uraniferous basement lithologies. The concentration of magmatic uranium was promoted where leucogranite melt material interacted with carbonates and sulfide-bearing Damaran metasedimentary units. In the Rössing area these horizons occur at the Khan-Rössing Formation contact zone for the SJ, SK, SH, Z20, and Husab deposits and within and above the Arandis Formation for the Z19 deposit leucogranites.