An enantioselective synthesis of the C 35 threo, trans, threo-mono-tetrahydrofuran annonaceous acetogenin longifolicin through use of chiral long-chain α-and γ-OMOM allylic stannanes and ( E)-ethyl 3-formyl-2-propenoate as the starting materials is described. The synthesis is structurally definitive and potentially applicable to other members of this family of cytotoxic acetogenins.