PurposeIn high-pressure pumps, due to the interaction of asperities on the upper and lower surfaces, the piston–cylinder interface suffers severe lubrication and sealing problems during mixed lubrication. This study aims to establish a mixed thermo-elastohydrodynamic (EHD) model for the lubrication gap to determine how working conditions affect the lubricating characteristics and sealing performance of the interface.Design/methodology/approachA mixed thermo-EHD lubrication model is established to investigate the lubricating characteristics and sealing performance of the interface between the piston and cylinder. The model considers piston tilting, thermal effect, surface roughness and bushing deformation. The interface lubricating characteristics and sealing performance under different working conditions are calculated by the proposed numerical model.FindingsA higher inlet pressure contributes to an increase in the minimum film thickness. Increased shaft speed can significantly reduce the minimum film thickness, resulting in severe wear. Compared to roughness, the impact of the thermal effect on the interface sealing performance is more significant.Originality/valueThe proposed lubrication model in this study offers a theoretical framework to evaluate the lubricating characteristics and sealing performance at the lubrication gap. Furthermore, the results provide references for properly selecting piston-cylinder surface processing parameters.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/ILT-03-2023-0072/