Road facilities in urban areas are a major source of injury for nonmotorized road users despite the benefits of nonmotorized transportation. In particular, large Canadian cities such as Montreal face serious problems with pedestrian and cyclist safety. To address these problems, funds are continually allocated through different safety improvement programs such as reduction of speed limits, improvement of intersections, and increased traffic enforcement. However, few analytical tools help to identify and quantify the benefits of countermeasures (e.g., roadway design, speed management strategies, or land use policies) in reducing accident frequency and severity. Injury severity models were developed to determine the effects of road design, built environment, speed limits, and other factors (e.g., vehicle characteristics and movement type) on injury severity levels of pedestrians and cyclists involved in collisions with motor vehicles. Sources of data included police reports describing vehicle–pedestrian and vehicle–cyclist collisions, as well as information on land use, transit network, and road design attributes from the city of Montreal. The impacts of road design, land use, built environment, and other strategies on the injury severity levels of vulnerable road users were investigated. Factors such as darkness, vehicle movement, whether an accident occurred at an intersection, vehicle type, and land use mix affected the severity of pedestrian injuries from collisions. For cyclists, however, only vehicle movement and whether the accident occurred at a signalized intersection had significant effects on the severity of the injury.