Abstract The dematerialization of the development of anthropized and anthropic systems/complexes represents an objective of maximum importance for ensuring the coevolution of human activities and the natural environment, from the perspective of sustainability requirements. In this context, the use of methods for analyzing the reciprocal flows between the natural environment as a system and the socioeconomic system, in physical and energetic expression, provides us with the information support necessary to adopt measures to reduce specific consumption of ecosystem goods, respectively pressure on biophysical support of socio-economic systems, regardless of the spatial scale at which they are identified. Approaches in the field of industrial ecology, but not only, have highlighted the need and possibility of material flows cycling, but this is a first step towards dematerializing the development of anthropogenic and anthropic systems/complexes. From the perspective of global performance, research is needed on cost/benefit analysis of decisions in this regard and evaluation of effects/impacts on structural and functional processes at the level of technical-productive organizations.