In nature, a slope stability is determined by the ratio of a sliding resistance to a slide force. The slide force of a marine deep-water continental slope is mainly affected by sediment mechanics properties, a topography, and a marine seismic. However, the sliding resistance is mainly affected by sedimentary patterns and a sedimentary stress history. Both of these are different from case to case, and their impact can be addressed when the data are organized in a geographic information system (GIS). The study area on the continental slope in Zhujiang River Mouth Basin in South China Sea provides an excellent opportunity to apply GIS spatial analysis technology for the evaluation of the slope stability. In this area, a continental slope topography and a three-dimension (3–D) topography mapping show a sea-floor morphology and the distribution of a slope steepness in good detail, and the sediment analysis of seabed samples and an indoor appraisal reveals the variability of a sediment density near the sea-floor surface. On the basis of the results of nine geotechnical studies of submarine study areas, it has worked out that an equivalent cyclic shear stress ratio is roughly between 0.158 and 0.933, which is mainly depending on the initial water content of sediment. A regional density, slope and level of anticipated seismic shaking information are combined in a GIS framework to yield a map that illustrates a continental slope stability zoning under the influencing factors in Zhujiang River Mouth Basin in the South China Sea. The continental slope stability evaluation can contribute to north resources development in the South China Sea, the marine functional zoning, the marine engineering construction and adjust measures to local conditions, at the same time also can provide references for other deep-water slope stability analysis.