Cyclic Production Research Articles

Extended Solution-phase Peptide Synthesis Strategy Using Isostearyl-Mixed Anhydride Coupling and a New C-Terminal Silyl Ester-Protecting Group for N-Methylated Cyclic Peptide Production

Extended Solution-phase Peptide Synthesis Strategy Using Isostearyl-Mixed Anhydride Coupling and a New C-Terminal Silyl Ester-Protecting Group for <i>N</i>-Methylated Cyclic Peptide Production

Alkali metal (Na, Cs and K) promoted hydrotalcites for high temperature CO2 capture from flue gas in cyclic adsorption processes

A hydrotalcite (HT) with a Mg2+/Al3+ molar ratio of 2 was prepared and promoted with different loadings of Na and Cs. After calcination (denoted as CHT), the samples were tested for CO2 sorption at 573 K and 0.15eg bar of CO2 (typical of flue gas). Their performance was compared to that achieved with a commercial HT, MG63, and with a K-doped material for which a significant increase of CO2 sorption capacity has been frequently reported in the literature. However, the presence of K slows down the sorption kinetics, which might compromise the cyclic separation process productivity. In this work, it is aimed to find out a CO2 HT-based sorbent with promising behaviour during continuous sorption/desorption cycles, in terms of sorption capacity, sorption kinetics and cyclic stability. The best compromise was observed for a CHT doped with 9.4 wt% of Cs. A study of the cyclic stability of this material was performed and a kinetic model that can predict the loss of sorption capacity with cycles has been successfully developed. The performance of this sorbent was further investigated in a scenario where other species found in flue gas streams (i.e. O2, H2O and/or CO) are also present.

Enhanced Cyclic Adenosine Monophosphate Fermentation Production by Aminophylline and Citrate Coupling Addition

Enhanced Cyclic Adenosine Monophosphate Fermentation Production by Aminophylline and Citrate Coupling Addition

Evaluation on the dynamic sealing capacity of underground gas storages rebuilt from gas reservoirs: A case study of Xinjiang H underground gas storage

In order to provide effective guidance for optimizing and adjusting the maximum operation pressure and dynamic monitoring well pattern of underground gas storages (hereinafter referred as gas storages) and ensure the operation safety of gas storages, this paper takes Xinjiang H gas storage whose storage capacity and peak shaving capacity are the highest in China as the research object to establish a 3D fine geological model and a 3D dynamic geomechanical model in the regional scale of H gas storage based on the alternating change characteristics of geostress field during the high-speed cyclic injection and production of gas storage, combined with the geological, seismic, logging and various laboratory core experiment results. Then, the trap dynamic sealing capacity of H gas storage under the action of alternating stress after 14 years of depletion development of its original gas reservoir and long-term high-speed injection and production after its reconstruction from the gas reservoir was evaluated comprehensively. And the following research results were obtained. First, the change of the formation pressure in H gas storage has a significant effect on the regional geostress field. Second, after the development of the original H gas reservoir, the geostress on the two sides of the fault are greatly different, but the cap rock is not deformed and failed and the reservoir controlling fault as the gas bearing boundary doesn't glide, which ensures the safety of reconstructing H gas reservoir into gas storage. Third, due to the high-speed injection and production of H gas storage, the geostress field becomes more uneven, which has a potential negative impact on the integrity of the injection and production wells of the gas storage. Fourth, during the long-term high-speed injection and production operation of H gas reservoir, the cap rock does not undergo shear and tensile failure, but the numerical simulation of geomechanics shows that the long-term high-speed injection and production of the gas storage results in the relative sliding deformation (maximum about 5 cm) on both sides of H fault in the south of the reservoir, so the sealing capacity of H fault is a weak point impacting the integrity of the gas storage. Fifth, it is recommended to deploy monitoring wells at the upper block of H fault in the south of the gas storage to strengthen the injection and production dynamic monitoring. In conclusion, this study performs a qualitative and quantitative evaluation on the trap dynamic sealing capacity of gas storages rebuilt from gas reservoirs under the action of alternating stress, and it plays an important guiding role in ensuring the long-term injection and production safety of H gas storage.

Exosomes from human umbilical cord mesenchymal stem cells inhibit ROS production and cell apoptosis in human articular chondrocytes via the miR-100-5p/NOX4 axis.

Cyclic strain-induced chondrocyte damage is actively involved in the pathogenesis of osteoarthritis and arthritis. MicroRNAs (miRNAs) carried by exosomes have been implicated in various diseases. However, the role of miR-100-5p in cyclic strain-induced chondrocyte damage remains to be elucidated. miR-100-5p and NADPH oxidase 4 (NOX4) were silenced or overexpressed in human primary articular chondrocytes. PKH-67 Dye was used to trace exosome endocytosis. Reactive oxygen species (ROS) production was monitored using DCFH-DA. Cell apoptosis was measured using a flow cytometer. Quantitative RT-PCR and Western blots were used to evaluate gene expression. Cyclic strain promoted ROS production and apoptosis in primary articular chondrocytes in a time-dependent manner. HucMSCs-derived exosomal miR-100-5p inhibited cyclic strain-induced ROS production and apoptosis in primary articular chondrocytes. miR-100-5p directly targeted NOX4. Overexpressing NOX4 attenuated hucMSCs-derived exosomes-mediated protective effects in primary articular chondrocytes. Cyclic strain promotes ROS production and apoptosis in primary articular chondrocytes, which was abolished by hucMSCs-derived exosomal miR-100-5p through its target NOX4. The findings highlight the importance of miR-100-5p/NOX4 axis in primary articular chondrocytes injury and provide new insights into therapeutic strategies for articular chondrocytes injury and osteoarthritis.

Synergies at the level of motor units in single-finger and multi-finger tasks.

We explored the organization of motor units recorded in the flexor digitorum superficialis into stable groups (MU-modes) and force-stabilizing synergies in spaces of MU-modes. Young, healthy participants performed one-finger and three-finger accurate cyclical force production tasks. Two wireless sensor arrays (Trigno Galileo, Delsys, Inc.) were placed over the proximal and distal portions of the muscle for surface recording and identification of motor unit action potentials. Principal component analysis with Varimax rotation and factor extraction was used to identify MU-modes. The framework of the uncontrolled manifold hypothesis was used to analyze inter-cycle variance in the space of MU-modes and compute the index of force-stabilizing synergy. Multiple linear regression between the first MU-mode in the three-finger task and the first MU-modes in the three single-finger tasks showed no differences between the data recorded by the two electrodes suggesting that MU-modes were unlikely to be synonymous with muscle compartments. Multi-MU-mode synergies stabilizing task force were documented across all tasks. In contrast, there were no force-stabilizing synergies in the three-finger task analyzed in the space of individual finger forces. Our results confirm the synergic organization of motor units in single-finger tasks and, for the first time, expand this result to multi-finger tasks. We offer an interpretation of the findings within the theoretical scheme of control with spatial referent coordinates expanded to the analysis of individual motor units. The results confirm trade-offs between synergies at different hierarchical levels and expand this notion to intra-muscle synergies.

Glucagon regulates the stability of REV-ERBα to modulate hepatic glucose production in a model of lung cancer-associated cachexia.

Lung adenocarcinoma is associated with cachexia, which manifests as an inflammatory response that causes wasting of adipose tissue and skeletal muscle. We previously reported that lung tumor-bearing (TB) mice exhibit alterations in inflammatory and hormonal signaling that deregulate circadian pathways governing glucose and lipid metabolism in the liver. Here, we define the molecular mechanism of how de novo glucose production in the liver is enhanced in a model of lung adenocarcinoma. We found that elevation of serum glucagon levels stimulates cyclic adenosine monophosphate production and activates hepatic protein kinase A (PKA) signaling in TB mice. In turn, we found that PKA targets and destabilizes the circadian protein REV-ERBα, a negative transcriptional regulator of gluconeogenic genes, resulting in heightened de novo glucose production. Together, we identified that glucagon-activated PKA signaling regulates REV-ERBα stability to control hepatic glucose production in a model of lung cancer-associated cachexia.

Integration of cryogenic trap to gas chromatography-sulfur chemiluminescent detection for online analysis of hydrogen gas for volatile sulfur compounds

Hydrogen fuel cells are among the promising energy sources worldwide, which could accomplish cyclic production of energy and avoid the emission of green-house or contaminative byproducts. However, sulfur compounds (SCs) even at trace level (nmol/mol) are usually involved in cell construction and further H2 production, which would cause degradation of the catalysts and shorten the lifetime of the fuel cells. Moreover, the highly reactive SCs could cause varied species and concentrations of them in complex matrices, so online rather than offline analysis of SCs in H2 would be preferred. In this context, we developed a new system combining online cryogenic preconcentration of nine SCs and subsequent determination by GC-SCD (sulfur chemiluminescent detector), with the correlation coefficients of the calibration curves higher than 0.999, calculated limits of detection no higher than 0.050 nmol/mol, analytical time around 30 min per sample, and satisfactory precision and accuracy (RSD < 5% and SD < 15%). The analytical performance was much better than or at least comparable to the previously reported and the developed system was successfully applied for real sample analysis.

The high energetic cost of rapid force development in muscle.

Muscles consume metabolic energy for active movement, particularly when performing mechanical work or producing force. Less appreciated is the cost for activating muscle quickly, which adds considerably to the overall cost of cyclic force production. However, the cost magnitude relative to the cost of mechanical work, which features in many movements, is unknown. We therefore tested whether fast activation is costly compared with performing work or producing isometric force. We hypothesized that metabolic cost would increase with a proposed measure termed force rate (rate of increase in muscle force) in cyclic tasks, separate from mechanical work or average force level. We tested humans (N=9) producing cyclic knee extension torque against an isometric dynamometer (torque 22 N m, cyclic waveform frequencies 0.5-2.5 Hz), while also quantifying quadriceps muscle force and work against series elasticity (with ultrasonography), along with metabolic rate through respirometry. Net metabolic rate increased by more than four-fold (10.5 to 46.8 W) with waveform frequency. At high frequencies, the hypothesized force-rate cost accounted for nearly half (40%) of energy expenditure. This exceeded the cost for average force (17%) and was comparable to the cost for shortening work (43%). The force-rate cost is explained by additional active calcium transport necessary for producing forces at increasing waveform frequencies, owing to rate-limiting dynamics of force production. The force-rate cost could contribute substantially to the overall cost of movements that require cyclic muscle activation, such as locomotion.

LHCGR and ALMS1 defects likely cooperate in the development of polycystic ovary syndrome indicated by double-mutant mice

Polycystic ovary syndrome (PCOS) is a heterogeneous disorder with evidence of polygenetic components, and obesity may be a risk factor for hyperandrogenism. Previous studies have shown that LHCGR is enriched in the ovary and LHCGR deficiency causes infertility without typical PCOS phenotypes. ALMS1 is implicated in obesity and hyperandrogenism, the common phenotypes among PCOS patients. Through whole-exome sequencing of 22 PCOS families and targeted candidate gene sequencing of additional 65 sporadic PCOS patients, we identified potential causative mutations in LHCGR and ALMS1 in a sibling-pair PCOS family and three sporadic PCOS patients. The expression of LHCGRL638P in granulosa-like tumor cell line (KGN) cells promoted cyclic adenosine monophosphate production and granulosa cell proliferation, indicating that LHCGRL638P is an activating mutation. LhcgrL642P/L642P mice showed an irregular estrous cycle, reduced follicles with dynamic folliculogenesis, and increased testosterone (T), estradiol (E2), and dehydroepiandrosterone. Lhcgr+/L642PAlms1+/PB mice displayed increased T and E2 but decreased late secondary and preovulatory follicles. We showed that activating mutation of LHCGR likely plays important roles in the pathophysiology of PCOS involving abnormal reproductive physiology, whereas ALMS1 deficiency may promote anovulatory infertility via elevated androgens, suggesting that the disturbed LHCGR and ALMS1 cooperatively induce PCOS phenotypes, characterized as anovulation and hyperandrogenemia frequently observed in PCOS patients with obesity.

A Novel Gene vp0610 Negatively Regulates Biofilm Formation in Vibrio parahaemolyticus.

Vibrio parahaemolyticus is an important foodborne pathogen and its biofilm formation ability facilitates its colonization and persistence in foods by protecting it from stresses including environmental variation and antibiotic exposure. Several important proteins are involved in biofilm formation; however, the identity and function of many remain unknown. In this study, we discovered a hypothetical protein, VP0610 that negatively regulates biofilm formation in Vibrio parahaemolyticus, and we found that the loss of vp0610 typically results in pleiotropic phenotypes that contribute toward promoting biofilm formation, including significantly increased insoluble exopolysaccharide production and swimming motility, decreased soluble exopolysaccharide production, and decreased bis-(3′-5′)-cyclic dimeric guanosine monophosphate production. Pull-down assays revealed that VP0610 can interact with 180 proteins, some of which (Hfq, VP0710, VP0793, and CyaA) participate in biofilm formation. Moreover, deleting vp0610 enhanced the expression of genes responsible for biofilm component (flaE), the sugar phosphotransferase system (PTS) EIIA component (vp0710 and vp0793), and a high-density regulator of quorum sensing (opaR), while reducing the expression of the bis-(3′-5′)-cyclic dimeric guanosine monophosphate degradation protein (CdgC), resulting in faster biofilm formation. Taken together, our results indicate that vp0610 is an integral member of the key biofilm regulatory network of V. parahaemolyticus that functions as a repressor of biofilm formation.

Systemic metabolite profiling reveals sexual dimorphism of AIBP control of metabolism in mice.

Emerging studies indicate that APOA-I binding protein (AIBP) is a secreted protein and functions extracellularly to promote cellular cholesterol efflux, thereby disrupting lipid rafts on the plasma membrane. AIBP is also present in the mitochondria and acts as an epimerase, facilitating the repair of dysfunctional hydrated NAD(P)H, known as NAD(P)H(X). Importantly, AIBP deficiency contributes to lethal neurometabolic disorder, reminiscent of the Leigh syndrome in humans. Whereas cyclic NADPHX production is proposed to be the underlying cause, we hypothesize that an unbiased metabolic profiling may: 1) reveal new clues for the lethality, e.g., changes of mitochondrial metabolites., and 2) identify metabolites associated with new AIBP functions. To this end, we performed unbiased and profound metabolic studies of plasma obtained from adult AIBP knockout mice and control littermates of both genders. Our systemic metabolite profiling, encompassing 9 super pathways, identified a total of 640 compounds. Our studies demonstrate a surprising sexual dimorphism of metabolites affected by AIBP deletion, with more statistically significant changes in the AIBP knockout female vs male when compared with the corresponding controls. AIBP knockout trends to reduce cholesterol but increase the bile acid precursor 7-HOCA in female but not male. Complex lipids, phospholipids, sphingomyelin and plasmalogens were reduced, while monoacylglycerol, fatty acids and the lipid soluble vitamins E and carotene diol were elevated in AIBP knockout female but not male. NAD metabolites were not significantly different in AIBP knockout vs control mice but differed for male vs female mice. Metabolites associated with glycolysis and the Krebs cycle were unchanged by AIBP knockout. Importantly, polyamine spermidine, critical for many cellular functions including cerebral cortex synapses, was reduced in male but not female AIBP knockout. This is the first report of a systemic metabolite profile of plasma samples from AIBP knockout mice, and provides a metabolic basis for future studies of AIBP regulation of cellular metabolism and the pathophysiological presentation of AIBP deficiency in patients.

Revision of the genus Aciculosporium (Clavicipitaceae) with a description of a new species on wavyleaf basketgrass, and proline-containing cyclic dipeptide production by A. take.

The genus Aciculosporium (Clavicipitaceae, Hypocreales, Ascomycota)was established in 1908 for A. take , which is the causal fungus of witches' broom of bamboo. Although the original description was valid at that time, a type specimen for A. take has not been designated. To standardize the use of this genus and species name, a neotypification and reference specimen of A. take are proposed. Multilocus phylogenetic analyses based on DNA sequences from 28S rDNA, TEF, Tub2, Mcm7, and RPB2 revealed that A.sasicola is from a different lineage to A. take, and other specimens from wavyleaf basket grass (Oplismenus undulatifolius) represent a distinct species proposed here as Aciculosporium oplismeni sp. nov. Chemical analysis using mass spectrometry and nuclear magnetic resonance spectroscopy showed that A. take produces four proline-containing cyclic dipeptides, which are moieties of ergot alkaloids. However, ergot alkaloids, lolines, peramine, indole-diterpenes, and lolitrem were not detected in the culture solvent. This study offers clarification of the lineage and morphology of this genus.

In Vitro and In Vivo Effects of Palmaria palmata Derived Peptides on Glucose Metabolism

Three synthetic peptides, ILAP, LLAP and MAGVDHI, derived from a Palmaria palmata protein hydrolysate were assessed for their antidiabetic potential in vitro and in vivo. In addition to inhibiting dipeptidyl peptidase-IV in a cell-based in situ assay all three peptides significantly increased the half-life of the incretin hormone glucagon-like peptide-1 (GLP-1). ILAP and LLAP mediated a significant increase (p < 0.001) in insulin secretion from BRIN-BD11 cells compared to the glucose control, while MAGVDHI had no insulinotropic activity at an eqimolar concentration (10–6 M). A significant increase in the concentration of cyclic adenosine monophosphate production in BRIN-BD11 cells mediated by ILAP (p < 0.001) and LLAP (p < 0.01) compared to the basal control, would indicate that insulin secretion may be mediated by membrane based activation. Furthermore, ILAP and LLAP acted as glucose-dependent insulinotropic polypeptide (GIP) secretagogues, stimulating a significant increase (p < 0.01) in the concentration of GIP released from enteroendocrine STC-1 cells compared to the glucose control. When tested in vivo in healthy male NIH Swiss mice, ILAP and LLAP, mediated a significant increase (p < 0.01) in plasma insulin and decrease (p < 0.05) in blood glucose, respectively, compared to the control. MAGVDHI mediated a significant (p < 0.001) sustained reduction in food intake in food deprived trained mice. These results demonstrate that the Palmaria palmata peptides studied herein have prospective antidiabetic activity and have the potential to act as agents that can be used alone or in combination with drugs, to aid in the prevention and management of Type 2 diabetes mellitus.

An improved imperfect maintenance strategy for multiperiod randomly failing equipment with stochastic repair times

PurposeIn this paper, a maintenance strategy based on improved imperfect maintenance actions with stochastic repair times for multiperiod randomly failing equipment is developed. The main objective is to minimize the total maintenance cost by jointly finding the optimal preventive maintenance (PM) cycle and planning horizon.Design/methodology/approachA model based on the mathematical theory of reliability is developed to minimize the total maintenance cost by jointly finding the optimal couple: PM cycle T* and planning horizon H*. The proposed model aims to characterize the evolutionary impact of imperfect PM actions on the equipment failure rate and the resulting mean number of failures. The conventional threshold accepting (TA) algorithm is implemented to solve the proposed model. A numerical example for a given set of input parameters is presented in order to show the usefulness of the proposed model. A sensitivity analysis of some of the key parameters is performed to demonstrate the coherence of the developed maintenance policy.FindingsThe obtained results showed a sensitive trade-off between PM frequency and the total maintenance cost. Performing PM actions more frequently helps significantly to reduce the expected number of corrective maintenance actions and the corresponding total cost. It has also been found that improving the efficiency of the PM actions allows for maintaining the equipment less frequently by increasing the time between successive PM actions.Research limitations/implicationsGiven the complexity of the objective function to be minimized and the stochastic nature of the model's parameters, the authors limited this study to equally cyclic production periods over the planning horizon.Practical implicationsThe present model aims to provide an integrated maintenance/production comprehensive framework to assist planners in establishing maintenance schedules considering multiperiod randomly failing production systems and the evolutionary impact of imperfect PM actions on the equipment failure rate.Originality/valueContrary to the majority of existing works in the literature dealing with maintenance strategies, the authors consider that repair times are stochastic to provide a more realistic framework. In addition, the developed model considers the impact of imperfect maintenance on the equipment's mean time to failure. Thus, the evolutionary impact of imperfect PM actions on the equipment failure rate and the resulting mean number of failures is characterized. Simultaneously, the production planning horizon along with the length of each PM cycle is optimized in order to minimize the total maintenance cost over the planning horizon.

Evaluation of Energy Storage Potential of Unconventional Shale Reservoirs Using Numerical Simulation of Cyclic Gas Injection

Abstract Compressed air energy storage (CAES) stores energy as compressed air in underground formations, typically salt dome caverns. When electricity demand grows, the compressed air is released through a turbine to produce electricity. CAES in the US is limited to one plant built in 1991, due in part to the inherent risk and uncertainty of developing subsurface storage reservoirs. As an alternative to CAES, we propose using some of the hundreds of thousands of hydraulically fractured horizontal wells to store energy as compressed natural gas in unconventional shale reservoirs. To store energy, produced or “sales” natural gas is injected back into the formation using excess electricity and is later produced through an expander to generate electricity. To evaluate this concept, we performed numerical simulations of cyclic natural gas injection into unconventional shale reservoirs using cmg-gem commercial reservoir modeling software. We tested short-term (diurnal) and long-term (seasonal) energy storage potential by modeling well injection and production gas flowrates as a function of bottom-hole pressure. First, we developed a conceptual model of a single fracture stage in an unconventional shale reservoir to characterize reservoir behavior during cyclic injection and production. Next, we modeled cyclic injection in the Marcellus shale gas play using published data. Results indicate that Marcellus unconventional shale reservoirs could support both short- and long-term energy storage at capacities of 100–1000 kWe per well. The results indicate that energy storage in unconventional shale gas wells may be feasible and warrants further investigation.

Carbon dioxide inhibits UVB-induced inflammatory response by activating the proton-sensing receptor, GPR65, in human keratinocytes

Carbon dioxide (CO2) is the predominant gas molecule emitted during aerobic respiration. Although CO2 can improve blood circulation in the skin via its vasodilatory effects, its effects on skin inflammation remain unclear. The present study aimed to examine the anti-inflammatory effects of CO2 in human keratinocytes and skin. Keratinocytes were cultured under 15% CO2, irradiated with ultraviolet B (UVB), and their inflammatory cytokine production was analyzed. Using multiphoton laser microscopy, the effect of CO2 on pH was observed by loading a three-dimensional (3D)-cultured epidermis with a high-CO2 concentration formulation. Finally, the effect of CO2 on UVB-induced erythema was confirmed. CO2 suppressed the UVB-induced production of tumor necrosis factor-α (TNFα) and interleukin-6 (IL-6) in keratinocytes and the 3D epidermis. Correcting medium acidification with NaOH inhibited the CO2-induced suppression of TNFα and IL-6 expression in keratinocytes. Moreover, the knockdown of H+-sensing G protein-coupled receptor 65 inhibited the CO2-induced suppression of inflammatory cytokine expression and NF-κB activation and reduced CO2-induced cyclic adenosine monophosphate production. Furthermore, the high-CO2 concentration formulation suppressed UVB-induced erythema in human skin. Hence, CO2 suppresses skin inflammation and can be employed as a potential therapeutic agent in restoring skin immune homeostasis.

Cyclic methane hydrate production stimulated with CO2 and N2

The cyclic methane hydrate production method was proposed with CO2 and N2 mixture stimulation. The cyclic production model was established based on actual hydrate reservoir parameters, accordingly, the production characteristics were analyzed, and a sensitivity analysis was conducted. The results show the following: (1) The depressurization mechanism is dominant in the cyclic production. CH4 production and CH4 hydrate dissociation can be greatly enhanced because the cyclic process can effectively reduce the partial pressure of CH4 (gas phase). However, there is a limited effect for CO2 storage. (2) Heat supply is essential for continuous hydrate dissociation. The CH4 hydrate dissociation degree is the highest in the near-wellbore area; in addition, the fluid porosity and effective permeability are significantly improved, and the reservoir temperature is obviously decreased. (3) The initial CH4 hydrate saturation, absolute permeability, intrinsic CO2 hydrate formation kinetic constant, injection time and production time can significantly influence the production performance of the natural gas hydrate reservoir.

Synthesis of amino alcohols, cyclic urea, urethanes, and cyclic carbonates and tandem one-pot conversion of an epoxide to urethanes using a Zn–Zr bimetallic oxide catalyst

The one-pot tandem synthesis of urethanes directly from an epoxide, with urea in solvent-free condition using Zn2ZrOx is demonstrated. The catalyst exhibits excellent activity in cyclic urea, urethane, and cyclic carbonate production in neat conditions.

Cyclic oxygen exchange capacity of Ce-doped V2O5 materials for syngas production via high-temperature thermochemical-looping reforming of methane.

Synthesis gas production via solar thermochemical reduction-oxidation reactions is a promising pathway towards sustainable carbon-neutral fuels. The redox capability of oxygen carriers with considerable thermal and chemical stability is highly desirable. In this study, we report Ce-doped V2O5 structures for high-temperature thermochemical-looping reforming of methane coupled to H2O and CO2 splitting reactions. Incorporation of fractional amounts of large cerium cations induces a V5+ to V3+ transition and partially forms a segregated CeVO4 phase. More importantly, the effective combination of efficient ion mobility of cerium and high oxygen exchange capacity of vanadia achieves synergic and cyclable redox performance during the thermochemical reactions, whereas the pure vanadia powders undergo melting and show non-cyclic redox behaviour. These materials achieve noteworthy syngas production rates of up to 500 mmol molV−1 min−1 during the long-term stability test of 100 CO2 splitting cycles. Interestingly, the cerium ions are mobile between the lattice and the surface of the Ce-doped vanadia powders during the repeated reduction and oxidation reactions and contribute towards the cyclic syngas production. However, this also causes the formation of the CeVO4 phase in Ce-rich powders, which increases the H2/CO ratios and lowers fuel selectivity, which can be controlled by optimizing the cerium concentration. These findings are noteworthy towards the experimental approach of evaluating the oxygen carriers with the help of advanced characterization techniques.