Human skin has complex sensors to perceive three-dimensional stimuli from the environment. Skin-inspired flexible sensors with multidimensional and directional perception are desirable for applications in intelligent robots and human–machine interaction. Herein, wearable multidimensional sensors have been fabricated by macroscopically assembling 3D-printed microstructured anisotropic organohydrogel sensory units through robust interfacial adhesion. The organohydrogel is crosslinked using microgels and starch microparticles through non-covalent interactions, and composited with short carbon fibers as conductive fillers. The physical network exhibits low hysteresis against 5000 cyclic loadings, which demonstrates excellent robustness in both mechanical properties and sensory performance. The organohydrogel precursor is printed into a cone-shaped sensor with a pressure sensitivity 50 times higher than that of its bulk counterpart. A sea cucumber epidermis-like microstructured sensor with abundant highly sensitive cone array is assembled with 3D-printed anisotropic gels with highly aligned carbon fibers inside, generating a multidimensional sensor capable of perceiving stimuli along X-, Y-, and Z-axis. The assembled sensor can directionally distinguish external forces and identify human motions. This study demonstrates a promising strategy to fabricate well-structured organohydrogel sensors for applications in electronic skin, biomimetic flexible electronics, and artificial intelligence.