Salmonella are bacteria that cause numerous illnesses in humans and animals. In poultry farming, they cause major economic losses for farmers. In fact, during the poultry production cycle, poultry are frequently infected by Salmonella and are exposed to oxidative stress. To deal with these problems, farmers use antibiotics. Unfortunately, overuse of these molecules has led to resistance. The aim of this study was to evaluate the in vivo therapeutic and antioxidant activities of aqueous extract of the leaves from Anogeissus leiocarpus in Salmonellosis induced in broiler chicks. For the experimental study, 4 batches of 25 broiler chicks each were produced, including : - Batch 1 : uncontaminated chicks not treated with plant extract (NC-NT). - Batch 2 : chicks contaminated and not treated with plant extract (C-NT). - Batch 3 : chicks contaminated and treated with plant extract (C-T. extr). -Batch 4 : chicks contaminated and treated only with a standard antibiotic, oxytetracycline (C-T.OTC). The aqueous extract of Anogeissus leiocarpus gave the best results compared with oxytetracycline. These include the significant improvement in average weight gain and biomarkers of oxidative stress. The results obtained from this study show that the aqueous extract of Anogeissus leiocarpus can be used as an alternative to antibiotics in poultry farming. Keywords : Anogeissus leiocarpus, Extracts, Salmonella typhimurium, therapeutic activity.