Breaking Insights| July 05 2022 Highlights from Recent Cancer Literature Author & Article Information Online Issn: 1538-7445 Print Issn: 0008-5472 ©2022 American Association for Cancer Research2022American Association for Cancer Research Cancer Res (2022) 82 (13): 2327–2328. https://doi.org/10.1158/0008-5472.CAN-82-13-BI Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Article Versions Icon Versions Version of Record July 5 2022 Citation Highlights from Recent Cancer Literature. Cancer Res 1 July 2022; 82 (13): 2327–2328. https://doi.org/10.1158/0008-5472.CAN-82-13-BI Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest Search Advanced Search A current limitation of the effectiveness of immunotherapies has toxic effects on the immune system in noncancerous tissues. To identify immune pathways unique to tumors, Mair and colleagues compared immune phenotypes in human head and neck squamous cell carcinomas (HNSCC) with inflamed surrounding oral mucosal tissue and with peripheral blood immune cells, using flow cytometry, single cell transcriptomics, and the NicheNet ligand-receptor analysis tool for cell-cell interactions. First, they found tremendous congruence between immune cells in tumor tissues compared with cells in inflamed nontumor tissues. Second, they discovered that IL1R1 and the previously defined marker ICOS were almost exclusively induced on tumor-infiltrating regulatory T cells (Treg). Third, they found that IL1R1+ Tregs were highly suppressive. IL1R1 was induced on Tregs acutely, therefore its expression in tumors was likely a consequence of the high activation state of Tregs in tumors. Further, Tregs expressed high levels of the chemokine receptor CXCR6.... You do not currently have access to this content.