Metastasis Of Cutaneous Squamous Cell Carcinoma Research Articles

Sentinel Node Biopsy in Cutaneous Squamous Cell Carcinoma

Objective: In cases of cutaneous squamous cell carcinoma (SCCa), early detection of regional metastases can greatly improve survival. The objective of this study is to explore the utility of sentinel lymph node biopsy (SLNB) for early detection of regional metastasis in patients with high-risk cutaneous SCCa of the head and neck. Method: Participants include patients with cutaneous SCCa of the head and neck with high-risk prognostic features (size >2 cm, recurrence, depth >4-5 mm, poor differentiation, perineural invasion, history of CLL/SLL/organ transplantation) but no nodal metastases. All patients underwent excision of the primary tumor with SLNB. Specimens were analyzed for evidence of regional metastases. Results: Preliminary results include 19 patients who underwent excision of their tumor with SLNB, and 5 of 19 (26%) of these high-risk patients developed regionally metastatic disease. SLNB demonstrated a sensitivity of 80%. There was a SLNB false omission rate of 20%. Of the 5 patients with regional metastases, 1 (20%) demonstrated perineural invasion, 3 (60%) demonstrated lymphatic invasion, 3 (60%) demonstrated vascular invasion, 4 (80%) demonstrated poor differentiation, and all 5 (100%) demonstrated depth >4 mm. One case of false omission occurred in a patient with CLL. All patients are currently living, and 2 (40%) have developed regional recurrence. Conclusion: SLNB is capable of identifying early regional metastases in cutaneous SCCa. Preliminary data demonstrate that 26% of high-risk patients developed regional metastases. SLNB effectively identified 80% of metastatic disease, with a 20% false omission rate. Regional metastasis was most strongly associated with lymphovascular invasion, poor differentiation, and depth >4 mm.

Lymph Node Metastases from Cutaneous Squamous Cell Carcinoma of the Head and Neck

Cutaneous squamous cell carcinoma (CSCC) has been reported to metastasize to parotid and cervical lymph nodes. Few prospective investigations of associated clinical and histopathologic findings and their effect on patient outcomes exist. We seek to identify risk factors for nodal metastases in CSCC and determine the impact of lymphatic spread on survival and recurrence. Subset analysis of a prospective, longitudinal database of patients with CSCC at a comprehensive cancer center. Eligible patients with nonmelanoma skin cancer were consecutively enrolled in a prospective database from July 1996 through June 2001; this cohort was then followed to the key endpoints of recurrence and mortality. Two hundred ten patients were enrolled, and 193 patients with CSCC of the head and neck are included in this analysis. The incidence of nodal metastases in this population was 20.7% at study entry. Median follow-up was 20 months in patients with lymph node metastases and 24 months in patients without metastases. Nodal metastases were significantly associated with recurrent lesions (P = .002) and the following histopathologic features: lymphovascular invasion (P < .0001), inflammation (P = .010), poorly differentiated histology (P = .001), invasion into the subcutaneous tissues (P = .0001), perineural invasion (P = .005), and larger size (P = .0007). Metastases to the cervical nodes were not clinically apparent in 42% of patients with parotid metastases. Combination surgery and radiation therapy resulted in regional control rates of 95%, although local recurrence and distant metastases, along with second primary tumors, were the most frequent recurrent events. Kaplan-Meier survival analysis demonstrates a decrease in overall survival (P = .005), disease-free survival (P = .015), disease-specific survival (P = 0002), and time to recurrence (P = .012) in patients with nodal metastases compared with controls. Lymph node metastases from CSCC are common in our population and are associated with diminished survival. The presence of nodal spread occurs with other adverse histopathologic findings, and we recommend surgery and postoperative radiation therapy to control regional disease in the presence of nodal metastases and perineural invasion. New approaches in early identification of nodal metastases, treatment, and prevention of local recurrences and second primary malignancies are warranted.