Cutaneous Metastases Of Lung Cancer Research Articles

Cutaneous metastases of lung cancer.

Cutaneous metastases of lung cancer are rare. It was often painless and less likely to be noticed. Similar to SVC syndrome, cutaneous metastases may cause upper limb edema. We need to keep in mind that cutaneous metastases may account for the radiotherapy‐resistant upper limb edema.

Multiple cutaneous and intestinal metastases in lung cancer: A case report.

Lung cancer is a common malignant neoplasm that is prone to distant metastasis. However, the incidence of multiple cutaneous and intestinal metastases is rare. The present study describes the case of a 62-year-old female who was admitted to The Affiliated Hospital of Shandong Academy of Medical Sciences in August 2013 with multiple cutaneous lumps. Contrast-enhanced computed tomography showed nodules and masses in the right lung, and multiple enlarged lymph nodes in the mediastinum and right hilum. Biopsies of the lumps in the right lung and skin revealed moderately-differentiated adenocarcinoma, which were considered to be cutaneous metastases of lung cancer. The patient subsequently experienced symptoms of rectal irritation. A digital rectal examination and colonoscopy were performed, and the consequent pathological biopsy identified moderately-differentiated adenocarcinoma. After analyzing the results of previous pathological examinations and immunohistochemistry, it may be suggested that intestinal metastasis had developed. This case highlights the fact that a comprehensive analysis and examination should be performed for suspected cutaneous and intestinal lesions, during which, a pathological biopsy is of great importance in order to form the correct diagnosis for timely treatment.

When lung cancer is in the skin—A case report of a cutaneous metastasis of lung cancer

When lung cancer is in the skin—A case report of a cutaneous metastasis of lung cancer

Cutaneous metastasis as a initial presentation in advanced non-small cell lung cancer and its poor survival prognosis

Cutaneous metastases in primary advanced non-small cell lung cancer (NSCLC) rarely occur in comparison with other site involvement. The incidence of cutaneous metastases and its prognosis is not well known. Data from a 2,130 patients with advanced NSCLC were analyzed, in order to assess the incidence and survival prognosis of cutaneous metastases in primary advanced NSCLC. The clinical data of 2,130 patients with advanced NSCLC who were admitted to Zhejiang cancer Hospital from January 1998 to December 2007 were retrospectively analyzed. Data pertaining to their presentation, diagnosis treatment, pathology, follow-up, and clinical course were documented. Clinical characteristics were investigated based on the clinical and pathologic records. All of the cutaneous metastases were confirmed by cytology or biopsy. Survival analysis was made by Kaplan-Meier method. The Cox regression model was performed to analyze the relationship between the influential factors and the overall survival. Among the 2,130 advanced NSCLC patients as initial diagnosis, 60 (2.8 %) demonstrated abnormally cutaneous metastases. Fifteen patients with only cutaneous metastases, forty-five subjects combined with other site metastasis. There were 56 patients who received chemotherapy, and the first-line disease control rate was 33.9 %, the median free progression survival time was 1.9 months. There were significant differences in overall survival between cutaneous metastases and non-cutaneous metastases arms (3.9 vs. 10.0 months, P < 0.001). Multivariate analyses revealed that performance status and chemotherapy efficacy statistically associated with overall survival. This retrospective study indicated that 2.8 % of advanced NSCLC patients showed cutaneous metastases as an initial presentation. Cutaneous metastases of lung cancer are of poor prognosis.

A Case of Multiple Cutaneous Metastasis of Lung Cancer to the Finger

背景．原発性肺癌は多臓器に転移しやすい癌であり転移巣は多岐にわたる．その中で皮膚指尖部への転移は非常に稀である．症例．72歳男性．胸部CTで右S10に腫瘤影を指摘された．気管支内視鏡検査を施行し，肺扁平上皮癌と診断した（cT2N2M0 Stage IIIA）．初回化学療法としてcarboplatin+paclitaxelを4コース施行後，放射線療法を開始したが，治療経過中右第4，5指尖部に疼痛を伴う腫脹と発赤が出現し，同部位の穿刺細胞診を施行し，肺癌の転移と診断した．手指転移に対し放射線治療（30 Gy/10 Fr）を施行したが，除痛効果は認めたものの，病変部の壊死，自壊は進行し，他の指尖部にも同様の病変が出現した．2次化学療法としてdocetaxelを施行したが効果なく，その後原発巣の増大，多発皮下転移などが出現し，手指転移から3ヶ月で病死した．結語．肺癌の転移巣として稀な皮膚指尖部転移の症例を経験した．

Cutaneous metastasis of lung carcinoma: a retrospective study of 12 cases

The skin is a rare site of metastasis of the internal malignancies. On the contrary, lung cancer is a common primary malignancy of skin metastasis. The latter is either synchronous with the primary lung tumour or can reveal it. To analyse the clinical findings and the outcome of cutaneous metastasis in patients with primary lung cancer. Retrospective study including 12 cases of cutaneous metastasis of lung cancer diagnosed in our institution during 6years. Our patients included three women and nine men with a median age of 59.83years. The cutaneous metastases were unique in seven cases. They revealed the primary tumour in two cases, were discovered synchronously with the primary tumour in six cases and after the primary tumour in four cases. They appeared in patients presenting multiple metastases in 10 cases. Clinical appearance consisted on a firm nodule, sometimes ulcerated with a diameter ranging from 0.5 to 5.5cm. The tumour was sited in the thorax, the back, the abdomen; or the upper or lower limbs. Pathological examination of bronchial biopsy revealed an adenocarcinoma in eight cases, a squamous cell carcinoma in two cases and a small cell carcinoma in two cases. In spite of lung cancer therapies, the patients with metastasis to other organs with a median follow-up time of 4months died. Cutaneous metastases of lung cancer are of poor prognosis. They are most of the time associated with an advanced neoplastic process with metastasis to other organs. Median survival after skin involvement does not exceed months.

Cutaneous metastases of lung cancer

It is uncommon for a cancer to be diagnosed because of skin metastases. Cutaneous metastases as initial manifestation of internal neoplasias, represent only 0.8% of total cases and implies, in general, a very advanced grade of the disease and short survival. When skin metastases of an unknown primary site appear, lung cancer is the first option to be discarded in case of men, and breast cancer in case of women. Lung cancer spreads to the skin in 2.8-8.7% of the cases, in advanced phases of the disease, although just in 7-23.8% of the cases, cutaneous metastases appear as first manifestation of the primary tumor. Sometimes, a complete examination to discover the tumor reveals no metastases elsewhere.

Keratoacanthoma-like Cutaneous Metastasis of Lung Cancer: a Learning Point

A 58-year-old woman was admitted to our department with a tumour of the scalp. On admission, a 4 cm diameter, round, hard, red tumour with a central keratin plug was observed. During the 10-month period of development of the lesion no ulceration was seen within the tumour. The lesion clinically resembled keratoacanthoma (Fig. 1). Moreover, enlargement of the right supraclavicular lymph node was diagnosed. The patient has also suffered from psoriasis vulgaris, which had been treated in the past with topical agents, including tar preparations and phototherapy (narrowband UVB 311 nm). Moreover, she smoked more than 40 cigarettes per day for over 20 years. Biopsy of the skin lesion surprisingly revealed a metastatic carcinoma consisting of intermediate cells (Fig. 2A). The tumour cells were positive for epithelial membrane antigen (Fig. 2B), CAM 5.2 pancytokeratin marker (Fig. 2C) and chromogranin A (Fig. 2D). Moreover, metastases were also detected in the excised lymph node. Additionally, histological examination confirmed that the central plug consisted mainly of keratin and epithelial cells. On admission, routine laboratory examination revealed slight leukocytosis (10500/mm3), hyperglycaemia Keratoacanthoma-like Cutaneous Metastasis of Lung Cancer: a Learning Point

Cutaneous metastases of lung cancer.

The reported incidence of skin metastases from lung cancer varies from 2.8-7.5%. In the present study 8.7% of patients had skin metastases, with head and neck being the most common sites, nodular lesions the most common, and adenocarcinoma the most frequent histology. Although most patients develop these lesions during the course of a known progressive disease, they may be the presenting manifestation of a primary tumour in the lung. The occurrence of skin lesions in lung cancer announces an ominous prognosis. The response to chemotherapy is poor, possibly due to poor blood supply to the skin; monitoring response to chemotherapy, however, is easier when such lesions are present.