Cutaneous Laser Therapy Research Articles

Intraoperative Speckle Variance Optical Coherence Tomography for Tissue Temperature Monitoring During Cutaneous Laser Therapy.

Background: Tissue temperature monitoring during cutaneous laser therapy can lead to safer and more effective treatments. In this study, we investigate the use of speckle variance optical coherence tomography (svOCT) to monitor real-time temperature changes in the excised human skin tissue sample during laser irradiation. Methods: To accomplish this, we combined the pulse laser system with a reference-based svOCT system. To calibrate the svOCT, the ex-vivo human skin samples from three individuals with tissues collected from the arm, face, and back were heated with 1-degree increments. Additionally, linear regression was used to extract and evaluate the linear relationship between the temperature and normalized speckle variance value. Experiments were conducted on excised human skin sample to monitor the temperature change during laser therapy with a svOCT system. Thermal modeling of ex-vivo human skin was used to numerically simulate the laser-tissue interaction and estimate the thermal diffusion and peak temperature of the tissue during the laser treatment. Results and Conclusion: These results showed that normalized speckle variance had a linear relationship with the tissue temperature before the onset of tissue coagulation (52°) and we were able to measure the rapid increase of the tissue temperature during laser therapy. The result of the experiment is also in good agreement with the numerical simulation result that estimated the laser-induced peak temperature and thermal relaxation time.

Future Directions in Cutaneous Laser Surgery

This article presents an overview of future trends in cutaneous laser therapy and technology. To enhance efficacy and specificity of treatment, new wavelengths directed at both old and new targets are on the horizon. New applications, including the use of lasers to aid in the detection of skin cancers and to enhance drug delivery, are being used and investigated. A trend toward combining different lasers and light sources to optimize results continues. Advancements in at-home devices have been made. Future applications will include waveforms beyond those in the visible light and infrared spectrum, such as microwaves, ultrasound waves, and radiofrequency.

Update on cutaneous laser therapy: recent medical advances of laser light and skin interactions

The introduction of the theory of selective photothermolysis has brought to medicine an entirely new therapeutic modality for treating cutaneous disorders. With ongoing research into existing therapies, cutaneous laser medicine is experiencing an expansion in application and safety profiles for many existing technologies. Additional trials and reports have also deepened our understanding and broadened our use for many existing cutaneous laser applications, such as for the treatment of pigment disorders, scarring, vascular disorders and noninvasive removal of fat. Recent data has demonstrated a valuable role of combined pharmacologic and laser modalities for the treatment of vascular malformations. This article will review recent developments of cutaneous laser science and technologies over the last several years, including such innovations as fractional photothermolysis and cryolipolysis.

Laser Surgery in Dark Skin

Although challenging, effective laser surgery in patients with darker skin tones can be achieved despite a higher inherent risk of side effects. Although the incidence of undesirable postoperative sequelae has decreased with the development of advanced laser technology and individualized treatment parameters, these risks may never be eliminated completely. Consequently, thorough patient preoperative preparation and education regarding the risks of cutaneous laser therapy will remain an essential component of treatment in darkly pigmented patients. In the future, as more refined laser techniques evolve, the ability to safely and effectively treat these patients will improve.

Use of Onion Extract, Heparin, Allantoin Gel in Prevention of Scarring in Chinese Patients Having Laser Removal of Tattoos: A Prospective Randomized Controlled Trial

With rapid advancement in cutaneous laser therapy, Q-switched lasers have become the standard treatment for tattoo removal. The longer wavelength Q-switched Nd:YAG laser is used when removing tattoos in darker skin patients to avoid scarring and permanent pigment changes. Nevertheless, the local experience revealed that nearly 25% of the Chinese patients developed scarring. Meanwhile, multiple clinical studies have shown that Contractubex gel (Merz Pharma, Frankfurt, Germany) was effective in the treatment and prevention of hypertrophic scars and keloids. To evaluate the efficacy of Contractubex gel in the prevention of scarring after laser removal of tattoos in Chinese patients. A total of 120 Chinese patients with 144 professional blue-black tattoos were recruited into the study. They were randomly assigned into the Contractubex group or the control group. All patients were treated with a QS 1,064-nm Nd:YAG laser using a 3-mm spot size, a 10-Hz repeat rate, a pulse duration of 6 nanoseconds, and fluences that ranged from 3.6 to 4.8 J/cm2 (mean fluence, 4.2 J/cm2). The treated areas were assessed 3 months after the last treatments for clinical clearance and complications. Fifty-two patients with 61 tattoos in the Contractubex group were able to achieve a mean clearing rate of 82.3+/-11.6%. There were 7 tattoos in 7 patients that developed scarring, 4 patients had permanent hypopigmentation, and 3 patients had transient hyperpigmentation. In contrast, 55 patients with 68 tattoos in the control group had a mean clearing rate of 80.4+/-11.3%. Among them, 16 tattoos in 14 patients developed scarring, 4 patients had permanent hypopigmentation, and 5 patients had transient hyperpigmentation. Although there was no significant difference in age, sex, fluence, treatment session, and clinical clearance between the two groups, the Contractubex group had a statistically significantly lower rate of scarring than the control group (p<.05). Contractubex gel is effective in scar prevention in Chinese patients having laser removal of tattoos.

Cutaneous laser therapy. Principles and methods. K.A. Arndt, J.M. Noe and S. Rosen. 235 × 155 mm. Pp. 241 + xiii. Illustrated. 1983. Chichester: John Wiley &amp; Sons. £24.00

Cutaneous laser therapy. Principles and methods. K.A. Arndt, J.M. Noe and S. Rosen. 235 × 155 mm. Pp. 241 + xiii. Illustrated. 1983. Chichester: John Wiley &amp; Sons. £24.00

Laser surgery in dark skin.

Although challenging, effective laser surgery in patients with darker skin tones can be achieved despite a higher inherent risk of untoward side effects. While the incidence of undesirable postoperative sequelae has decreased with the development of advanced laser technology and individualized treatment parameters, these risks may never be eliminated completely. Consequently, thorough patient preoperative preparation and education regarding the risks of cutaneous laser therapy will remain an essential component of treatment in darkly pigmented patients. In the future, as more refined laser techniques evolve, the ability to safely and effectively treat these patients will improve.

Laser-induced weal and flare reactions: clinical aspects and pharmacological modulation.

Among the adverse effects of cutaneous laser therapy, weal and flare reactions immediately after treatment have received little attention, and the pathomechanisms are unclear. To study clinical features and possible mechanisms of laser-induced weal and flare reactions in order to identify means of possible therapeutic intervention. Normal skin from the inner arm of 20 volunteers was treated with an argon laser, and the size of weal and flare reactions was measured over a 60-min period. Skin biopsies were taken from four volunteers before and up to 24 h after laser treatment and examined histologically and immunohistologically. Possible underlying mechanisms were also explored using various topical or systemic pharmacological agents. Wealing was noted in 19 of 20, and flare reactions in all volunteers, with peak values at 15 min. Skin biopsies showed central coagulation of the tissue, cleft formation between epidermis and dermis, normal numbers of morphologically intact mast cells on toluidine blue staining close to the lesion, and only minor upregulation of endothelial and leucocyte adhesion molecules. In agreement with these findings, pretreatment with acetylsalicylic acid, the H1-blocker loratadine and triamcinolone cream was ineffective or resulted in a non-significant reduction of weal and flare reactions. In contrast, local anaesthetics as well as neuropeptide depletion of skin with capsaicin abolished the reactions almost completely. Transient weal and flare reactions in response to laser treatment occur in almost all persons and are based primarily on a neurogenic rather than a histamine- or mast cell-dependent mechanism.

Anesthesia for cutaneous laser therapy

Anesthesia for cutaneous laser therapy

Cutaneous Laser Therapy: Principles and Methods edited by K. A. Arndt, G. M. Noe, and S. Rosen

<i>Cutaneous Laser Therapy: Principles and Methods</i> edited by K. A. Arndt, G. M. Noe, and S. Rosen

Cutaneous Laser Therapy— Principles and Methods

Cutaneous Laser Therapy— Principles and Methods

Book Reviews

British Journal of DermatologyVolume 110, Issue 3 p. 381-383 Book Reviews First published: March 1984 https://doi.org/10.1111/j.1365-2133.1984.tb04650.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Cutaneous Infestations of Man and Animal. Edited by L.C.Parish, W.B.Nutting and R.M.Schwartzman Contact and Photocontact Allergens, a Manual of Predictive Test Methods. By Thomas Maurer Technical Guide for Smear Examination for Leprosy by Direct Microscopy. By D.L.Leiker and A.C.McDougall Cutaneous Laser Therapy: Principles and Methods. Edited by K.A.Arndt, J.M.Noe and S.Rosen Volume110, Issue3March 1984Pages 381-383 RelatedInformation