Abstract
Background: Tissue temperature monitoring during cutaneous laser therapy can lead to safer and more effective treatments. In this study, we investigate the use of speckle variance optical coherence tomography (svOCT) to monitor real-time temperature changes in the excised human skin tissue sample during laser irradiation. Methods: To accomplish this, we combined the pulse laser system with a reference-based svOCT system. To calibrate the svOCT, the ex-vivo human skin samples from three individuals with tissues collected from the arm, face, and back were heated with 1-degree increments. Additionally, linear regression was used to extract and evaluate the linear relationship between the temperature and normalized speckle variance value. Experiments were conducted on excised human skin sample to monitor the temperature change during laser therapy with a svOCT system. Thermal modeling of ex-vivo human skin was used to numerically simulate the laser-tissue interaction and estimate the thermal diffusion and peak temperature of the tissue during the laser treatment. Results and Conclusion: These results showed that normalized speckle variance had a linear relationship with the tissue temperature before the onset of tissue coagulation (52°) and we were able to measure the rapid increase of the tissue temperature during laser therapy. The result of the experiment is also in good agreement with the numerical simulation result that estimated the laser-induced peak temperature and thermal relaxation time.
Highlights
Cutaneous laser therapy has been widely used to treat skin conditions such as port wine stains, acne scars, photodamage, and wrinkles over the past 40 years [1]
Our results showed that speckle variance optical coherence tomography (svOCT) can be used to accurately and safely analyze the change in tissue temperature during the pulse laser irradiation
The calibration result showed that the normalized speckle variance had a linear relationship with the tissue temperature until the onset of tissue coagulation (52◦)
Summary
Cutaneous laser therapy has been widely used to treat skin conditions such as port wine stains, acne scars, photodamage, and wrinkles over the past 40 years [1]. Given that laser operators have widely varying degrees of competence and training, more objective measures of laser-tissue interaction would allow for safer and more efficacious treatments. Tissue temperature monitoring during cutaneous laser therapy can lead to safer and more effective treatments. We investigate the use of speckle variance optical coherence tomography (svOCT) to monitor real-time temperature changes in the excised human skin tissue sample during laser irradiation. To calibrate the svOCT, the ex-vivo human skin samples from three individuals with tissues collected from the arm, face, and back were heated with 1-degree increments. Experiments were conducted on excised human skin sample to monitor the temperature change during laser therapy with a svOCT system. Thermal modeling of ex-vivo human skin was used to numerically simulate the laser-tissue interaction and estimate the thermal diffusion and peak temperature of the tissue during the laser treatment. The result of the experiment is in good agreement with the numerical simulation result that estimated the laser-induced peak temperature and thermal relaxation time
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