Cutaneous Crohn's Disease Research Articles

Treatment of cutaneous Crohn’s disease with infliximab

Purpose: Cutaneous or metastatic Crohn's disease is extremely rare. Treatment to this date has been sub optimal, but normally consists of steroids, immunosuppression, and occasionally intralesional injection of steroids. We present a case of cutaneous Crohn's disease that was successfully treated with Infliximab.

Manifestations métastatiques cutanées de la maladie de Crohn

Introduction. – Cutaneous metastatic Crohn's disease is a granulomatous inflammation of the skin that is noncontiguous to the gastrointestinal tract. Case Report. – A 42-year-old man with Crohn's disease is admitted for antibiotic resistant erysipela-like dermo-hypodermitis. The presence of granulomatous lesions on skin biopsy, the absence of any infectious agent identified despite extensive investigations and the dramatic improvement observed with corticosteroid eventually lead to the diagnosis of cutaneous metastatic Crohn's disease. Conclusion. – During Crohn's disease, biopsy should be considered for every undiagnosed skin lesion as the characteristics of cutaneous metastatic Crohn's disease are not specific. The presence of a non caseous granulomatous dermal infiltration suggests the diagnosis and should make consider the initiation of corticosteroid and the discontinuation of others inappropriate therapeutics (i.e. surgical treatment, antibiotics).

Granulomatous and suppurative dermatitis at interferon alfa injection sites: Report of 2 cases

It has previously been reported that interferon alfa injection sites may develop pyoderma gangrenosum, interface dermatitis, vasculitis, or, more commonly, ulcers characterized by intravascular thrombi and a mixed inflammatory cell infiltrate. We describe 2 patients in whom granulomatous and suppurative dermatitis developed at interferon alfa injection sites. These cases extend the spectrum of interferon alfa injection site reactions. The histologic and clinical similarities of these cases with pyoderma gangrenosum and cutaneous Crohn's disease are explored. (J Am Acad Dermatol 2002;46:611-6.)

Crohn's disease presenting as a breast abscess: A case report

A case of cutaneous Crohn's disease (CD) involving the areola-nipple region of both breasts in a 45-year-old woman is reported. The lesion had initially been diagnosed and treated as a simple abscess. Histopathological examination, however, showed granulomatous inflammation with eosinophils suggesting extraintestinal CD. The patient also had a minor area of cutaneous CD localized at the umbilicus and severe anogenital lesions. Twenty-six years previously the woman had undergone a course of sulphasalazine treatment together with steroid enema for chronic inflammatory colitis, but the colitis had been inactive for 25 years. Treatment with sulphasalazine, metronidazole, prednisolone and azothioprine had only minor effect on the skin lesions. CD is a systemic disorder and the most prominent manifestations may be extraintestinal.

Cutaneous Crohn's disease in children

Although cutaneous Crohn's disease is well recognized in adults, in children it is extremely rare. Our purpose was to describe five children with cutaneous Crohn's disease and to review the literature. The medical records of five children with cutaneous Crohn's disease were retrospectively reviewed for clinical features and laboratory data. An extensive review of the literature was conducted. Five children, one boy and four girls, 6 to 12 years of age at onset, had cutaneous manifestations of Crohn's disease. Three had genital swelling, and the other 2 had buttock abscesses. Most were seen before the diagnosis of gastrointestinal Crohn's disease was made. There have been 80 cases of cutaneous Crohn's disease described, including our series. Only 14 were in children. Two thirds of children with cutaneous Crohn's disease had genital involvement compared with about half of the adult cases. Sixteen of the 80 patients had cutaneous lesions without preceding gastrointestinal Crohn's disease. Of these, approximately 70% had genital lesions. Although Crohn's disease is common in children, cutaneous manifestations are rarely a presenting sign. However, when cutaneous Crohn's disease is present in children, it commonly precedes the gastrointestinal disease.

Cutaneous Crohn's disease responsive to cyclosporin A

Cutaneous Crohn's disease responsive to cyclosporin A

Granulomatous Vaginal Ulceration due to Metastatic Cutaneous Crohn's Disease

A 28-year-old woman with a prior history of Crohn's disease was evaluated for painful vaginal ulceration in 1984. Subsequent studies revealed isolated involvement of the vagina with a granulomatous inflammatory process characteristic of metastatic cutaneous Crohn's disease. Conservative symptomatic treatment was associated with resolution and no subsequent recurrence of genital tract disease.

Immunocompetent cells and adhesions molecule expression in cutaneous granulomatous Crohn's disease

Immunocompetent cells and adhesions molecule expression in cutaneous granulomatous Crohn's disease

Cutaneous polyarteritis nodosa and Crohn's disease

We report a case of a 57-year-old woman who presented simultaneously cutaneous polyarteritis nodosa and Crohn's disease of the colon. Although similar pathogenic hypotheses have been reported, the association of both diseases is exceptional.

Multicentric Cutaneous Crohn's Disease: A Case Report and Review of Literature

A patient presented with skin lesions at sites not contiguous with Crohn's disease of the bowel and with specific histological features of Crohn's disease occurring two weeks from the onset of bowel symptoms. Currently a number of nonspecific skin conditions such as erythema nodosum, pyoderma gangrenosum and erythema multiforme are accepted as being the most common skin manifestations of Crohn's disease. It is likely, however, that specific lesions of Crohn's disease in the skin have been underdiagnosed either because of lack of biopsy or misinterpretation of the histology. Twenty-three cases with specific Crohn's disease in the skin have been recorded in the past 25 years, since the condition has been recognized. Sarcoidosis has been a common misdiagnosis. The literature relating to multicentric Crohn's disease is reviewed and attention drawn to its protean and masquerading features. An argument is made for the use of the term 'multicentric' rather than 'metastatic' in relation to cutaneous Crohn's disease.

Healing of severe perineal and cutaneous Crohn's disease with hyperbaric oxygen

Recurrent perineal Crohn's disease can be an extremely debilitating complication that may be difficult to treat. We report a patient with progressively worsening perineal and biopsy-proven cutaneous Crohn's disease that had been refractory to surgery and medical treatment (sulfasalazine, steroids, 6-mercaptopurine, metronidazole, antibiotics). As the lesions were reminiscent of problem wounds occurring in other situations, hyperbaric oxygen treatment was instituted while the patient was continued on metronidazole. Response was dramatic with almost immediate relief of symptoms and regression within 2.5 mo of wounds that had previously defied therapy for 8 yr. Clinical remission has not been sustained as four subsequent courses of hyperbaric oxygen have been given over a period of 11 mo. However, the patient has been essentially asymptomatic since her initial course and the extent of her cutaneous disease has been minimal compared with that before hyperbaric oxygen. Hyperbaric oxygen treatment is costly and should not be routinely used in every patient with perineal Crohn's disease. However, this case report may herald an advance in the understanding of the pathogenesis of this complication and ultimately, its therapy.

Cutaneous Crohn's disease and progressive vitiligo

A patient with Crohn's colitis rapidly developed violaceous papules and plaques on the thigh, breast, and back during an exacerbation of colitis. Biopsy specimens of lesional bowel and skin showed noncaseating granulomatous inflammation consistent with Crohn's disease. The rare occurrence of granulomatous skin lesions widely separated from the perirectal area, previously reported as metastatic Crohn's disease, is reviewed, and the additional finding of concomitant vitiligo with a possible linked pathogenesis is briefly discussed.

(32) Cutaneous Crohn's disease

British Journal of DermatologyVolume 115, Issue s30 p. 79-80 (32) Cutaneous Crohn's disease Drs S.E. Thomas, Drs S.E. ThomasSearch for more papers by this authorR.E. Church, R.E. ChurchSearch for more papers by this author Drs S.E. Thomas, Drs S.E. ThomasSearch for more papers by this authorR.E. Church, R.E. ChurchSearch for more papers by this author First published: July 1986 https://doi.org/10.1111/j.1365-2133.1986.tb07727.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume115, Issues30July 1986Pages 79-80 RelatedInformation

Widespread Cutaneous Crohn's Disease Presenting in Childhood

Summary:Cutaneous lesions containing Crohn's granulomata are rare and tend to occur in submammary or abdominal wall skin folds when they are to be found (1). Crohn's disease of the skin in nonflexural locations has been reported (2,3) although not in children. We report a 5‐year‐old girl with extensive colonic Crohn's disease, who at presentation was noted to have a generalised erythematous papular rash which histologically showed typical noncaseating granulomata.

(32) Extensive cutaneous Crohn's disease

(32) Extensive cutaneous Crohn's disease

(32) Extensive cutaneous Crohn's disease

(32) Extensive cutaneous Crohn's disease

Cutaneous polyarteritis nodosa. Report of a case associated with Crohn's disease

A patient had cutaneous polyarteritis nodosa associated with Crohn's disease. Immunopathologic studies disclosed evidence of circulating immune complexes as measured by C1q binding. Immunofluorescent microscopy of lesional skin showed C3 and fibrin deposition. Histamine injection of normal skin and subsequent biopsy specimens and immunofluorescent microscopy showed immune deposits. The patient was treated with cyclophosphamide and prednisone with a good clinical response, but within two years, histiocytic lymphoma developed. There is an association of cutaneous polyarteritis and Crohn's disease, and also, immunosuppressive therapy plays a role in the development of histiocytic lymphoma.

Cutaneous Polyarteritis Nodosa

A patient had cutaneous polyarteritis nodosa associated with Crohn's disease. Immunopathologic studies disclosed evidence of circulating immune complexes as measured by C1q binding. Immunofluorescent microscopy of lesional skin showed C3 and fibrin deposition. Histamine injection of normal skin and subsequent biopsy specimens and immunofluorescent microscopy showed immune deposits. The patient was treated with cyclophosphamide and prednisone with a good clinical response, but within two years, histiocytic lymphoma developed. There is an association of cutaneous polyarteritis and Crohn's disease, and also, immunosuppressive therapy plays a role in the development of histiocytic lymphoma.