Cutaneous Bleeding Research Articles

PURPURA HEMORRHAGICA FOLLOWING SULPHARSPHENAMINE

During the last few years, from time to time, cases have appeared in medical literature, presenting a blood picture suggestive of an aplastic pernicious anemia with cutaneous hemorrhages and no apparent visceral changes following treatment with neoarsphenamine and sulpharsphenamine, particularly, the former. Every one who has treated many patients with syphilis has occasionally been unfortunate enough to have had a toxic effect of medication with cutaneous manifestations. I am reporting the first hemorrhagic case which I have observed, after approximately four thousand injections of the arsphenamines. Its exceptional severity and unusual character, coupled with several points of particular interest, seem sufficient to warrant a brief report and discussion. REPORT OF CASE History.— A B., a man, aged 54, married, was sent to me in the summer of 1925 with definite physical signs of beginning tabes dorsalis. The Wassermann reaction was four plus to both alcoholic and cholesterinized antigens in the

A CASE OF TYPHOID FEVER WITH AN UNUSUAL COMPLICATION.

Hemorrhage as a complication of typhoid fever presents some interesting phases. The literature on the subject of enteric fever abounds with discussions of hemorrhage from almost every organ in the body, but the uterus seems to have been overlooked. In the literature at my command I have been able to find but very little. By most authorities on the subject no mention whatever is made of uterine hemorrhage as a complicacation of typhoid fever. Osler, however, does mention "a rare and fatal form of typhoid fever characterized by cutaneous and mucous hemorrhages." Montgomery, in his work on gynecology, draws attention to the fact that "severe uterine hemorrhage may frequently usher in an attack of typhoid fever," and this is not uncommon, especially if it happens to be about the time of the normal menstrual flow. In the case, however, presented here for your consideration, the hemorrhage did not usher