Cutaneous Angiomyolipoma Research Articles

Unusual presentation of cutaneous angiomyolipoma in the umbilical region: A case report

Background: Cutaneous angiomyolipoma (CAML) is a rare benign tumour originating from the perivascular cells of the smooth muscle and fat. Owing to its rarity, clinical presentation, size, and location, we report a case of interest. Case report: A 59-years-old male patient from the Etawah district presented with a lump in the anterior abdominal wall of the umbilical region for the past 5 months. The patient was asymptomatic, but was concerned about the nature of the lump and agreed to undergo excision of the lump, which revealed angiomyolipoma of the anterior abdominal wall on histopathological examination. The patient experienced no complications from the excision and was discharged from the hospital. This particular subsite is rare and lacks association with tuberous sclerosis, a clinical entity commonly associated with renal angiomyolipoma Conclusion: The final diagnosis was confirmed by histopathology based on the traditional criteria of the presence of blood vessels, fat tissue, and smooth muscles. Surgery is the preferred course of treatment, and complete resection is important because incomplete resection may cause recurrence. Keywords: benign; smooth muscle; tumor; blood vessel; adipose tissue

Cutaneous Angiomyolipoma (Angiolipoleiomyoma): Case Report and Review of Literature with Emphasis on Nomenclature

Abstract Introduction/Objective Cutaneous angiomyolipomas (AML) are rare lesions that have morphological similarities to renal AML, but appear to be biologically distinct. Methods/Case Report We report the case of a 69-year-old man who presented with a slowly enlarging nodule on the dorsum of the right hand that was painful upon wrist flexion and is slightly tender to palpation. A ganglion cyst was clinically suspected, and the lesion was excised. Microscopically, this was a well-circumscribed nodule with a thin fibrous capsule that was highlighted by a trichrome stain. The lesion was composed of thick-walled blood vessels surrounded by bundles of smooth muscles that intermingled with adipose tissue. Smooth muscle actin immunostain highlighted the smooth muscles, but HMB-45 was negative. There was no atypia, and no mitoses. A diagnosis of “cutaneous angiomyolipoma” was made. Results (if a Case Study enter NA) NA Conclusion A review of the limited number of published cases showed that unlike renal AML, this lesion is not associated with tuberous sclerosis, is negative for melanocytic markers, and shows male-predominance, suggesting that the two morphologically similar lesions are biologically unrelated. The 2018 WHO classification of skin Tumors does not list this entity, so nomenclature is not standardized. Some authors suggested that these are simply angioleiomyomas with prominent adipose tissue, but the female predominance of angioleiomyoma makes this unlikely. Others have recognized this as a distinct entity and described it as an “angiolipoleiomyoma”, to distinguish it from renal AML. We now advocate for the latter approach to avoid confusion with renal AML. Otherwise, the prefix of “cutaneous” should always be used in the diagnosis to highlight this distinction.

Comment on "Cutaneous Angiomyolipoma of the Ear: A Case Report and Literature Review" With Report of a Mucosal Lesion.

Comment on "Cutaneous Angiomyolipoma of the Ear: A Case Report and Literature Review" With Report of a Mucosal Lesion.

皮肤血管平滑肌脂肪瘤一例

A cutaneous angiomyolipoma, which is also known as a cutaneous angiolipoleiomyoma, is a rare benign mesenchymal tumor. Only 18 cases have been reported in the English literature. We describe a case of an angiomyolipoma presenting on the right ear helix of a 26-year-old female. The histopathologic examination revealed a typical form of an angiomyolipoma with a proliferation of mature adipocytes. As with all previously reported cases, our patient did not present with the stigmata of tuberous sclerosis. This is the 20th reported case of cutaneous angiomyolipoma and the 3rd reported case in Korea.

Cutaneous Angiomyolipoma of the Nose

Angiomyolipomas (AML) are benign mesenchymal tumours. It is commonly seen in the kidney. Extra-renal sites of AML are uncommon though it can occur in any part of the body. Reports of cutaneous AML are rare in the literature. We present a case of an 11-year-old female with a polypoidal swelling on the nose that was noticed a few weeks after birth, which progressively increased in size till it was causing nasal blockage. This cutaneous lesion is different from a renal angiomyolipoma because it lacks features of tuberous sclerosis, non-invasive, absence of epithelioid cells and negative HMB-45 staining. Histopathology shows a mixture of blood vessels, mature adipocytes and smooth muscle. These unique features distinguish this lesion from other possible differentials such as angiomyoma and myolipoma. Histopathology and immunohistochemistry confirm the swelling as angiomyolipoma of the nose. We concluded that histopathology and immunohistochemistry are important diagnostic tools for cutaneous AML irrespective of gender, age of onset and site of lesion.

A cutaneous angiomyolipoma case mistaken for a parotid mass

Angiomyolipoma is a benign tumor consisting of vascular structures, smooth muscle and adipose tissue. It is most commonly found in the kidney and more infrequently in the liver, lung, heart, intestines, nasal cavity, oral cavity and ear. Cutaneous angiomyolipomas are very rare and show some differences with non-cutaneous angiomyolipomas, these are mostly located in the distal extremities and due to trauma, HMB-45 antibody negativity and appear more frequently in men. All cases except one presented until today were observed not to have cellular atypia; thus, cutaneous angiomyolipomas are considered not to perform malign transformation. It is thought that total excision of the mass is adequate in treatment of cutaneous angiomyolipoma. Our case applied to our clinic with a left preauricular mass which was thought to be a parotid mass after initial physical examination. After magnetic resonance imaging (MRI) scan was performed, it was seen that the mass did not originate from parotid gland After the FNAC resulted non-diagnostic, the mass was excised. Pathological examination revealed "angiomyolipoma" diagnosis.

Angiomyolipoma of the Glabellar Region.

Angiomyolipomas are hamartomatous lesions consisting of smooth muscle bundles, thick-walled blood vessels, and mature adipocytes. They are usually found in the kidneys of tuberous sclerosis patients and more rarely in other organs, such as the liver, the oral cavity, the sinonasal tract, the heart, the large intestines, the lungs, and the skin. Cutaneous angiomyolipoma has shown to be very rare and generally occurs at the ends of the digits, the elbows, the ears, and the nose. Herein, we report the first documented case of angiomyolipoma of the glabellar region.

To the editor: Is this cutaneous angiomyolipoma truly an angiomyolipoma?

To the editor: Is this cutaneous angiomyolipoma truly an angiomyolipoma?

Cutaneous angiomyolipoma

Cutaneous angiomyolipoma

Cutaneous angiomyolipoma: report of a case

患者女,50岁.左前臂包块20余年于2010年4月入院.包块近年渐增大,无明显不适,表面皮肤无异常改变,肿块无压痛,可推动.临床诊断为脂肪瘤,遂行脂肪瘤切除术.术中见肿块位于皮下,与周围组织分界清楚,易剔除,表皮未见累及。

Cutaneous angiomyolipoma

We report a case of cutaneous angiomyolipoma (AML) found on the anterior abdominal wall of a 3-year-old female child. Histologic examination showed a well-circumscribed nodule in the dermis composed of an intimate mixture of convoluted thick-walled blood vessels, smooth muscle, and mature fat. This lesion differs from renal AML in terms of a lack of association with tuberous sclerosis, circumscription, absence of epithelioid cells, and male predominance. We concluded that the unique features of this lesion distinguish it from other lesions such as angiomyoma, angiolipoma, myolipoma, haemangioma, and other mixed mesenchymal tumors. This case report suggests that the features considered diagnostic of AML can occur in extrarenal sites and, therefore, this diagnosis cannot be excluded on the basis of site alone.

Case of a cutaneous angiomyolipoma in the ear

Case of a cutaneous angiomyolipoma in the ear

Cutaneous angiomyolipoma

Cutaneous angiomyolipomas are rare. We report a case in a 45-year-old male with a well circumscribed lesion located on the chin. This lesion, probably hamartomatous in nature, differs from renal angiomyolipoma in terms of nonassociation with tuberous sclerosis, circumscription, and male predominance. Another characteristic feature is the absence of epithelioid cells. Differential diagnosis includes angiolipoma, angioleiomyoma, hemangioma, and myolipoma. It is distinguished from the abovementioned entities by the presence of a combination of thick-walled blood vessels, smooth muscle, and fat.

A Case of a Cutaneous Angiomyolipoma

A cutaneous angiomyolipoma, which is also known as a cutaneous angiolipoleiomyoma, is a rare benign mesenchymal tumor. Only 18 cases have been reported in the English literature. We describe a case of an angiomyolipoma presenting on the right ear helix of a 26-year-old female. The histopathologic examination revealed a typical form of an angiomyolipoma with a proliferation of mature adipocytes. As with all previously reported cases, our patient did not present with the stigmata of tuberous sclerosis. This is the 20th reported case of cutaneous angiomyolipoma and the 3rd reported case in Korea.

The Revision of the Article Entitled "A Case of a Cutaneous Angiomyolipoma"

Dear Editor, We have read the article entitled A Case of a Cutaneous Angiomyolipoma by Shin et al1. The author informs that This article is the 20th reported case of cutaneous angiomyolipoma and the 3rd reported case in However, Ko et al2 had reported a case of cutaneous angiomyolipoma in Korean Journal of Dermatology and accordingly, the case in the article of Shin et al1 becomes the 4th reported case in Korea. In addition, the illustration of the figure describing a blue nodule in the left ear does not correspond with the text which describes it as the right ear and should be revised correctly. It will be very pleasing if we could acquire more accurate and valuable information from Annals of Dermatology in the future.

Management of cutaneous angiomyolipoma and its association with tuberous sclerosis

Although typically presenting renally, angiomyolipomas can rarely present in the skin. The tumors are composed of an admixture of blood vessels, smooth muscle and adipose tissue and are often seen in the setting of tuberous sclerosis. We describe a case of angiomyolipoma presenting on the thigh of a 50-year-old white female. This is the 17th reported case of cutaneous angiomyolipoma. As with all previously described cases, our patient did not present with the stigmata of tuberous sclerosis. Angiomyolipoma should be considered within the differential for subcutaneous nodules and work-up for tuberous sclerosis should not be pursued when presenting in the skin.

Cutaneous angiolipoleiomyoma

We describe a girl with cutaneous angiolipoleiomyoma on the buttock. The 16-year-old girl had a 2.5- x 1.5-cm subcutaneous tumor on the right buttock, which was slightly tender. The tumor appeared to be vascular and was, therefore, surgically excised. Histologically, the lesion was poorly circumscribed and was composed of differently sized blood vessels, smooth-muscle bundles, and mature adipose tissue. These histologic findings were consistent with those of angiomyolipoma, which commonly occurs in the kidney. Cutaneous angiomyolipoma, which is also known as cutaneous angiolipoleiomyoma, is a rare benign mesenchymal tumor. To our knowledge, only 16 cases have been reported in the English-language literature. In our report, we review the clinical features of 17 cases, including the current one. We point out the differences between the cutaneous and renal forms of angiomyolipoma, and conclude that the cutaneous lesion is distinct from a renal lesion in several aspects, including tuberous sclerosis complex association and immunoreactivity to both HMB-45 and MART-1.

Cutaneous Angiomyolipoma

Cutaneous Angiomyolipoma

Cutaneous Angiomyolipomas are HMB45 Negative, Not Associated with Tuberous Sclerosis, and Should Be Considered as Angioleiomyomas with Fat

Angiomyolipomas are uncommon tumors in the skin. Neoplasms with the same name are more typically associated with a renal location, many in the context of tuberous sclerosis. Three cases of cutaneous angiomyolipoma are reported, which were all HMB45 negative and not associated with tuberous sclerosis. This is the first series of such tumors to be stained with HMB45. The presence of fat in histologically similar cutaneous angioleiomyomas has been previously documented and a review of 40 archival cases revealed fat in 1 case. The author proposes that cutaneous angiomyolipomas should be termed angioleiomyoma with fat to avoid confusion with unrelated non-cutaneous angiomyolipomas that are HMB45 negative and require investigation for tuberous sclerosis.

Cutaneous angiomyolipoma: report of two cases with emphasis on HMB-45 utility

Background Angiomyolipomas are tumors composed of adipose tissue, blood vessels and smooth muscle. Although renal angiomyolipomas are well known, cutaneous tumors have been described only recently. HMB-45 reactivity, reported for renal angiomyolipomas, has been suggested as a useful tool in differential diagnosis.Objective Two cases of cutaneous angiomyolipoma are described and investigated for HMB-45 reactivity.Methods Conventional histochemical and immunohistochemical methods were used.Results Immunohistochemical analysis showed no reactivity for HMB-45 antibody.Conclusion We conclude that, unlike renal angiomyolipomas, HMB-45 reactivity is not helpful in differentiating cutaneous angiomyolipomas.