In this paper, motivated by [13], we use the Littlewood-Paley theory to investigate the Cauchy problem of the Boltzmann equation. When the initial data is a small perturbation of an equilibrium state, under the Grad's angular cutoff assumption, we obtain the unique global strong solution to the Boltzmann equation for the hard potential case in the Chemin-Lerner type spaces $C([0,\infty);\widetilde{L}^{2}_{\xi}(B_{2,r}^{s}))$ with $1\leq r\leq2$ and $s>3/2$ or $s=3/2$ and $r=1$. Besides, we also prove the Lipschitz continuity of the solution map. Our results extend some previous works on the Boltzmann equation in Sobolev spaces.