AbstractElectronic skins (E‐skins), which are intelligent extensions of the human skin, are in great demand because of the rapid development of information technology and intelligence in human civilization. Essentially, E‐skin systems are composed of functional and interface components. The function portion carries out various functions like sensing, power production, and therapy. In addition to ensuring consistent wear and comfort, the interface of the E‐skin system is necessary for the transfer of energy or mass between the skin and the functional components of the E‐skin system. The interface serves as the foundation, conduit, and link between the skin and functional components of E‐skin systems. The wearability and functionality of the E‐skin system are significantly impacted by the interfacial adhesion and the intermediate effect. It is crucial to build the interface in accordance with the functions of the E‐skin system. However, there are few reviews on the impact of the interface on the functionality and wearability of E‐skins. Here, the design of the E‐skin interface is thoroughly reviewed, taking into account how skin adhesion mechanisms affect wearability and function. At last, the future development direction and perspective of next‐generation E‐skin systems are presented.