This analysis uses the Levenberg-Marquardt back propagation artificial neural networks (LM-BP-ANNs) approach to demonstrate the mathematical strategy of neural networks for the simulation of MHD Tangent hyperbolic nanofluid (THNF) flow consisting of motile microorganisms through a vertically extending surface. The fluid flow is being investigated in terms of exponential heat source/sink, thermal radiation, and magnetic field. The modeled equations are relegated to the ordinary system of differential equations by substituting similarity variables. The ND-solve approach is applied for the modeled equations to numerically handle and generate a dataset. Several activities, including testing, verification, and training, are performed by creating a scheme for various fluid problems using reference data sets. The precision of LM-BP-ANNs is evaluated using mean square error, curve fitting error histogram, and the regression analysis plot. Furthermore, graphs are used to analyze flow parameters for concentration, momentum, and energy profiles. It has been observed that the velocity field declines as the magnetic field grows stronger. The THNF model for energy, mass, and momentum equations is tested, authenticated, and trained within an average of 10−9. The LM-BP-ANNs accomplish the highest accuracy, with a target date and absolute error reference values in the 10−4 to 10−5 range.