BACKGROUND High consequence infectious diseases (HCIDs) have potential to cause a high mortality rate among otherwise healthy populations. In partnership with the state department of health, a universal disease screening algorithm was developed to detect HCIDs and other infectious diseases. This screening tool was piloted in several locations, and staff provided feedback through pre- and post-pilot surveys. METHODS The new screening algorithm was piloted at three sites, an emergency department at a tertiary hospital, a specialty outpatient facility, and a family medicine clinic. Pre- and post-pilot surveys were completed by frontline staff to identify potential barriers, knowledge gaps, and comfort with the tool. Each site completed the novel screening alongside the current travel screening process at check-in for two weeks. Upon completion, surveys and screening results were compared to the existing process for time expenditure, staff perceptions, and sensitivity and specificity of the tools. RESULTS During the pilot, 1894 surveys were completed; of this number, 69 (3.64%) of the patients reported a fever, which prompted assessment for possible exposure and recent travel. Of the patients who reported a fever, 3/1894 (0.16%) had travel or exposure and were classified as “at risk” and 1/1894 (0.05%) had additional symptoms along with travel/exposure and were classified as “suspect” for an HCID. Per survey results, staff reported no significant time increase with the new process, but felt that additional education on HCIDs was needed. CONCLUSIONS The goals of this pilot were to develop a screening tool that efficiently detects HCIDs in healthcare settings and identify barriers to best practice. The results demonstrate a need for simple, effective screening tools, workflows, and staff education on infectious disease management. Using a universal screening model, facilities can improve their capability to prevent exposures, decrease response time, and reduce morbidity /mortality related to HCIDs.