Abdominal aortic aneurysms (AAA) are diagnosed in over 200,000 patients per year in the United States. Endovascular AAA repair offers a strategy for those unable to undergo open operation; however there still exists a treatment gap for those whose anatomy is not suitable for current stent graft options. In response to this need for novel therapeutics to prevent aneurysm proliferation, the objective of this work was to expand AAA treatment options via anti-inflammatory hydrogel application with a handheld bioprinting device. Induction of AAA in 8-week-old, male, Sprague-Dawley rats was achieved via intraluminal infusion of porcine elastase and topical application of calcium chloride to the infrarenal aorta. Following a 4-week incubation period, rats were treated with IL-10 loaded hydrogel or blank control hydrogel. The IL-10 loaded hydrogel was placed concentrically around the aorta from the lowest renal artery to the aortic bifurcation. Rats were sacrificed 4 weeks post-treatment. Histologic analysis included hematoxylin and eosin, picrosirius red, and Verhoeff-Van Gieson for inflammatory cell infiltration, collagen and elastin content, respectively. Three-dimensional aneurysm reconstruction and analysis was performed using SkyScan1076 micro-CT at baseline, post-induction/pre-treatment and sacrifice. Immunohistochemistry (IHC) was used to examine the presence of macrophage infiltration (ED1/CD68) as a marker of inflammation. Three-dimensional reconstruction demonstrated appropriate aneurysm formation in both groups and successful aneurysm mitigation in the treatment group only. Post-mortem histologic analysis showed irregularity of the aortic intima, fibrosis, abnormal collagen organization and dramatically decreased elastin concentration in control rodents while treated rats demonstrated preservation of aortic architecture. IHC demonstrated a significant increase in macrophage infiltration in the control group when compared to treated. Taken together, the results demonstrate that peri-aortic application of an IL-10 loaded hydrogel mitigates AAA expansion in a rat model. This novel approach may be a potential strategy for treating patients with AAA whose anatomy is unsuitable for endovascular intervention.