Higher education institutions have been aware of the mutually beneficial interaction between Higher Education 4.0 (HE4.0), Industry 4.0 (I4.0), and Work 4.0 (W4.0). Teaching and learning (T&L) are best accomplished through the novel and blended approaches in today's smart manufacturing, services, and labor processes. The traditional T&L methods no longer complement the fourth industrial revolution and the future of work skills. Little research has focused on innovative pedagogies in Higher Education Institutions (HEIs) globally and especially in South Africa from the Learning Ecosystem Framework perspective. This paper begins to address this void via a review of academic literature, aiming to understand new pedagogies of teaching and learning in HEIs and their effectiveness as we move into HE4.0. The emphasis of higher education research worldwide should be on reviewing and synthesizing current research outputs rather than performing new studies since there are fewer systematic literature reviews and a blend of systematic-narrative literature review approaches published in higher education journals. In light of this, exhaustive systematic-narrative literature reviews have been conducted to aggregate research findings within the context of global higher education pedagogy. Combined, this encompasses an analysis of 138 papers across different academic databases. We concluded that integrating teaching and learning methodologies such as flipped classroom, SCALE-UP, and blended teaching and learning are the most effective, sustainable, and student-centered pedagogy. Combining these teaching and learning approaches will ensure that students receive dynamic support, hands-on activities, practical assessments, active collaboration, and inquiry-based learning. Overall, our findings revealed that we need all parts of the learning ecosystem to work together toward teaching and learning that is transgressive, innovative, transformative, diverse, and inclusive with the I4.0, HE4.0, and W4.0 in mind – that is, if we aim to achieve effective blended teaching and learning, and sustainable student-centered academic output. Here, we point out where these discoveries might take us in research and what policies should be revised.