Abstract A sequence of magnetized target fusion (MTF) devices built by General Fusion have compressed magnetically confined deuterium plasmas inside imploding aluminum liners. Here we describe the best-performing compression experiment, PCS-16, which was the fifth of the most recent experiments that compressed a spherical tokamak plasma configuration. In PCS-16 the plasma remained axisymmetric with δBpol/Bpol < 20% to a high radial compression factor (CR > 8) with significant poloidal flux conservation (77% up to CR = 1.7, and ≈30% up to CR = 8.65) and a total compression time of 167 μs. Magnetic energy of the plasma increased from 0.96 kJ poloidal and 17 kJ toroidal to a peak of 1.14 kJ poloidal and 29.9 kJ toroidal during the compression, while thermal energy was in the range of 350 ± 25 J. Plasma equilibrium was a low-β state with βtor ≈ 4% and βpol ≈ 15%. Ingress of impurities from the lithium coated aluminum wall was not a dominant effect. Neutron yield from D-D fusion increased significantly during compression. Thermodynamics during the early phase of compression (CR < 1.7) were consistent with increasing Ohmic heating of the electrons due to a geometric rise in the current density at near-constant resistivity, and with increasing ion cooling that approximately matched ion compressional heating power. Ion cooling by electrons was significant because the electrons were cooler than the ions (Te = 200 eV, Ti = 600 eV). Magnetohydrodynamic simulation was used to model the emergence of instabilities that increased electron thermal transport in the final phase of compression. Conditions for ideal stability were actively maintained during compression through a current ramp applied to the central shaft, and after this current ramp reached its peak two-thirds of the way through compression we measured a transition in plasma behavior across multiple diagnostics.