The paper reflects the progressive attention given to Smart Specialization Strategies (S3) in boosting the implementation of Europe 2020 strategy at regional and local level. The aim is to focus on the potentials that the so-called Living Labs can reveal by connecting the urban regeneration with the S3, considering the current European programming period. The Living Lab, based on Open Innovation Model, is conceived as “smart interface” among enterprises, researchers, citizens and public authorities in order to respond the increasing service demand, to stimulate creativity for new ideas, markets with the use of KETs. Itcombines spatial dimension with innovation.
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