Current Production Systems Research Articles

Seeing the Animal: On the Ethical Implications of De-animalization in Intensive Animal Production Systems

This article discusses the notion that the invisibility of the animalness of the animal constitutes a fundamental obstacle to change within current production systems. It is discussed whether housing animals in environments that resemble natural habitats could lead to a re-animalization of the animals, a higher appreciation of their moral significance, and thereby higher standards of animal welfare. The basic claim is that experiencing the animals in their evolutionary and environmental context would make it harder to objectify animals as mere bioreactors and production systems. It is argued that the historic objectification of animals within intensive animal production can only be reversed if animals are given the chance to express themselves as they are and not as we see them through the tunnel visions of economy and quantifiable welfare assessment parameters.

Control and prevention of antibiotic residues and contaminants in sheep and goat’s milk

The use of veterinary drugs to treat mastitis and other pathologies in dairy sheep and goats is a usual practice in current production systems. The risk of antibiotic residues in milk on farms is high if good farming practices are not applied, in this sense control measures must be implemented to prevent drug residues from entering the food chain. Moreover there are other compounds that may contaminate milk via the environment, water or animal feed, such as mycotoxins that are one of the most harmful contaminants given their negative effects on consumer health. This work presents the problems that arise when residues and contaminants are present in sheep and goat’s milk. It also addresses the causes and the consequences of their presence, and the main measures of prevention and control required to guarantee milk that is safe for consumers and of high quality for the dairy industry.

Poultry production systems and its feed resources in Ethiopia: a research review

This study was done with the objective of assessing the current poultry production system, feed resources and provides valuable information for researchers, producers, instructors and policy makers in Ethiopia. The review was done deeply with original research findings of different scholars working on poultry. This study revealed that there are three poultry production systems classified based on the input, flock size, health and bio-security measures (village poultry production, small scale and commercial production systems). The main poultry feed resources in the country are household wastes, cereal grains and their by-products, industrial by products, oil seed cakes and non-conventional feed resources. There is shortage of commercial feed resources and processing meals thought it is expensive. In conclusion, the most common production system practiced in the major farming community is the village production system with irregular supplementation of cereal grains Therefore, investors and government institutions should avail the concentrate feeds with affordable price to improve the production and productivity of poultry in Ethiopia.

Interdisciplinary Development of Production Systems Using Systems Engineering

Currently Systems Engineering is used in product development to support interdisciplinary collaboration and to manage rising complexities at a given time and cost frame. Production system development is facing similar challenges. Especially production systems for mechatronic products and Cyber Physical Systems demand interdisciplinary approaches. Therefore this paper investigates how Systems Engineering can be applied to cope with these arising challenges in production system development. On the basis of a comparison between current production system development procedures and Systems Engineering methodologies, potential improvements are identified and a tailored production system development approach is presented.

Discrete Event Simulation Modelling for Dynamic Decision Making in Biopharmaceutical Manufacturing

With the increase in demand for biopharmaceutical products, industries have realised the need to scale up their manufacturing from laboratory-based processes to financially viable production processes. In this context, biopharmaceutical manufacturers are increasingly using simulation-based approaches to gain transparency of their current production system and to assist with designing improved systems. This paper discusses the application of Discrete Event Simulation (DES) and its ability to model the various scenarios for dynamic decision making in biopharmaceutical manufacturing sector. This paper further illustrates a methodology used to develop a simulation model for a biopharmaceutical company, which is considering several capital investments to improve its manufacturing processes. A simulation model for a subset of manufacturing activities was developed that facilitated ‘what-if’ scenario planning for a proposed process alternative. The simulation model of the proposed manufacturing process has shown significant improvement over the current process in terms of throughout time reduction, better resource utilisation, operating cost reduction, reduced bottlenecks etc. This visibility of the existing and proposed production system assisted the company in identifying the potential capital and efficiency gains from the investments therefore demonstrating that DES can be an effective tool for making more informed decisions. Furthermore, the paper also discusses the utilisation of DES models to develop a number of bespoke productivity improvement tools for the company.

Hybrid Process of Laser Heat Treatment and Forming of Thin Plate with a Small Power Semiconductor Laser

In recent years, the recycling of resources has become important because of the aggravation of global environmental concerns. In light of this, it is necessary to minimize the resource needs of current production systems. This concept is called sustainable development. When this concept is applied to machine tools, the assumption is that small parts should be processed using small machines. Additionally, the diversification of consumer needs and the ephemeralization of product life cycles are progressing in industry. As a result, the overall production system has changed from high-mix low-volume production manufacturing, to variant types in variable quantity. In this background, the cell production system is receiving attention as a production system that can achieve variant types in variable quantity. The cell production system also requires miniaturization and process consolidation of machine tools, which has given rise to the need to consolidate heat treatments, especially as part of the process consolidation of machine tools. Laser beams have proved to be effective heat sources when integrated into heat-treatment processes, such as quenching and tempering on machine tool tables. On the other hand, In the case of the thin plate, it is well known that the deformation of a plate occurs due to laser irradiation, as named a laser forming. The laser forming is also effective to generate the complex shape without a press die set. Thus, we propose that the hybrid process of laser heat treatment and forming of thin plate with a small power semiconductor laser, and demonstrate that the proposed method makes it feasible to generate the hardened sheet metal products with a compact machine tools. Moreover, considering the power consumption in laser quenching and forming process, we investigate an appropriate laser irradiation condition from a view of reducing the environmental burden.

Distributable Modular Software Framework for Manufacturing Systems

Modern production processes have a high demand on reliability, automation and accuracy in order to avoid defects during the manufacturing process. Each production differs in its demands, with which can be dealt by using intelligent decision making software. In current production systems for each evaluation of a vital process parameter a different software system is used.A modular software framework was developed which can be easily adapted to different production processes and different sensor inputs. It also supports an easy nearly “plug&play” integration of new processing algorithms. Thus making it possible to deal with multiple evaluation within one process and throughout different machines and processes using one common software framework architecture.The software consists of different basic modules connected via the framework and a common data structure. The modules can be customized using a simple configuration file.The framework connects the main modules data acquisition, data preparation, processing algorithms, decision making, a database and the controller integration. All of the modules are optional and can be adjusted with the configuration file.By using a common data structure and communication protocol it is also possible to distribute the modules over different PCs and machines as long as they are connected by a network.This features are creating a software framework able to be adapted easily to different use cases within one production process and also different production processes.This software was successfully integrated into production environments within a European project realizing an in-process real time control of the machine to minimize defects.

Evaluation of tomato production systems at Bowen in mitigating the risk of fruit fly infestation: a systems approach for market access

Queensland fruit flies Bactrocera tryoni and B. neohumeralis are considered major quarantine pests of tomato, a major crop in the horticultural production district around Bowen, North Queensland, Australia. Preharvest and/or postharvest treatments are required to meet the market access requirements of both domestic and international trading partners. The suspension from use of dimethoate and fenthion, the two insecticides used for fruit fly control, has resulted in the loss of both pre and postharvest uses in fresh tomato. Research undertaken quantitatively at Bowen evaluated the effectiveness of pre-harvest production systems without specific fruit fly controls and postharvest mitigation measures in reducing the risk of fruit fly infestation in tomato. A district-wide trapping using cue-lure baited traps was undertaken to determine fruit fly seasonal patterns in relation to the cropping seasons. A total of 17,626 field-harvested and 11,755 pack-house tomatoes were sampled from ten farms over three cropping seasons (2006-2009). The fruit were incubated and examined for fruit fly infestation. No fruit fly infested fruit were recorded over the three seasons in either the field or the pack-house samples. Statistical analyses showed that upper infestation levels were extremely low (between 0.025 and 0.062%) at the 95% confidence level. The trap catches showed a seasonal pattern in fruit fly activity, with low numbers during the autumn and winter months, rising slightly in spring and peaking in summer. This seasonal pattern was similar over the four seasons. The main two species of fruit fly caught were B. tryoni and B. neohumeralis. Based on the results, it is clear that the risk of fruit fly infestation is extremely low under the current production systems in the Bowen region.

SPATIAL QUALITY ASSESSMENT OF PESTICIDE APPLICATIONS USING A CANNON SPRAYER - DOI: 10.13083/1414-3984/reveng.v23n5p418-427

One of the critical points of the current system of crop production is the use of pesticides, which in addition to increasing the cost of production, can cause direct and indirect environmental contamination. This study aimed at evaluating the spatial variability of the quality of the pesticide applications using a cannon sprayer. Hydrosensitive paper targets were placed on the soil every two meters in the direction of the air flow until the maximum range of 30 m, and also in the direction of the tractor movement, placed every 6 m until the maximum distance of 30 m, forming a 90 m² area. Operational parameters of the Volume Median Diameter (VMD), Coefficient of homogeneity (CH), Target coverage (%C) and Density of droplets (DD) were evaluated. The data were submitted to a descriptive analysis and a subsequent geostatistical analysis in order to construct maps for the variables. The sprayer was not considered capable of performing efficient pesticide applications while maintaining good application uniformity, even in proper operating conditions.

Investigating Impacts of Alternative Crop Market Scenarios on Land Use Change with an Agent-Based Model

We developed an agent-based model (ABM) to simulate farmers’ decisions on crop type and fertilizer application in response to commodity and biofuel crop prices. Farm profit maximization constrained by farmers’ profit expectations for land committed to biofuel crop production was used as the decision rule. Empirical parameters characterizing farmers’ profit expectations were derived from an agricultural landowners and operators survey and integrated in the ABM. The integration of crop production cost models and the survey information in the ABM is critical to producing simulations that can provide realistic insights into agricultural land use planning and policy making. Model simulations were run with historical market prices and alternative market scenarios for corn price, soybean to corn price ratio, switchgrass price, and switchgrass to corn stover ratio. The results of the comparison between simulated cropland percentage and crop rotations with satellite-based land cover data suggest that farmers may be underestimating the effects that continuous corn production has on yields. The simulation results for alternative market scenarios based on a survey of agricultural land owners and operators in the Clear Creek Watershed in eastern Iowa show that farmers see cellulosic biofuel feedstock production in the form of perennial grasses or corn stover as a more risky enterprise than their current crop production systems, likely because of market and production risks and lock in effects. As a result farmers do not follow a simple farm-profit maximization rule.

Air pollutant emissions inventory of large‐scale production of selected biofuels feedstocks in 2022

AbstractFor climate protection and energy security reasons, biofuels are proposed to replace a significant fraction of fossil transportation fuel. Recognition of differences in production pathways between biofuels and fossil fuels has motivated an emerging literature that considers air quality and human health impacts of potential changes to the magnitude, location, timing, and type of air pollutants emitted. To inform research and development of advanced biofuel production systems as well as air quality management decisions, we have developed a highly resolved inventory of air pollutant emissions for a baseline scenario of current and future US biofuel feedstock production systems using data from recent research. We find that in most US counties, production of cellulosic biofuel feedstocks using advanced practices exhibits lower air pollutant emissions than current corn grain production. An analysis of the contributing sources to each of the seven evaluated air pollutants helps identify emission reduction opportunities. Compared to the 2008 National Emissions Inventory, production of cellulosic biofuel feedstocks to meet regulatory requirements in 2022 typically represents small increments of air emissions, though for certain pollutants and counties, a threshold may be reached whereby further examination may be warranted to ensure air quality standards can be achieved. Given that the advanced biofuel supply chain system is in its infancy, considerable opportunities exist to minimize adverse impacts while maximizing the benefits of advanced biofuels. This analysis enables more informed technology development decisions and identification of mitigation opportunities in the biofuel feedstock production stage. © 2015 Society of Chemical Industry and John Wiley & Sons, Ltd

Hybrid Process of Laser Heat Treatment and Forming of Thin Plate with a Small Power Semiconductor Laser

In recent years, the recycling of resources has become important because of the aggravation of global environmental concerns. In light of this, it is necessary to minimize the resource needs of current production systems. This concept is called sustainable development. When this concept is applied to machine tools, the assumption is that small parts should be processed using small machines. Additionally, the diversification of consumer needs and the ephemeralization of product life cycles are progressing in industry. As a result, the overall production system has changed from high-mix low-volume production manufacturing, to variant types in variable quantity. In this background, the cell production system is receiving attention as a production system that can achieve variant types in variable quantity. The cell production system also requires miniaturization and process consolidation of machine tools, which has given rise to the need to consolidate heat treatments, especially as part of the process consolidation of machine tools. Laser beams have proved to be effective heat sources when integrated into heat-treatment processes, such as quenching and tempering on machine tool tables. On the other hand, In the case of the thin plate, it is well known that the deformation of a plate occurs due to laser irradiation, as named a laser forming. The laser forming is also effective to generate the complex shape without a press die set. Thus, we propose that the hybrid process of laser heat treatment and forming of thin plate with a small power semiconductor laser, and demonstrate that the proposed method makes it feasible to generate the hardened sheet metal products with a compact machine tools. Moreover, considering the power consumption in laser quenching and forming process, we investigate an appropriate laser irradiation condition from a view of reducing the environmental burden.

Economic feasibility of animal welfare improvements in Dutch intensive livestock production: A comparison between broiler, laying hen, and fattening pig sectors

This study compared the economic feasibility of production systems with different levels of animal welfare (AW) in the broiler, laying hen, and fattening pig sectors. Economic feasibility over a five-year time horizon was assessed using stochastic bio-economic simulation models. The results suggest that the main determinant of economic feasibility in each sector is the producer price. It is not only the level of the price premium but also the certainty and variability of this premium that is important in the decision to convert to an alternative system. From the perspective of the farm, different approaches should be followed in the three sectors to further develop the market for products with higher levels of AW. The results imply that the broiler sector has the best perspective in the short to medium term for developing this market. In the fattening pig sector, conversion options should be made more financially attractive, for example by increasing price premiums or providing conversion subsidies. The laying hen sector has the worst prospects for improving AW in the short to medium term. Therefore, given the current production systems in this sector, producer price premiums need to be increased in order to increase the adoption of alternative production systems.

Genomics enabled breeding approaches for improving cadmium stress tolerance in plants

Heavy metal (HM) toxicity is a considerable challenge that the current agricultural production systems and human population face worldwide. Among the HMs with pronounced toxic effects, cadmium (Cd) potentially contaminates a range of vital agricultural resources including soil and water together with severely impacting crop performance. Besides, gradual accumulation of Cd in food chain poses a global threat to food safety and environmental sustainability. Plants are equipped with meticulously orchestrated physiological and molecular mechanisms to respond and acclimatize to Cd-challenged scenarios. However, limited understanding about the HM toxicity mechanism involving metal uptake/transport, associated candidate gene (s) or QTLs and signaling crosstalk has greatly constrained breeding capacities to improve plants for HM tolerance. In the context, quantifying genetic variation for Cd tolerance accompanied by appropriate breeding schemes allowing the most efficient utilization of the estimated variation should be essentially undertaken. Concurrently, efforts are needed to facilitate fast-track introgression of genomic segments harboring candidate gene(s)/QTL for Cd tolerance to high yielding yet Cd-susceptible backgrounds. Advances in plant molecular biology have introduced refined techniques and methods to pinpoint genetic factors describing plant Cd tolerance. Ancillary to conventional breeding and marker assisted selection methods are modern transgenic technologies that offer attractive means to precisely interrogate the relevant molecular networks and manipulate the key Cd-related genes in plants.

Optimum Planting Configuration for High Population Plasticulture Grown Cabbage

Florida is a major fresh-market cabbage (Brassica oleracea L. var. capitata) producing state in the United States. The current cabbage production system relies on bare ground and subirrigation that requires a large volume of water to irrigate the crop. The bare ground system facilitates a maximum of 48,438 plant/ha, while there is a potential to increase plant population per area using plasticulture and drip irrigation. The objectives of this study were to determine the optimum cabbage plant population and plant arrangement that maximizes marketable yield per area for a high cabbage population plasticulture system. Cabbage was grown on 1.2-m-wide raised beds with black plastic mulch and drip irrigation. Plants were grown in either three or four rows with in-row plant spacings ranging from 15 to 35 cm and plant populations ranging from 41,518 to 129,167 plants/ha. Cabbage marketable yield increased as in-row spacing increased. Yields ranged from 19.7 to 69.7 Mg·ha−1. Marketable yield was not different between 3 and 4 rows for in-row spacings above 25 cm. The 15 and 20 cm in-row spacing produced significantly lower yields in the 4-row configuration as compared with the 3-row configuration in Fall and Winter 2011. Wider in-row spacings produced a greater percentage of heads of marketable size while reducing the percentage of small heads when compared with narrower in-row spacings. Mean head weight increased as in-row spacing increased and a 3- or 4-row configuration with an in-row spacing between 25 and 30 cm had consistently high yields in all three seasons compared with narrower in-row plant spacings. These results indicated that with a high population plasticulture system variable plant populations could be selected. In-row plant spacings between 30 and 35 cm may be beneficial for early plantings while a 25-cm spacing could be more productive for later plantings, especially when weather conditions are favorable.

Activation of human mast cells by retrocyclin and protegrin highlight their immunomodulatory and antimicrobial properties.

Preclinical evaluation of Retrocyclins (RC-100, RC-101) and Protegrin-1 (PG-1) antimicrobial peptides (AMPs) is important because of their therapeutic potential against bacterial, fungal and viral infections. Human mast cells (HMCs) play important roles in host defense and wound healing but the abilities of retrocyclins and protegrin-1 to harness these functions have not been investigated. Here, we report that chemically synthesized RC-100 and PG-1 caused calcium mobilization and degranulation in HMCs but these responses were not blocked by an inhibitor of formyl peptide receptor-like 1 (FPRL1), a known receptor for AMPs. However, RC-100 and PG-1 induced degranulation in rat basophilic leukemia (RBL-2H3) cells stably expressing Mas related G protein coupled receptor X2 (MrgX2). Chemical synthesis of these AMPs is prohibitively expensive and post-synthesis modifications (cyclization, disulfide bonds, folding) are inadequate for optimal antimicrobial activity. Indeed, we found that synthetic RC-100, which caused mast cell degranulation via MrgX2, did not display any antimicrobial activity. Green-fluorescent protein (GFP)-tagged RC-101 (analog of RC-100) and GFP-tagged PG-1 purified from transgenic plant chloroplasts killed bacteria and induced mast cell degranulation. Furthermore, GFP-PG1 bound specifically to RBL-2H3 cells expressing MrgX2. These findings suggest that retrocyclins and protegrins activate HMCs independently of FPRL1 but via MrgX2. Harnessing this novel feature of AMPs to activate mast cell's host defense/wound healing properties in addition to their antimicrobial activities expands their clinical potential. Low cost production of AMPs in plants should facilitate their advancement to the clinic overcoming major hurdles in current production systems.

Is cross-breeding of cattle beneficial for the environment? The case of mixed farming systems in Central Java, Indonesia

SummaryCross-breeding with European beef breeds has become a standard approach for the intensification of smallholder cattle production in Indonesia. This study assessed the environmental impact of cross-breeding, in terms of Global Warming Potential (GWP) and land use. We sampled 90 local Ongole and 162 cross-bred (Simmental × Ongole) cattle farms in four study areas. Expressed per kilogram of live weight of young stock produced, GWP (26.9 kg CO2–equivalents) and land use (34.2 m2) of farms with Ongole breeding stock were not significantly different from the GWP (28.9 kg CO2–equivalents) and land use (37.4 m2) of cross-bred farms. Cross-bred young stock grew faster, but in general cross-bred cattle required more feed. In the current smallholder production system, the dominant cross-breeding practice of using Simmental semen on Ongole andF1cross-bred cows does not result in lower greenhouse gas emissions or land use per kilogram of live weight produced compared with farms with Ongole cows. The advantage from the faster growth of cross-breds is counteracted by the higher emissions from feed production for cross-breds.

Low-cost oral delivery of protein drugs bioencapsulated in plant cells.

Biopharmaceuticals made using current production systems are prohibitively expensive and are not affordable for a large majority of the global population. The cost of protein drugs ($140 billion in 2013) exceeds GDP of >75% of countries around the globe (Walsh, 2014), making them unaffordable in these countries. The one-third of the global population that earns <$2 per day cannot afford any protein drugs. This is because of their production in prohibitively expensive fermenters, purification, cold storage/transportation, short shelf life and sterile delivery methods. Simpler methods of delivery such as oral dosing could obviate much of the expense: however, oral delivery of protein drugs has been elusive for decades because of their degradation in the digestive system, inability to cross the gut epithelium and delivery to target cells/tissues.

In vitro glycoengineering of IgG1 and its effect on Fc receptor binding and ADCC activity.

The importance and effect of Fc glycosylation of monoclonal antibodies with regard to biological activity is widely discussed and has been investigated in numerous studies. Fc glycosylation of monoclonal antibodies from current production systems is subject to batch-to-batch variability. If there are glycosylation changes between different batches, these changes are observed not only for one but multiple glycan species. Therefore, studying the effect of distinct Fc glycan species such as galactosylated and sialylated structures is challenging due to the lack of well-defined differences in glycan patterns of samples used. In this study, the influence of IgG1 Fc galactosylation and sialylation on its effector functions has been investigated using five different samples which were produced from one single drug substance batch by in vitro glycoengineering. This sample set comprises preparations with minimal and maximal galactosylation and different levels of sialylation of fully galactosylated Fc glycans. Among others, Roche developed the glycosyltransferase enzyme sialyltransferase which was used for the in vitro glycoengineering activities at medium scale. A variety of analytical assays, including Surface Plasmon Resonance and recently developed FcγR affinity chromatography, as well as an optimized cell-based ADCC assay were applied to investigate the effect of Fc galactosylation and sialylation on the in vitro FcγRI, IIa, and IIIa receptor binding and ADCC activity of IgG1. The results of our studies do not show an impact, neither positive nor negative, of sialic acid- containing Fc glycans of IgG1 on ADCC activity, FcγRI, and RIIIa receptors, but a slightly improved binding to FcγRIIa. Furthermore, we demonstrate a galactosylation-induced positive impact on the binding activity of the IgG1 to FcγRIIa and FcγRIIIa receptors and ADCC activity.

OneBac 2.0: Sf9 Cell Lines for Production of AAV5 Vectors with Enhanced Infectivity and Minimal Encapsidation of Foreign DNA.

Scalable production of recombinant adeno-associated virus vectors (rAAV) in baculovirus-infected Sf9 cells yields high burst sizes but variable infectivity rates per packaged AAV vector genome depending on the chosen serotype. Infectivity rates are particularly low for rAAV5 vectors, based on the genetically most divergent AAV serotype. In this study we describe key improvements of the OneBac system for the generation of rAAV5 vectors, whose manufacturing has been unsatisfactory in all current insect cell-based production systems. The Sf9 cell-based expression strategy for AAV5 capsid proteins was modified to enhance relative AAV5 VP1 levels. This resulted in a 100-fold boost of infectivity per genomic AAV5 particle with undiminished burst sizes per producer cell. Furthermore, the issue of collateral packaging of helper DNA into AAV capsids was approached. By modifications of the AAV rep and cap expression constructs used for the generation of stable Sf9 cell lines, collateral packaging of helper DNA sequences during rAAV vector production was dramatically reduced down to 0.001% of packaged rAAV genomes, while AAV5 burst sizes and infectivity rates were maintained. OneBac 2.0 represents the first insect cell-based scalable production system for high per-particle AAV5 infectivity rates combined with minimal collateral packaging of helper DNA, allowing the manufacturing of safe AAV5-based gene therapies for clinical application.