Current solar and atmospheric neutrino oscillation data seem to favor a bimaximal pattern for neutrino mixings where the matrix elements U_{e2} and U_{\mu 3} are of order one, while U_{e3} is much smaller. We show that such a pattern can be obtained quite easily in theories with ``lopsided'' mass matrices for the charged leptons and the down type quarks. A relation connecting the solar and atmospheric neutrino mixing angles is derived, \tan^2\theta_{atm} \simeq 1+ \tan^2\theta_{sol}, which predicts \sin^2 2\theta_{atm} \simeq 0.97 corresponding to the best fit LMA solution for solar neutrinos. Predictive schemes in SO(10) realizing these ideas are presented. A new class of SO(10) models with lopsided mass matrices is found which makes use of an adjoint VEV along the I_{3R} direction, rather than the traditional B-L direction.
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