Widespread and long-term shifts in weather patterns are contributing to further degradation of surface water quality. This challenge caused by the increasing frequency of extreme weather events requires appropriate adaptation of current mitigation strategies. But to confirm the need to redesign such strategies, an understanding of the impacts of increasing weather extremes on pollutant losses in different catchment types is required. With this in view, this study investigated the impact of changing weather patterns on the inter-seasonal and inter-annual dynamics of nutrient losses in six agricultural catchments in Ireland over 11 years. The high temporal resolution data (10-min) from these intensively managed catchments represented different characteristics and management practices. Mann-Kendall Trend Analysis and Generalised Additive Models were used to study nutrient concentration trends, and to investigate the significance of water discharge, precipitation, potential evapotranspiration, soil moisture deficit, air temperature, and soil temperature on the losses of nutrients, respectively. The analysis of historical data revealed changes in the trends of daily average nitrate (NO3-N), phosphorus (P), and suspended sediment (SS) concentrations in association with significant increasing trends in air temperature, soil temperature, and precipitation across the same month over 11 years of monitoring. While discharge was significantly contributing to the concentrations of NO3-N, P, and SS across different catchments, air and soil temperature were significantly correlated to NO3-N losses, and precipitation was the major contributor to regulating P (total P and total reactive P) concentrations. In short, air temperature, soil temperature, soil moisture deficit, and precipitation were the main climatic drivers regulating the nutrient concentrations while the soil chemistry and drainage status were the non-climatically related drivers. The results revealed that the extent of the impact of climatic drivers depends on catchment characteristics. Therefore, expanding the application of this type of study would facilitate better understanding of current and future challenges to water management and provision of climate-resilient mitigation strategies for different catchment typologies.