Abstract This study used the denitrification–decomposition (DNDC) model and ArcGIS 10.1 to calculate and quantify the greenhouse gas (GHG) potential from rice and annual upland crops in the Red River Delta of Vietnam. GHG emissions were monitored, analyzed, and calculated at experimental sites. The operating mechanism, sensitivity analysis of the parameters, calibration, and verification of the DNDC model for the GHG emission calculation were studied and performed, and a set of parameters was built. A good correlation between actual and simulated values was shown. From the data set of meteorological stations in and around the Red River Delta, the current land-use map, the topographic and soil map, a complex map of meteorology–soil–land use was built. Each unit of this map contains complete information about climate, soil, and crops as input data for modeling GHG emissions from crop production. From the spatial analysis and collected input data, GHG emissions were measured and calculated for the cultivated field of the Red River Delta (annual rice and upland crops) using the DNDC model. The model's outputs were used to build thematic maps on the distribution of global warming potential (CH4, N2O) for each unit of the complex map of climate, soil, and crops.