Current Era Research Articles

Pengaruh Kompetensi dan Kerja Sama Tim Terhadap Kinerja Pegawai Desa Karyamukti Kecamatan Lemahabang

In the current era of globalization, human resource management has a very crucial role in increasing the efficiency of resource use within the organization to achieve common goals. In this case, the influence provided by competence and teamwork supports the optimization and improvement of employee performance. Therefore, this research aims to find out, analyze and explain the influence of Competency and Teamwork on Employee Performance. The research method used is verification analysis with a quantitative approach. The sampling method used in this research was using a non-probability sampling method with a saturated sampling technique because the sample size was less than 100 people, so all members of the population were sampled. Research data was obtained by distributing questionnaires via Google Form to 45 respondents from Karyamukti Village employees, Lemahabang District. Then, the data analysis method used is path analysis (Path Analysis) with the help of SPSS 23 software. The results of the discussion in this research show that there is a correlation between the Competency and Teamwork variables. There is a partially significant positive influence of each variable between Competence and Teamwork on Employee Performance. And there is also a significant positive influence simultaneously on the Competency and Teamwork variables on Employee Performance.

Tren Fashion Syariah dalam Digitalisasi Marketing di Era Milineal dan Gen Z

In the current era of digitalization of marketing, fashion is developing very rapidly, including Muslim or sharia fashion, so with this development, the author wants to know what fashion trends among millennial and generation Z children are in accordance with sharia rules and wants to know the understanding of millennial and gen Z children regarding ethical behavior. get dressed. The method used is a literature review using a descriptive qualitative approach, by reviewing several literature articles, then concluding the results of the problem, namely that the millennial generation and Gen Z with digital marketing are increasingly fashionable due to the ease of accessing various fashion models and in fashion they only consider it as covering the body (aurat), increasing self-confidence and self-identity as a Muslim, but does not pay attention to or understand the rules and ethics in applying fashion trends.

Problematika Kesehatan Mental di Era Disrupsi dan Solusinya dalam Al-Qur’an- Hadis

Fundamental changes take the form of technological evolution that looks for loopholes to influence human life. The current era of revolutionary transformation has triggered widespread mental health disorders in Indonesia which continue to increase. It is noted that the majority of suicide cases in Indonesia are young people and the biggest factor is mental health. Because mental health greatly influences a person's quality of life. Currently we have entered the disruption phenomenon, which is a major part of the global scale. Where in the era of disruption there is a mental health crisis. It can be seen that cases of young people are increasing. The aim of this research is to find out mental health in the era of disruption and the solutions in the Al-Qur-an and Hadith. The method used in this research is library research, namely a series of activities relating to library data collection methods. This research uses a qualitative approach and then describes it descriptively. For the results, the solution is to build one's foundation with the Al-Qur'an, multiply good works and avoid evil (amar ma'ruf nahi munkar). Build a good relationship with Allah by remembering Him more (dhikr). Then develop relationships with others and their environment. The source of a human's strength lies in his self-esteem. Self-esteem is the most important axis in strengthening mental health.

Bone aluminum accumulation in the current era

Nos últimos anos, evidências do Registro Brasileiro de Biópsia óssea (REBRABO) apontaram uma alta incidência de intoxicação por alumínio (Al) no tecido ósseo de pacientes com DRC em diálise. Essa surpreendente informação parece representar não apenas um acúmulo passivo deste metal, visto que dados prospectivos do REBRABO sugerem que a presença de Al no tecido ósseo pode estar independentemente relacionada a eventos cardiovasculares adversos maiores. Essas informações contrastam com a percepção mundial do controle epidemiológico dessa condição. Neste artigo de opinião, discutimos por que o diagnóstico de acúmulo ósseo de Al não é relatado em outras partes do mundo, e também discutimos uma gama de possibilidades para entender por que nós acreditamos que o acúmulo de Al no tecido ósseo ainda ocorre, não como se apresentava no passado, ou seja, como uma síndrome com sinais e sintomas sistêmicos de intoxicação.

DualFaceNet: augmentation consistency for optimal facial landmark detection and face mask classification

<p>In an era where face masks are commonplace, facial recognition faces new challenges and opportunities. This study introduces DualFaceNet (DFN), a cutting-edge neural network that efficiently combines facial landmark detection with mask classification. Benefiting from multi-task learning (MTL) and enhanced with a unique consistency loss, DFN outperforms traditional single-task models. Tests using the reputable 300W dataset and a face mask dataset showcase DFN’s strengths: a significant reduction in landmark error to 5.42 and an increase in mask classification accuracy to 92.59%. These results highlight the potential of integrating MTL and custom loss functions in facial recognition. As face masks continue to be globally essential, DFN’s integrated approach offers a fresh perspective in facial recognition studies. Furthermore, DFN paves the way for adaptive facial recognition systems, emphasizing the adaptability needed in our current era.</p>

Bone aluminum accumulation in the current era.

In the last few years, evidence from the Brazilian Registry of Bone Biopsy (REBRABO) has pointed out a high incidence of aluminum (Al) accumulation in the bones of patients with CKD under dialysis. This surprising finding does not appear to be merely a passive metal accumulation, as prospective data from REBRABO suggest that the presence of Al in bone may be independently associated with major adverse cardiovascular events. This information contrasts with the perception of epidemiologic control of this condition around the world. In this opinion paper, we discussed why the diagnosis of Al accumulation in bone is not reported in other parts of the world. We also discuss a range of possibilities to understand why bone Al accumulation still occurs, not as a classical syndrome with systemic signs of intoxication, as occurred it has in the past.

354. NEOADJUVANT CHEMORADIOTHERAPY FOLLOWED BY SURGERY VERSUS UPFRONT SURGERY FOR ESOPHAGEAL CANCER: LONG-TERM OUTCOMES IN A CROSS TRIAL STUDY CENTER

Abstract Background Since the publication of the CROSS-trial, showing improved survival following neoadjuvant chemoradiotherapy + surgery (CRT-S) compared to upfront surgery (U-S) for esophageal cancer, this neoadjuvant regimen has become standard care in the Netherlands. Given the relatively low R0 rate in the U-S arm (69%) and lymph node yield (LNY) in both arms (15 U-S, 18 CRT-S) observed in the CROSS-trial, the present study aimed to compare survival of patients who underwent CRT-S versus U-S in a tertiary referral center that participated in the CROSS-trial, within the era that the trial was performed. Methods This retrospective study included patients, who underwent an esophagectomy between 2004-2010, and met the CROSS-trial inclusion criteria. Primary outcome was 10-year overall survival (OS), and patients with CRT-S and U-S were compared. Secondary outcomes were R0-resection rate, LNY and positive LNY. Subgroup analyses were performed for histology (adenocarcinoma [AC] and squamous cell carcinoma [SCC] and for surgical approach (transthoracic [TTE] and transhiatal [THE] esophagectomy). Results We included 288 patients: 144 after CRT-S, 144 after U-S. 112 (39%) participated in the CROSS-trial. 10-year OS was not significantly better for CRT-S (40%) versus U-S (34%; p=0.183). In SSC, OS following CRT-S was 49% and after U-S 35% (p=0.228), versus 38% and 34% in AC (p=0.396). Following TTE, OS was better compared to THE in both CRT-S and U-S groups: 44% and 39% (p=0.369) versus 32% and 29% (p=0.590). R0-rates were 96% (CRT-S) and 86% (U-S). Median LNY was equal: 23. 55 (38%) and 100 (69%) patients had positive lymph nodes after respectively CRT-S and U-S. Conclusion This study showed that, with a radical TTE, comparable OS results can be achieved, and therefore CRT may not be indicated in all patients. Further analyses are necessary to identify patients who may benefit from the additional local treatment that CRT is (e.g SCC or involved circumferential resection margin). Additionally, surgical techniques have improved since the CROSS-trial, with less surgical trauma in minimally invasive esophagectomy. This may result in better outcomes for surgery nowadays, indicating the need for further studies in the current era.

Study of political developments in democratic, communist and dictatorial systems and their impact on power, governance and human rights

In the current era, the world is experiencing profound political and economic shifts, marking a departure from the norms that dominated the pre-industrial period. Notably, the dissolution of feudal and communal systems, which were emblematic of an economy rooted in pastoral ideologies, has been underway since the French Revolution. This transformative period has not only reshaped global dynamics but also led to the reconstitution of modern state structures within the context of institutional states. This research delves into the evolving patterns of political changes and their economic repercussions in the contemporary global landscape. Our study aims to decipher the dynamics of international transformations within the global political arena and explore their interconnections with the emerging world order. Furthermore, we have endeavored to trace the philosophical political roots that underpinned these economic systems, examining their genesis and subsequent influence on political developments across various regimes, with a particular focus on implications for human rights. An analytical methodology underpins our examination of these political transformations. Central to our inquiry is the following pivotal question: What is the impact of developments in political and economic systems in the contemporary world on authority, governance, and human rights? To address this question, we deemed it necessary to discuss three topics related to political transformation, presenting an analysis for each of the following axes: 1-Circumstances and history of modern political transformations. 2-Modern political demands, compared to advanced political aspirations. 3-Human rights, between liberal propaganda and democracy. Our findings reveal that political variables have undergone substantial changes that significantly influence political ideologies, the conceptualization of authority, and human rights considerations. Among these influential factors are: Globalization and Technology: Technological advancements and the expansion of global communications via the Internet have opened new avenues for political discourse and interaction. This development transcends local boundaries, positioning politics as a globally interconnected phenomenon. Social and Cultural Transformations: There has been a significant shift in social and cultural paradigms, particularly in the heightened awareness of human rights. This shift has broadened the scope of political thought and necessitated the integration of these issues into both national and international political dialogues. Economic Transformations: The evolution of economic structures, spurred by technological progress and globalization, has profound implications for political theories concerning the equitable distribution of wealth, economic opportunities, poverty alleviation, and addressing economic disparities.

The Impact of Smart Materials Usage in Buildings Envelope: an Approach to Investigate Energy Consumption Versus The Aesthetics Forming The City Image in New Agglomerations

Abstract The notion of creating New Agglomerations often demonstrates the challenge between maintaining city’s identity and the necessity to adopt contemporary building materials. The main target in the current era is to monitor the degree of sustainable strategies adopted while defining the potential materials used whether in the construction process or for final building envelopes. This study aims to evaluate the implications of energy-saving potential of smart glazing materials in building envelopes through a comparative analysis creating the emergent city image created by building façade systems. A thorough review presents various types of smart glazing materials performance versus traditional glazing systems, in terms of heating and cooling results. The research presents a case study of actual buildings deploying smart glazing systems to provide real-world evidence of their energy-saving potential. The results showed that smart glazing materials can significantly reduce energy consumption compared to traditional glazing systems. The results also indicated that the performance of smart glazing materials varies with different types of materials, and the specific energy-saving potential depends on factors such as building orientation, glazing area, and climate conditions. This study provides insights related to emergent design decisions for new agglomerations in terms of energy-efficient building envelopes and energy consumption strategies.

Penerapan Media Powtoon dalam Pembelajaran Teks Negosiasi Peserta Didik Kelas X-4 SMA N 5 Semarang

Learning media is a component that supports effectiveness in the learning process in Indonesian language subjects. In applying media in learning, teachers are advised to apply media that can make students interested in learning and raise their motivation in learning. As technology develops in the current digital era, there are more and more technology-based learning media. Powtoon media is a technology-based learning media that can attract students to learn and raise their motivation. This is because the media is an animated video that combines audio and visuals which can provide a special attraction in learning negotiation texts for class X-4 students. This research examines the application of Powtoon media in learning negotiation texts for class X-4 students at SMA N 5 Semarang. The main problem is the low interest of students in learning about negotiation text material which is delivered only through the lecture method without interactive learning media. Therefore, researchers apply new innovations in the learning process in the form of applying Powtoon media in learning negotiation texts with the aim of increasing activity so that students are more enthusiastic and active in learning, in addition to making students understand more about the structure of negotiation texts Powtoon media. The research method used is descriptive qualitative with data collection through tests and non-tests. The research results show that the application of Powtoon is effective in increasing student participation, this is shown by the test results of students with the highest score of 95 and the lowest score of 85, and non-test results in the form of interviews and observations show that students are active and enthusiastic in learning.

The impact of blood type and body size on successful bridging to heart transplantation using intra-aortic balloon pump or surgically implanted microaxial left ventricular assist device

ObjectiveWaitlist time for United Network for Organ Sharing Status 2 heart transplant candidates has steadily increased. We compared a bridging strategy using either the Impella 5.0/5.5 (“Impella”) or intra-aortic balloon pump with a durable left ventricular assist device in patients with blood type O stratified by body habitus. MethodsThe United Network for Organ Sharing registry was queried for adults listed for de novo heart transplantation (without dialysis) supported by the Impella, an intra-aortic balloon pump, or the HeartMate 3 left ventricular assist device. The primary outcome was 1-year postlisting survival, defined as the sum of waitlist time and post–heart transplant survival time if the candidate underwent heart transplantation. ResultsIn total, 2942 candidates were included (Impella: 214; intra-aortic balloon pump: 1326; HeartMate 3: 1402). Listing with the Impella or intra-aortic balloon pump was associated with worse postlisting survival compared with the HeartMate 3 left ventricular assist device in type O candidates (Impella: hazard ratio, 2.90 [95% CI, 1.48-5.67], P = .002; intra-aortic balloon pump: hazard ratio, 2.42 [95% CI, 1.59-3.68], P < .001) but less so in non–type O candidates. Further analysis of type O candidates demonstrated that the Impella and intra-aortic balloon pump were associated with a lower risk of postlisting mortality among those with normal height (25-75th percentile) and nonobese (body mass index <30) (Impella: hazard ratio, 1.78 [95% CI, 0.61-5.18], P = .292; intra-aortic balloon pump: hazard ratio, 1.28 [95% CI, 0.67-2.45], P = .455); among those not of normal height and nonobese, the Impella and intra-aortic balloon pump were associated with an elevated risk of postlisting mortality (Impella: hazard ratio, 3.65 [95% CI, 1.68-7.95], P = .001; intra-aortic balloon pump: hazard ratio, 3.01 [95% CI, 1.95-4.67], P < .001). ConclusionsBlood type O candidates listed with the Impella or intra-aortic balloon pump are at increased risk of postlisting mortality compared with a durable left ventricular assist device in the current organ allocation era. These effects are diminished among those with normal height and body habitus.

Impact of the colour perception of graphic design on promoting tourist destinations of Southeast Europe

Graphic design plays a crucial role in branding and marketing in the current digital era. Digital marketing impacts the promotion of tourist destinations. Tourism has become an important and growing sector that has influenced the development of a country's economy. Colour as an element of graphic design evokes emotions and sets a certain mood for an image or graphic. The purpose of this study is to determine the role of colour perception in graphic design in promoting tourist destinations of Southeast Europe (SEE). We aim to explore the relationship between graphic design and the tourism industry in SEE countries, focusing on their tourism logos and slogans for advertising their tourist destinations. The analysis of the main characteristics of logos and slogans shows that they can be effective tools for promoting and supporting tourism in countries in the SEE region. It was observed that there is compatibility between the colours used in the logo and the country flag in 64% of the tourism logos of SEE countries. The colour green is the most commonly used colour in logo design.

ASSESSING HEALTHCARE PROVIDERS’ ACCEPTANCE OF THE HOSPITAL MANAGEMENT SYSTEM IN A PRIVATE HOSPITAL IN SELANGOR, MALAYSIA

Introduction: In the current technological era, the implementation and use of information and communication technology are crucial for productivity and organizational management in the health sector. This study aimed to investigate factors influencing staff acceptance of the Hospital Management System (HMS) using the Unified Theory of Acceptance and Use of Technology (UTAUT) in a private hospital in Selangor, Malaysia. Methods: Semi-structured interviews were conducted with 25 healthcare professionals, including doctors, nurses, and administrative staff, to explore their experiences and perceptions of the HMS. Data collection was performed through interviews and observations and analyzed using thematic analysis with ATLAS.ti. Results: The study identified five key themes influencing HMS acceptance: performance expectancy, effort expectancy, social influence, facilitating conditions, and behavioral intention. Participants emphasized the importance of system reliability, speed, and user-friendly interfaces for efficient workflow. Peer support and a technology-promoting organizational culture positively influenced system use. Comprehensive training and continuous technical support were crucial for user confidence. Despite recognizing the system's benefits, participants highlighted challenges such as inadequate system integration and the need for simultaneous digital and traditional record-keeping. Conclusion: Addressing these issues and tailoring the HMS to meet specific departmental needs can enhance user satisfaction and system effectiveness. The study underscores the importance of understanding user needs and providing robust support systems to facilitate the successful implementation and adoption of HMS in healthcare settings.

Blockchain implementation for food safety in supply chain: A review.

Food safety has emerged as the topmost priority in the current fast-paced food industry era. According to the World Health Organization, around 600 million people, approximately 1 in 10 individuals worldwide, experience illness due to contaminated food consumption, resulting in nearly 0.42 million fatalities annually. The recent development in software and hardware sectors has created opportunities to improve the safety concerns in the food supply chain. The objective of this review is to explain the fundamentals of blockchain and its integration into the supply chain of various food commodities to enhance food safety. This paper presents the analysis of 31 conceptual works, 10 implementation works, 39 case studies, and other investigations in blockchain-based food supply chain from a total of 80 published papers. In this paper, the significance of adapting conceptual ideas into practical applications for effectively tracing food commodities throughout the supply chain has been discussed. This paper also describes the transformative role of blockchain platforms in the food industry, providing a decentralized and transparent ledger to access real-time and immutable records of a product's journey. In addition, both the positive impacts and challenges associated with implementing blockchain technology in the food supply chain have been evaluated. In summary, the blockchain-based food supply chains offer greater transparency, traceability, and trust, ultimately resulting in higher standards of food safety and quality.

Advanced digital competency assessment of vocational teachers': A new approach based on fuzzy-analytical hierarcy process

&lt;p&gt;Teachers need digital competence to adapt easily to the current digital era. This study tries to discover the perceptions of vocational high school (VHS) teachers in Indonesia related to advanced digital competencies, which include information, communication, content creation, digital security, and problem-solving competencies. The multi-criteria Analytical Hierarchy Process (AHP) problem-solving method is used to rank the priority digital competencies that are most mastered by the respondents, and then their performance is validated by the fuzzy AHP artificial intelligence-based method. A poll was conducted with 392 respondents, with the research instrument adopting the digital competency measurement platform from DigComp. The study's results show that the fuzzy AHP method has proven that the classical AHP method is a very good way to prioritize VHS teachers' digital skills based on several factors. The two methods gave almost identical results in determining the priority order of VHS teacher digital competencies. The survey results reveal that VHS teachers in Indonesia must immediately develop their skills in terms of digital content creation and digital security. Teachers, teacher professional organizations, and decision-makers are expected to use the findings of this study as a reference in implementing VHS teacher digital competency improvement trainings.&lt;/p&gt;

Prevalence of iron overload in patients with chronic kidney disease on peritoneal dialysis: A scoping review.

Chronic kidney disease (CKD) patients undergoing peritoneal dialysis (PD) are susceptible to complications, including iron overload, which can significantly impact their prognosis and overall health. This scoping review aimed to study the prevalence and implications of iron overload in CKD patients undergoing PD. A comprehensive search was conducted across five databases, leading to the selection of 18 papers for in-depth analysis. These studies collectively involved 381 PD patients, 60.3% were males. No consensus was reached regarding the exact diagnostic cutoff for iron overload. The investigations revealed four main aspects: (1) Seven papers identified various factors contributing to iron overload, emphasizing the role of different iron supplements and magnetic resonance imaging's capability to diagnose iron accumulation in organs; (2) Iron overload in young patients was found to hinder growth; (3) Six studies highlighted the adverse effects of iron overload, with cardiac issues being the most significant; (4) Three studies demonstrated the efficacy of iron-chelating agents, Deferoxamine and Deferasirox, in treating iron overload patients undergoing PD. Overall, the estimated prevalence of liver iron overload in CKD patients on PD ranges from approximately 10% to 28.6%, which is far lower than the prevalence of 75% elegantly shown in HD patients. While iron overload was a significant concern for CKD patients undergoing PD in the past, it is less common in the current era due to advancements in treatments, such as erythropoiesis-stimulating agents. Treatment with specific chelation agents has proven beneficial, but there is also a risk of adverse effects, necessitating meticulous monitoring and timely intervention.

Проблематика информационного шума в контексте современного кинематографа

The article is devoted to the study of the ‘information noise’ phenomenon in the context of modern cinema. As a comprehensive art form, cinema in the current era confronts this multifaceted issue. This study critically analyses the concept of information noise scrutinizing its manifestations across diverse cultural and social contexts. The author highlights various dimensions of information noise and assesses its impact on the perception and interpretation of cinematic productions, encompassing aspects like historical authenticity, value stereotyping, the preservation or substitution of core ideas, censorship influence, narrative complexity, and verbal imperfections. The article also addresses the current state of scientific development of the topic under study. It underscores people’s limitations in processing information and how perception is influenced by their socio-cultural origins. The necessity for a standardized approach to identify characteristics of information noise in film production is also emphasized.

Korelasi Filsafat dan Ilmu Pengetahuan pada Perkembangan Teknologi dan Kehidupan Peradaban Manusia Masa Kini

Rapid change technology always has impact science to change following technological developments resulting in the emergence correlation between science and philosophy to know anything or something we do not understand, know in the future. Article was written with the aim seeing science and philosophy as unity in human activities with efforts to solve problems human life to face the pattern human life era of the revolutionary movement in industry or society. Writing articles is qualitative in nature with variety literature including other journal articles in support analysis current article. Results current article show that there is a correlation between philosophy and science, including its relevance to the acceleration of technology for all societies as winners in minimizing the challenges of the current era of disruption. End current article concludes that humans are fully aware that the use of reason and reason is a solution to every problem that often occurs in line with the rapid introduction of technology into human life and daily activities in the progress of human civilization in the field of technology.

Exploring Morphometry of Endometrial Glands and Blood Vessels in Reproductive Age Women With Abnormal Uterine Bleeding.

Background Abnormal uterine bleeding (AUB) is one of the most common problems encountered in gynaecological practice. Defective endometrial angiogenesis has been implicated in various benign and malignant disorders of the endometrium. Aim This study aims to assess morphometry of endometrial glands and blood vessels in patients with AUB. Material and methods This is a one year retrospective cross sectional analysis of endometrial samples received with the diagnosis of AUB in reproductive age group. All samples were routinely processed and stained. Sections were analysed for morphometry of blood vessels and endometrial glands. Results A total of 374 cases were included. Most common histological group was proliferative followed by secretory phase. A significant difference was noted in mean vascular density, diameter, mitotic scores and height of glandular epithelium in different benign and malignant groups. Conclusion This study highlights the fact that glandular and vascular morphometry can be used to differentiate between various proliferative disorders of the endometrium. In the current era of new anti-angiogenic therapies, endometrial angiogenesis and changes in vascular morphology can be targeted, thus improving treatment modalities and patient care.

594. THE IMPACT OF PATIENT CHARACTERISTICS AND NEOADJUVANT TREATMENT ON THE TUMOUR MICRO-ENVIRONMENT OF ESOPHAGEAL CANCER

Abstract Background Esophageal cancer remains associated with poor prognosis, as even with the current standards of multimodal treatment and oncologic surgery many patients show no response to treatment, or suffer early recurrence after surgery. In the current era of precision medicine, a better understanding of the tumor microenvironment (TME) is needed to identify patients with unfavourable biology, but also to illustrate the physiopathology of host reaction to treatment. The aim of this monocentric translational study was to analyse the biomolecular characteristics of esophageal cancer in relation to key clinicopathologic parameters, and in particular to the response to neoadjuvant treatment. Methods A series of patients operated for esophageal cancer with curative intent between 01.2009 and 12.2021 were included in this study. Clinicopathological data were collected, and initial biopsies and surgical specimens were reassessed by a senior GI pathologist. The immune infiltrate markers CD3, CD8, CD163, CD68, PDL1and FOXP3 were recorded as cell counts/high power field. The CPS score was used for PD-L1 quantification, whereas the Mandard regression grade (TRG) assessed pathologic response to neoadjuvant treatment (NAT). Continuous variables were compared with the Mann-Whitney-U and ANOVA tests, and categorical ones with the Chi-2 test. Significance threshold was set at p&amp;lt;0.05. Results Overall, 68 patients (82.4% males, mean age 62.4□9.4 years, 79.4% adenocarcinoma) were included. TME in smokers had lower M2-like (CD163+, p=0.009) and total macrophages (CD68+, p=0.001), but similar CD163/68 ratio and T-cells as non-smokers. Adenocarcinoma histology compared to squamous cell, showed higher M2-like macrophages (p=0.023), mean CPS score (p=0.038) and T-cell infiltration (p=0.006). NAT increased macrophages and cytotoxic T-cells, and decreased Treg/FoxP3 cells in the TME. Chemotherapy, compared to chemoradiation, was associated with higher T-cell TME infiltration. Good responders to NAT (TRG1-2) had similar initial TME characteristics as poor responders, but they displayed lower macrophage count upon final histology (p=0.003). Conclusions In the present series, active smoking was related to attenuated, whereas adenocarcinoma histology to enhanced M2-like macrophage infiltration of esophageal cancer TME. Neoadjuvant treatment, and especially chemotherapy, recruited macrophages and T-cells in the TME. None of the biomarkers derived from the initial biopsies were associated with response to NAT, although an increased macrophage count upon final histology was related to poor response. The present study provides valuable insight to the TME composition of esophageal cancer. However, further studies are needed to assess the exact functional role of TME elements, and specifically macrophages, and their impact on clinical outcomes.