In this study, a novel large-scale barge-type floating offshore wind turbine with an aquaculture cage (LSBT-FOWT-AC) in a water depth of 100 m is designed through fully coupled analysis using the SESAM tool to support the Technical University of Denmark (DTU) 10 MW wind turbine. The intact stability and natural period of motion of the newly designed LSBT-FOWT-AC are evaluated based on the DNV rules and standards. Then, the dynamic responses of the LSBT-FOWT-AC under various sea conditions are studied. The motion of the LSBT-FOWT-AC platform is considerably affected by waves, and its motion response is within a reasonable range even under the extreme sea conditions of the 100-year return period. By analyzing the results of the out-of-plane bending moment of root of blade 1 (RootMyc1), it can be seen that the rotor frequency (1P) has a visible influence on the wind turbine. Through the analysis of dynamic response statistics of the LSBT-FOWT-AC structure by the single variable method of environmental loads, it is found that wind force exerts the greatest impact on the dynamic response compared to the wave-excitation force and current drag force.