The Eastern and Southeastern Asian regions witness the strongest land–ocean and lithosphere–asthenosphere interactions. The extreme diversity of geological features warrants a unified study for a better understanding of their geodynamic uniqueness and/or ubiquity from a regional perspective. In this paper we have explored a large coverage of potential field data and have detected high resolution Moho and Curie depths in the aforementioned regions. The oldest continental and oceanic domains, i.e. the North China craton and the Pacific and Indian Ocean have been found thermally perturbed by events probably linked to small-scale convection or serpentinization in the mantle and to numerous volcanic seamounts and ridges. The thermal perturbation has also been observed in proximity of the fossil ridge of the western Philippine Sea Basin, which shows anomalously small Curie depths. The western Pacific marginal seas have the lowest Moho temperature, with Curie depths generally larger than Moho depths. The contrary is true in most parts of easternmost Eurasian continent. Magmatic processes feeding the Permian Emeishan large igneous province could have also been genetically linked to deep mantle/crustal processes beneath the Sichuan Basin. The regionally elongated magnetic features and small Curie depths along the Triassic Yangtze-Indochina plate boundary suggest that the igneous province could be caused by tectonic processes along plate margins, rather than by a deep mantle plume. At the same time, we interpret the Caroline Ridge, the boundary between the Pacific and the Caroline Sea, as a structure having a continental origin, rather than as hotspot or arc volcanism. The surface heat flow is primarily modulated by a deep isotherm through thermal conduction. This concordance is emphasized along many subduction trenches, where zones of large Curie depths often correspond with low heat flow. Local or regional surface heat flow variations cannot be faithfully used in inferring deep thermal structures, which can be better constrained overall through Curie depths detected from surface magnetic anomalies.